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Prevalence and clinical consequences of Hepatitis C virus infection in patients undergoing hematopoietic stem cell transplantation

Diaz, Ana Claudia Marques Barbosa ; Witkin, Steven Sol ; Almeida Neto, Cesar de ; Mendrone Junior, Alfredo ; Rocha, Vanderson ; Costa, Silvia Figueiredo ; Ramos, Jessica Fernandes ; Mendes-Correa, Maria Cassia

Revista do Instituto de Medicina Tropical de São Paulo, 2024-01, Vol.66, p.e11-8 [Revista revisada por pares]

Brazil: Instituto de Medicina Tropical de Sao Paulo

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Título:
Prevalence and clinical consequences of Hepatitis C virus infection in patients undergoing hematopoietic stem cell transplantation
Autor: Diaz, Ana Claudia Marques Barbosa ; Witkin, Steven Sol ; Almeida Neto, Cesar de ; Mendrone Junior, Alfredo ; Rocha, Vanderson ; Costa, Silvia Figueiredo ; Ramos, Jessica Fernandes ; Mendes-Correa, Maria Cassia
Materias: Adult ; Antiviral Agents - therapeutic use ; Ascites ; Brazil - epidemiology ; Chagas disease ; Genotype & phenotype ; Hematopoietic Stem Cell Transplantation - adverse effects ; Hepacivirus - genetics ; Hepatitis B ; Hepatitis C ; Hepatitis C - complications ; Hepatitis C - epidemiology ; Hepatitis C, Chronic - drug therapy ; HIV ; Hospitals ; Human immunodeficiency virus ; Humans ; Infections ; Liver cirrhosis ; Liver Cirrhosis - epidemiology ; Medical records ; Original ; Prevalence ; Retrospective Studies ; Stem cell transplantation ; Syphilis ; TROPICAL MEDICINE ; Viruses
Es parte de: Revista do Instituto de Medicina Tropical de São Paulo, 2024-01, Vol.66, p.e11-8
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
The authors declare that they have no known conflict of financial interests.
CONFLICT OF INTERESTS
Descripción: Hepatitis C virus (HCV) infection is a significant cause of morbidity and mortality among hematopoietic stem cell transplant (HCT) recipients. In Brazil, its occurrence in HCT recipients remains undetermined. We now report on HCV prevalence in HCT recipients and its clinical consequences. The medical records of all HCT recipients seen at Hospital das Clinicas, Sao Paulo University Medical School, from January 2010 to January 2020 were reviewed to determine HCV serostatus. A retrospective analysis of medical charts was undertaken on all seropositive cases to determine HCV genotype, presence of liver fibrosis, co-infections with other viruses, previous treatments, and clinical evolution of liver pathology after HCT. Of the 1,293 HCT recipients included in the study, seven (0.54%) were HCV antibody-positive and five (0.39%) were also viremic for HCV-RNA. Four of these individuals had moderate to severe liver fibrosis (METAVIR F2/F3) and one was cirrhotic. Two of the viremic patients developed acute liver dysfunction following transplantation. All patients had their acute episode of liver dysfunction resolved with no further complications. Four of the viremic patients were treated for HCV infection with direct acting agents (DAA). Information regarding HCV treatment was lacking for one of the viremic HCV patients due to loss of follow up. Sustained anti-virologic responses were observed in three cases after the use of DAA. The detection of HCV in hematological adults undergoing HCT and its successful treatment with DAA highlight the necessity of testing for HCV both prior to and following transplantation.
Editor: Brazil: Instituto de Medicina Tropical de Sao Paulo
Idioma: Inglés;Portugués

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Prevalence and clinical consequences of Hepatitis C virus infection in patients undergoing hematopoietic stem cell transplantation

Diaz, Ana Claudia Marques Barbosa ; Witkin, Steven Sol ; Almeida Neto, Cesar de ; Mendrone Junior, Alfredo ; Rocha, Vanderson ; Costa, Silvia Figueiredo ; Ramos, Jessica Fernandes ; Mendes-Correa, Maria Cassia

Brazil: Instituto de Medicina Tropical de Sao Paulo

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