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Domestic use of pesticides during early periods of development and risk of testicular germ cell tumors in adulthood: a French nationwide case-control study

Danjou, Aurélie M N ; Pérol, Olivia ; Coste, Astrid ; Faure, Elodie ; Béranger, Rémi ; Boyle, Helen ; Belladame, Elodie ; Grassot, Lény ; Dubuis, Matthieu ; Spinosi, Johan ; Bouaoun, Liacine ; Fléchon, Aude ; Bujan, Louis ; Drouineaud, Véronique ; Eustache, Florence ; Berthaut, Isabelle ; Perrin, Jeanne ; Brugnon, Florence ; Charbotel, Barbara ; Schüz, Joachim ; Fervers, Béatrice

Environmental health, 2021-10, Vol.20 (1), p.111-18, Article 111 [Periódico revisado por pares]

England: BioMed Central Ltd

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Título:
Domestic use of pesticides during early periods of development and risk of testicular germ cell tumors in adulthood: a French nationwide case-control study
Autor: Danjou, Aurélie M N ; Pérol, Olivia ; Coste, Astrid ; Faure, Elodie ; Béranger, Rémi ; Boyle, Helen ; Belladame, Elodie ; Grassot, Lény ; Dubuis, Matthieu ; Spinosi, Johan ; Bouaoun, Liacine ; Fléchon, Aude ; Bujan, Louis ; Drouineaud, Véronique ; Eustache, Florence ; Berthaut, Isabelle ; Perrin, Jeanne ; Brugnon, Florence ; Charbotel, Barbara ; Schüz, Joachim ; Fervers, Béatrice
Assuntos: Adult ; Animals ; Birth ; Case-Control Studies ; Case-control study ; Cats ; Chemical pest control ; Child development ; Confidence intervals ; Cryptorchidism ; Developed countries ; Dogs ; Domestic use ; Environment ; Environmental aspects ; Environmental health ; Epidemiology ; Female ; Fungicides ; Gardening ; Germ cell tumors ; Health aspects ; Herbicides ; Humans ; Insecticides ; Life Sciences ; Male ; Mothers ; Neoplasms, Germ Cell and Embryonal - chemically induced ; Neoplasms, Germ Cell and Embryonal - epidemiology ; Pathology ; Pest control ; Pesticides ; Pets ; Pregnancy ; Puberty ; Questionnaires ; Risk ; Risk Factors ; Seminoma ; Sperm donations ; Statistical analysis ; Testes ; Testicular cancer ; Testicular germ cell tumor ; Testicular Neoplasms ; Tumors ; Young men
É parte de: Environmental health, 2021-10, Vol.20 (1), p.111-18, Article 111
Notas: PMCID: PMC8554827
Descrição: Testicular germ cell tumours (TGCT) are the most frequent cancers in young men in developed countries and their incidence rate has doubled worldwide over the past 40 years. Early life exposures to pesticides are suspected to increase TGCT risk. Our research aimed at estimating adult TGCT risk associated with parental domestic use of pesticides during early periods of child development. We conducted a case-control study of 304 TGCT cases, aged 18-45 years old, recruited in 20 French university hospitals, and 274 controls frequency-matched on hospital and birth year. Participants' mothers provided information on their domestic use of pesticides from 1 year before start of pregnancy to 1 year after their son's birth, for gardening activities, treatment of indoor plants, pets, wood and mold, and pest control. Odds ratios (OR) for TGCT (overall and by histological subtype) and 95% confidence intervals (CI) were estimated using conditional logistic regression. Prevalence of reported domestic use of pesticides was 77.3% for insecticides, 15.9% for fungicides and 12.1% for herbicides. While no association was found for any use of insecticides (OR = 1.27, CI = 0.80-2.01) or herbicides (OR = 1.15, CI = 0.67-2.00), elevated risks of TGCT overall (OR = 1.73, CI = 1.04-2.87) and non-seminoma subtype (OR = 2.44, CI = 1.26-4.74) were observed for any use of fungicides. When specific purposes were examined, using fungicides and/or insecticides for woodwork (OR = 2.35, CI = 1.06-5.20) and using insecticides on cats and dogs (OR = 1.95, CI = 1.12-3.40) were associated with increased risk of non-seminoma subtype. We found no association for seminoma subtype. Although recall bias may partially explain the elevated ORs, our study provides some evidence of a positive association between domestic use of pesticides during early periods of development, particularly fungicides and risk of adult TGCT and non-seminoma. Given the common domestic use of pesticides in France, further research on TGCT risk is warranted.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Domestic use of pesticides during early periods of development and risk of testicular germ cell tumors in adulthood: a French nationwide case-control study

England: BioMed Central Ltd

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