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Humoral response after mRNA COVID-19 primary vaccination and single booster dose in people living with HIV compared to controls: A French nationwide multicenter cohort study—ANRS0001s COV-POPART

Loubet, Paul ; Lelievre, Jean-Daniel ; François, Alexis ; Botelho-Nevers, Elisabeth ; Chidiac, Christian ; Chirio, David ; Dubee, Vincent ; Dussol, Bertrand ; Galtier, Florence ; Hessamfar, Mojgan ; Hodaj, Enkelejda ; Jaffuel, Sylvain ; Lacombe, Karine ; Laine, Fabrice ; Lefebvre, Maeva ; Maakaroun-Vermesse, Zoha ; Makinson, Alain ; Portefaix, Aurelie ; Pourcher, Valerie ; Rey, David ; Zucman, David ; Longobardi, Julie ; Bertheau, Mathilde ; Tartour, Eric ; de Lamballerie, Xavier ; Launay, Odile ; Wittkop, Linda

International journal of infectious diseases, 2024-09, Vol.146, p.107110, Article 107110 [Peer Reviewed Journal]

Canada: Elsevier Ltd

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Title:
Humoral response after mRNA COVID-19 primary vaccination and single booster dose in people living with HIV compared to controls: A French nationwide multicenter cohort study—ANRS0001s COV-POPART
Author: Loubet, Paul ; Lelievre, Jean-Daniel ; François, Alexis ; Botelho-Nevers, Elisabeth ; Chidiac, Christian ; Chirio, David ; Dubee, Vincent ; Dussol, Bertrand ; Galtier, Florence ; Hessamfar, Mojgan ; Hodaj, Enkelejda ; Jaffuel, Sylvain ; Lacombe, Karine ; Laine, Fabrice ; Lefebvre, Maeva ; Maakaroun-Vermesse, Zoha ; Makinson, Alain ; Portefaix, Aurelie ; Pourcher, Valerie ; Rey, David ; Zucman, David ; Longobardi, Julie ; Bertheau, Mathilde ; Tartour, Eric ; de Lamballerie, Xavier ; Launay, Odile ; Wittkop, Linda
Subjects: COVID-19 ; HIV ; Immunogenicity ; Life Sciences ; Santé publique et épidémiologie ; SARS-CoV-2 ; Vaccines
Is Part Of: International journal of infectious diseases, 2024-09, Vol.146, p.107110, Article 107110
Notes: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Description: This study aimed to compare the humoral responses to mRNA COVID-19 vaccination in people living with HIV (PWH) and HIV-negative individuals. We included PWH with an undetectable viral load under ART and HIV-negative participants from the French nationwide ANRS COV-POPART cohort who had received two doses of vaccine as a primary vaccination. We compared humoral response between controls and PWH, stratified by CD4 cell count (<200/mm3 and ≥200/mm3 CD4 cell counts) at 1, 6, and 12 months after primary vaccination. A total of 1776 participants were included in this analysis, 684 PWH (99% were on ART, median CD4 counts 673 cells/mm3) and 1092 controls. At 1 month, after adjustment on age, sex, and BMI, PWH had lower seroneutralization titers than controls, and PWH with <200 CD4 cell/mm3 had lower anti-Spike SARS-CoV-2 IgG antibodies. Same results were found at 6 months. However, in participants who received a booster dose between 6 and 12 months postprimary vaccination, we did not observe differences between PWH and controls at 12 months. PWH had high responses to primary mRNA COVID-19 vaccination. In those who received a booster dose after 6 months, the humoral response at 12 months increased to similar levels to controls, even in those with low CD4 counts at baseline.
Publisher: Canada: Elsevier Ltd
Language: English

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Humoral response after mRNA COVID-19 primary vaccination and single booster dose in people living with HIV compared to controls: A French nationwide multicenter cohort study—ANRS0001s COV-POPART

Canada: Elsevier Ltd

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