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Identification of true chemical respiratory allergens: Current status, limitations and recommendations

Pemberton, Mark A. ; Arts, Josje HE ; Kimber, Ian

Regulatory toxicology and pharmacology, 2024-02, Vol.147, p.105568-105568, Article 105568 [Periódico revisado por pares]

Netherlands: Elsevier Inc

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  • Título:
    Identification of true chemical respiratory allergens: Current status, limitations and recommendations
  • Autor: Pemberton, Mark A. ; Arts, Josje HE ; Kimber, Ian
  • Assuntos: Allergens - toxicity ; Animals ; Asthma, Occupational - chemically induced ; Asthma, Occupational - diagnosis ; Chemical respiratory allergy ; Humans ; Irritants - toxicity ; Occupational asthma ; Occupational Diseases ; Occupational Exposure - adverse effects
  • É parte de: Regulatory toxicology and pharmacology, 2024-02, Vol.147, p.105568-105568, Article 105568
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: Asthma in the workplace is an important occupational health issue. It comprises various subtypes: occupational asthma (OA; both allergic asthma and irritant-induced asthma) and work-exacerbated asthma (WEA). Current regulatory paradigms for the management of OA are not fit for purpose. There is therefore an important unmet need, for the purposes of both effective human health protection and appropriate and proportionate regulation, that sub-types of work-related asthma can be accurately identified and classified, and that chemical respiratory allergens that drive allergic asthma can be differentiated according to potency. In this article presently available strategies for the diagnosis and characterisation of asthma in the workplace are described and critically evaluated. These include human health studies, clinical investigations and experimental approaches (structure-activity relationships, assessments of chemical reactivity, experimental animal studies and in vitro methods). Each of these approaches has limitations with respect to providing a clear discrimination between OA and WEA, and between allergen-induced and irritant-induced asthma. Against this background the needs for improved characterisation of work-related asthma, in the context of more appropriate regulation is discussed. •Clinical and other evidence used to identify Occupational Asthma have limitations.•Discrimination between occupational asthma and work-related asthma is necessary.•Distinguishing allergen-induced asthma from irritant-induced asthma is important.•Distinction of types of asthma is key to effective health management and regulation.
  • Editor: Netherlands: Elsevier Inc
  • Idioma: Inglês
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