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Sex-Dependent Effects of the APOE ɛ4 Allele on Behavioral Traits and White Matter Structures in Young Adults

Takeuchi, Hikaru ; Tomita, Hiroaki ; Browne, Ryan ; Taki, Yasuyuki ; Kikuchi, Yoshie ; Ono, Chiaki ; Yu, Zhiqian ; Nouchi, Rui ; Yokoyama, Ryoichi ; Kotozaki, Yuka ; Nakagawa, Seishu ; Sekiguchi, Atsushi ; Iizuka, Kunio ; Hanawa, Sugiko ; Araki, Tsuyoshi ; Miyauchi, Carlos Makoto ; Sakaki, Kohei ; Nozawa, Takayuki ; Ikeda, Shigeyuki ; Yokota, Susumu ; Magistro, Daniele ; Sassa, Yuko ; Kawashima, Ryuta

Cerebral cortex (New York, N.Y. 1991), 2021-01, Vol.31 (1), p.672-680 [Peer Reviewed Journal]

United States: Oxford University Press

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Title:
Sex-Dependent Effects of the APOE ɛ4 Allele on Behavioral Traits and White Matter Structures in Young Adults
Author: Takeuchi, Hikaru ; Tomita, Hiroaki ; Browne, Ryan ; Taki, Yasuyuki ; Kikuchi, Yoshie ; Ono, Chiaki ; Yu, Zhiqian ; Nouchi, Rui ; Yokoyama, Ryoichi ; Kotozaki, Yuka ; Nakagawa, Seishu ; Sekiguchi, Atsushi ; Iizuka, Kunio ; Hanawa, Sugiko ; Araki, Tsuyoshi ; Miyauchi, Carlos Makoto ; Sakaki, Kohei ; Nozawa, Takayuki ; Ikeda, Shigeyuki ; Yokota, Susumu ; Magistro, Daniele ; Sassa, Yuko ; Kawashima, Ryuta
Subjects: Adolescent ; Adult ; Alzheimer Disease - genetics ; Alzheimer Disease - metabolism ; Apolipoprotein E4 - genetics ; Apolipoprotein E4 - metabolism ; Apolipoproteins E ; Behavior - physiology ; Cognition - physiology ; Female ; Genotype ; Humans ; Male ; Neuropsychological Tests ; Original ; Sex Factors ; White Matter - metabolism ; White Matter - pathology ; Young Adult
Is Part Of: Cerebral cortex (New York, N.Y. 1991), 2021-01, Vol.31 (1), p.672-680
Notes: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Description: Abstract The APOE ɛ4 allele is associated with a risk of Alzheimer’s disease in the elderly, with the association being pronounced in females. Conversely, findings of the effects of the APOE ɛ4 allele in young adults are mixed. Here, we investigated the sex–genotype interaction effects of the APOE ɛ4 allele on cognitive functions as well as brain structures among 1258 young adults. After adjusting for multiple comparisons, there were significant effects of the interaction between sex and the number of APOE ɛ4 allele on some speed tasks (e.g., simple processing speed tasks and the reverse Stroop task) as well as on regional white matter volume (rWMV). The observed sex–genotype interaction conferred better cognitive performance and greater rWMV in the anterior frontal and precentral white matter areas in females having more APOE ɛ4 alleles and reduced rWMV in the same areas in male having more APOE ɛ4 alleles. These findings support the long-debated antagonistic pleiotropic effects of the APOE ɛ4 allele in females.
Publisher: United States: Oxford University Press
Language: English

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Sex-Dependent Effects of the APOE ɛ4 Allele on Behavioral Traits and White Matter Structures in Young Adults

United States: Oxford University Press

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