Effect of Incorporation of Antifungal Agents on the Ultimate Tensile Strength of Temporary Soft Denture Liners

• Autor: Neppelenbroek, Karin Hermana ; Lima, Jozely Francisca Mello ; Hotta, Juliana ; Galitesi, Lucas Lulo ; Almeida, Ana Lucia Pompéia Fraga ; Urban, Vanessa Migliorini
• Assuntos: Antifungal agents ; Anti‐infective agents ; Biofilms ; Candida albicans ; Chlorhexidine ; Dentistry ; denture liners ; denture stomatitis ; Elongation ; Itraconazole ; Ketoconazole ; Miconazole ; Nystatin ; Powder ; Tensile strength
• É parte de: Journal of prosthodontics, 2018-02, Vol.27 (2), p.177-181
• Notas: Part of this manuscript was presented as a poster at the Sixth International Association for Dental Research Pan‐European Region Meeting (IADR/PER), 2012, Helsinki, Finland
  The authors report no conflicts of interest
  This study was supported by the São Paulo Research Foundation‐FAPESP (grants 2010/07932‐8; 2010/19636‐4; 2011/06479‐0) and National Council for the Improvement of Higher Education‐CAPES
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• Descrição: Purpose To investigate the ultimate tensile strength of temporary soft denture liners modified by minimum inhibitory concentrations (MICs) of antifungal agents for Candida albicans biofilm (SC5314) determined in previous microbiological research. Materials and Methods Dumbbell‐shaped specimens (n = 7) with a central cross‐sectional area of 6 × 3 × 33 mm were produced by Softone and Trusoft, without (control) or with incorporation of drugs in powder form at MICs for C. albicans biofilm (per g of material powder): nystatin (0.032 g), chlorhexidine diacetate (0.064 g), ketoconazole (0.128 g), miconazole (0.256 g), and itraconazole (0.256 g). After plasticization, specimens were immersed in distilled water at 37°C for 24 hours, 7 or 14 days, and then tested in tension in a universal testing machine at 40 mm/min. Data of tensile strength (MPa) and elongation percentage (%) were submitted to 3‐way ANOVA and Tukey's test (α = 0.05). Results At the end of 14 days, the tensile strength for both materials was significantly lower in the groups modified by miconazole and itraconazole compared to the other groups (p < 0.0001), which showed no significant difference between them (p > 0.05). After 7 and 14 days in water, miconazole and itraconazole added into both materials resulted in significantly lower elongation percentages compared to the other antifungal agents and control (p < 0.0001), which were similar to each other (p > 0.05). Conclusions The addition of the nystatin, chlorhexidine, and ketoconazole at MICs for C. albicans biofilm resulted in no harmful effects on the tensile strength and elongation percentage of the temporary soft denture liner materials up to 14 days.
  
• Editor: United States: Wiley Subscription Services, Inc
  
• Idioma: Inglês