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Heavy metals and metalloids as a cause for protein misfolding and aggregation

Tamás, Markus J ; Sharma, Sandeep K ; Ibstedt, Sebastian ; Jacobson, Therese ; Christen, Philipp

Biomolecules, 2014-02, Vol.4 (1), p.252-267 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Heavy metals and metalloids as a cause for protein misfolding and aggregation
Autor: Tamás, Markus J ; Sharma, Sandeep K ; Ibstedt, Sebastian ; Jacobson, Therese ; Christen, Philipp
Assuntos: Animals ; Biochemistry and Molecular Biology ; Biokemi och molekylärbiologi ; chaperone ; Farmakologi och toxikologi ; Humans ; metal toxicity ; metalloid toxicity ; Metalloids - pharmacology ; Metalloids - toxicity ; Metals, Heavy - pharmacology ; Metals, Heavy - toxicity ; Microbiology ; Mikrobiologi ; Pharmacology and Toxicology ; protein ; Protein Aggregates - drug effects ; protein aggregation ; protein degradation ; protein folding ; Protein Folding - drug effects ; Proteins - chemistry ; Proteins - metabolism ; Review ; yeast
É parte de: Biomolecules, 2014-02, Vol.4 (1), p.252-267
Descrição: While the toxicity of metals and metalloids, like arsenic, cadmium, mercury, lead and chromium, is undisputed, the underlying molecular mechanisms are not entirely clear. General consensus holds that proteins are the prime targets; heavy metals interfere with the physiological activity of specific, particularly susceptible proteins, either by forming a complex with functional side chain groups or by displacing essential metal ions in metalloproteins. Recent studies have revealed an additional mode of metal action targeted at proteins in a non-native state; certain heavy metals and metalloids have been found to inhibit the in vitro refolding of chemically denatured proteins, to interfere with protein folding in vivo and to cause aggregation of nascent proteins in living cells. Apparently, unfolded proteins with motile backbone and side chains are considerably more prone to engage in stable, pluridentate metal complexes than native proteins with their well-defined 3D structure. By interfering with the folding process, heavy metal ions and metalloids profoundly affect protein homeostasis and cell viability. This review describes how heavy metals impede protein folding and promote protein aggregation, how cells regulate quality control systems to protect themselves from metal toxicity and how metals might contribute to protein misfolding disorders.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Heavy metals and metalloids as a cause for protein misfolding and aggregation

Tamás, Markus J ; Sharma, Sandeep K ; Ibstedt, Sebastian ; Jacobson, Therese ; Christen, Philipp

Switzerland: MDPI AG

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