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Enteric bacteria promote human and mouse norovirus infection of B cells

Jones, Melissa K. ; Watanabe, Makiko ; Zhu, Shu ; Graves, Christina L. ; Keyes, Lisa R. ; Grau, Katrina R. ; Gonzalez-Hernandez, Mariam B. ; Iovine, Nicole M. ; E. Wobus, Christiane ; Vinjé, Jan ; Tibbetts, Scott A. ; M. Wallet, Shannon ; Karst, Stephanie M.

Science (American Association for the Advancement of Science), 2014-11, Vol.346 (6210), p.755-759 [Periódico revisado por pares]

United States: American Association for the Advancement of Science

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Título:
Enteric bacteria promote human and mouse norovirus infection of B cells
Autor: Jones, Melissa K. ; Watanabe, Makiko ; Zhu, Shu ; Graves, Christina L. ; Keyes, Lisa R. ; Grau, Katrina R. ; Gonzalez-Hernandez, Mariam B. ; Iovine, Nicole M. ; E. Wobus, Christiane ; Vinjé, Jan ; Tibbetts, Scott A. ; M. Wallet, Shannon ; Karst, Stephanie M.
Assuntos: Animals ; Anti-Bacterial Agents - pharmacology ; Antibiotics ; Antigens ; B-Lymphocytes - immunology ; B-Lymphocytes - virology ; Bacteria ; Caliciviridae Infections - immunology ; Caliciviridae Infections - microbiology ; Caliciviridae Infections - virology ; Cell Line ; Cellular ; Depletion ; Enterobacteriaceae - drug effects ; Enterobacteriaceae - physiology ; Gastroenteritis - immunology ; Gastroenteritis - microbiology ; Gastroenteritis - virology ; Genome, Viral - genetics ; Genome, Viral - physiology ; Homeodomain Proteins - genetics ; Humans ; In vitro testing ; Intestines - immunology ; Intestines - microbiology ; Lymphocytes ; Mice ; Mice, Mutant Strains ; Norovirus ; Norovirus - physiology ; Peyer's Patches - immunology ; Peyer's Patches - virology ; Tropism ; Viral infections ; Virus Replication
É parte de: Science (American Association for the Advancement of Science), 2014-11, Vol.346 (6210), p.755-759
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SourceType-Scholarly Journals-1
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content type line 23
These authors contributed equally to this work.
Descrição: The cell tropism of human noroviruses and the development of an in vitro infection model remain elusive. Although susceptibility to individual human norovirus strains correlates with an individual’s histo-blood group antigen (HBGA) profile, the biological basis of this restriction is unknown. We demonstrate that human and mouse noroviruses infected B cells in vitro and likely in vivo. Human norovirus infection of B cells required the presence of HBGA-expressing enteric bacteria. Furthermore, mouse norovirus replication was reduced in vivo when the intestinal microbiota was depleted by means of oral antibiotic administration. Thus, we have identified B cells as a cellular target of noroviruses and enteric bacteria as a stimulatory factor for norovirus infection, leading to the development of an in vitro infection model for human noroviruses.
Editor: United States: American Association for the Advancement of Science
Idioma: Inglês

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Enteric bacteria promote human and mouse norovirus infection of B cells

Jones, Melissa K. ; Watanabe, Makiko ; Zhu, Shu ; Graves, Christina L. ; Keyes, Lisa R. ; Grau, Katrina R. ; Gonzalez-Hernandez, Mariam B. ; Iovine, Nicole M. ; E. Wobus, Christiane ; Vinjé, Jan ; Tibbetts, Scott A. ; M. Wallet, Shannon ; Karst, Stephanie M.

United States: American Association for the Advancement of Science

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