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Genome-wide analysis of the world's sheep breeds reveals high levels of historic mixture and strong recent selection

Kijas, James W ; Lenstra, Johannes A ; Hayes, Ben ; Boitard, Simon ; Porto Neto, Laercio R ; San Cristobal, Magali ; Servin, Bertrand ; McCulloch, Russell ; Whan, Vicki ; Gietzen, Kimberly ; Paiva, Samuel ; Barendse, William ; Ciani, Elena ; Raadsma, Herman ; McEwan, John ; Dalrymple, Brian Tyler-Smith, Chris

PLoS biology, 2012-02, Vol.10 (2), p.e1001258-e1001258 [Revista revisada por pares]

United States: Public Library of Science

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Título:
Genome-wide analysis of the world's sheep breeds reveals high levels of historic mixture and strong recent selection
Autor: Kijas, James W ; Lenstra, Johannes A ; Hayes, Ben ; Boitard, Simon ; Porto Neto, Laercio R ; San Cristobal, Magali ; Servin, Bertrand ; McCulloch, Russell ; Whan, Vicki ; Gietzen, Kimberly ; Paiva, Samuel ; Barendse, William ; Ciani, Elena ; Raadsma, Herman ; McEwan, John ; Dalrymple, Brian
Tyler-Smith, Chris
Materias: Africa ; Animals ; Artificial insemination ; Asia ; Biology ; Body size ; Breeding ; Cattle ; Domestic animals ; Domestication ; Europe ; Gene Frequency ; Genetic diversity ; Genome ; Genomes ; Genomics ; Genotypes ; Handlers ; Haplotypes ; Horns ; Life Sciences ; Livestock ; Meat ; Milk ; Models, Genetic ; Phylogeny ; Phylogeography ; Pigmentation ; Polymorphism, Single Nucleotide ; Population ; Principal Component Analysis ; Quantitative genetics ; R&D ; Reproduction ; Research & development ; Selection, Genetic ; Sheep - genetics ; Single-nucleotide polymorphism ; Wool
Es parte de: PLoS biology, 2012-02, Vol.10 (2), p.e1001258-e1001258
Notas: ObjectType-Article-2
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Membership of the International Sheep Genomics Consortium is provided in the Acknowledgments.
The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: JWK HR JMcE BD. Performed the experiments: JWK RMcC VW KG. Analyzed the data: JWK JAL BH SB LPN MSC BS VW KG SP WB EC. Contributed reagents/materials/analysis tools: International Sheep Genomics Consortium. Wrote the paper: JWK JAL BH.
Descripción: Through their domestication and subsequent selection, sheep have been adapted to thrive in a diverse range of environments. To characterise the genetic consequence of both domestication and selection, we genotyped 49,034 SNP in 2,819 animals from a diverse collection of 74 sheep breeds. We find the majority of sheep populations contain high SNP diversity and have retained an effective population size much higher than most cattle or dog breeds, suggesting domestication occurred from a broad genetic base. Extensive haplotype sharing and generally low divergence time between breeds reveal frequent genetic exchange has occurred during the development of modern breeds. A scan of the genome for selection signals revealed 31 regions containing genes for coat pigmentation, skeletal morphology, body size, growth, and reproduction. We demonstrate the strongest selection signal has occurred in response to breeding for the absence of horns. The high density map of genetic variability provides an in-depth view of the genetic history for this important livestock species.
Editor: United States: Public Library of Science
Idioma: Inglés

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Genome-wide analysis of the world's sheep breeds reveals high levels of historic mixture and strong recent selection

United States: Public Library of Science

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