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Magnetic Resonance Imaging of Pancreatic Islets Transplanted Into the Liver in Humans

SAUDEK, František ; JIRAK, Daniel ; GIRMAN, Peter ; HERYNEK, Vit ; DEZORTOVA, Monika ; KRIZ, Jan ; PEREGRIN, Jan ; BERKOVA, Zuzana ; ZACHAROVOVA, Klára ; HAJEK, Milan

Transplantation, 2010-12, Vol.90 (12), p.1602-1606 [Revista revisada por pares]

Hagerstown, MD: Lippincott Williams & Wilkins

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Título:
Magnetic Resonance Imaging of Pancreatic Islets Transplanted Into the Liver in Humans
Autor: SAUDEK, František ; JIRAK, Daniel ; GIRMAN, Peter ; HERYNEK, Vit ; DEZORTOVA, Monika ; KRIZ, Jan ; PEREGRIN, Jan ; BERKOVA, Zuzana ; ZACHAROVOVA, Klára ; HAJEK, Milan
Materias: Biological and medical sciences ; C-Peptide - blood ; Diabetes Mellitus - surgery ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Glycated Hemoglobin A - metabolism ; Humans ; Islets of Langerhans - anatomy & histology ; Islets of Langerhans - pathology ; Islets of Langerhans Transplantation - methods ; Liver - anatomy & histology ; Magnetic Resonance Imaging - methods ; Medical sciences ; Phantoms, Imaging ; Portal Vein - anatomy & histology ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tissue, organ and graft immunology
Es parte de: Transplantation, 2010-12, Vol.90 (12), p.1602-1606
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Descripción: In vitro labeling of pancreatic islets by iron nanoparticles enables their detection as hypoitnense spots on serial magnetic resonance (MR) images. We report the first results of a pilot trial aiming to test the feasibility and safety of this technique in humans. Islets were labeled in culture with 5 μL/mL ferucarbotran for 6 to 48 hr and transplanted into the portal vein (12 infusions) in 8 C-peptide negative recipients. The liver area was examined the next day and 1, 4, and 24 weeks posttransplant using a 3T MR scanner. In all recipients, significant C-peptide levels and near-normal HbA1c values were achieved with 50% to 80% insulin dose reduction. No side effects related to the labeling procedure were documented. Typically, a significant islet spot number decrease (on average 60%) was detected at week 1 with subsequent only slight decrease for up to 24 weeks. In two subjects with labeling period of less than 6 and 10 hr, only few islet spots were detected corresponding to poor islet visualization in phantoms labeled for the same period of time. Pancreatic islets (PI) visualization was safe and successful in all recipients but was less efficient if labeling period was less than 16 hr. Significant decrease of islet spots occurred at week 1, suggesting early islet destruction or impaired engraftment. Afterward, the islet spot numbers remained stable for up to 24 weeks. Data show that MR detection of ferucarbotran-labeled islets enables their long-term noninvasive visualization and correlates with sustained C-peptide production.
Editor: Hagerstown, MD: Lippincott Williams & Wilkins
Idioma: Inglés

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Magnetic Resonance Imaging of Pancreatic Islets Transplanted Into the Liver in Humans

SAUDEK, František ; JIRAK, Daniel ; GIRMAN, Peter ; HERYNEK, Vit ; DEZORTOVA, Monika ; KRIZ, Jan ; PEREGRIN, Jan ; BERKOVA, Zuzana ; ZACHAROVOVA, Klára ; HAJEK, Milan

Hagerstown, MD: Lippincott Williams & Wilkins

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