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A genome-wide scan for genes under balancing selection in the plant pathogen Ralstonia solanacearum

Castillo, José A ; Agathos, Spiros N

BMC ecology and evolution, 2019-06, Vol.19 (1), p.123-123, Article 123 [Periódico revisado por pares]

England: BioMed Central Ltd

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A genome-wide scan for genes under balancing selection in the plant pathogen Ralstonia solanacearum
Autor: Castillo, José A ; Agathos, Spiros N
Assuntos: Alleles ; Bacteria ; Balancing ; Balancing selection ; Biodiversity ; Bioinformatics ; Biological Evolution ; Blood diseases ; Burkholderia ; Chromosomes ; Defense industry ; Defense mechanisms ; Demographics ; Deoxyribonucleic acid ; Disease ; Dismantling ; DNA ; Evolutionary genetics ; Extreme values ; Fitness ; Fu & Li’s D ; Gene pool ; Genes ; Genetic aspects ; Genetic diversity ; Genetics ; Genome, Bacterial ; Genome-wide association studies ; Genomes ; Genomics ; Host plants ; Host range ; Host Specificity ; Immune response ; Metabolism ; Mutation ; Pathogenic microorganisms ; Pathogens ; Phylogenetics ; Plant bacterial diseases ; Plant Diseases - microbiology ; Plant immunity ; Plant resistance ; Plants ; Polymorphism ; Population ; Population genetics ; Population statistics ; Populations ; Prospective Studies ; Ralstonia solanacearum ; Ralstonia solanacearum - cytology ; Ralstonia solanacearum - genetics ; Ralstonia solanacearum - pathogenicity ; Reproductive fitness ; Species ; Statistical analysis ; Tajima’s D ; Virulence ; Virulence (Microbiology) ; Virulence related genes ; Watterson’s theta ; Wilt
É parte de: BMC ecology and evolution, 2019-06, Vol.19 (1), p.123-123, Article 123
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Descrição: Plant pathogens are under significant selective pressure by the plant host. Consequently, they are expected to have adapted to this condition or contribute to evading plant defenses. In order to acquire long-term fitness, plant bacterial pathogens are usually forced to maintain advantageous genetic diversity in populations. This strategy ensures that different alleles in the pathogen's gene pool are maintained in a population at frequencies larger than expected under neutral evolution. This selective process, known as balancing selection, is the subject of this work in the context of a common bacterial phytopathogen. We performed a genome-wide scan of Ralstonia solanacearum species complex, an aggressive plant bacterial pathogen that shows broad host range and causes a devastating disease called 'bacterial wilt'. Using a sliding window approach, we analyzed 57 genomes from three phylotypes of the R. solanacearum species complex to detect signatures of balancing selection. A total of 161 windows showed extreme values in three summary statistics of population genetics: Tajima's D, θ and Fu & Li's D*. We discarded any confounding effects due to demographic events by means of coalescent simulations of genetic data. The prospective windows correspond to 78 genes with known function that map in any of the two main replicons (1.7% of total number of genes). The candidate genes under balancing selection are related to primary metabolism and other basal activities (51.3%) or directly associated to virulence (48.7%), the latter being involved in key functions targeted to dismantle plant defenses or to participate in critical stages in the pathogenic process. We identified various genes under balancing selection that play a significant role in basic metabolism as well as in virulence of the R. solanacearum species complex. These genes are useful to understand and monitor the evolution of bacterial pathogen populations and emerge as potential candidates for future treatments to induce specific plant immune responses.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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A genome-wide scan for genes under balancing selection in the plant pathogen Ralstonia solanacearum

Castillo, José A ; Agathos, Spiros N

England: BioMed Central Ltd

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