Diagnostic Neurophysiologic Biomarkers for Task‐Specific Dystonia

• Autor: Merchant, Shabbir Hussain I. ; Wu, Tianxia ; Hallett, Mark
• Assuntos: Biomarkers ; Brief Report ; Brief Reports ; cortical silent period ; diagnostic biomarkers ; Dystonia ; task‐specific dystonia ; transcranial magnetic stimulation
• É parte de: Movement disorders clinical practice (Hoboken, N.J.), 2022-05, Vol.9 (4), p.468-472
• Notas: Relevant disclosures and conflicts of interest are listed at the end of this article.
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• Descrição: ABSTRACT Background Task‐specific dystonia (TSD) is a challenging clinical diagnosis with no objective diagnostic biomarkers. Objective The objective of this study was to test 2 neurophysiologic variables using transcranial magnetic stimulation as potential diagnostic biomarkers for TSD. Methods We tested (1) cortical silent period (CSP) and (2) dorsal inferior parietal lobule‐motor cortex (dIPL‐M1) physiologic connectivity in 9 patients with the writer's cramp form of TSD and 12 healthy volunteers on 2 separate sessions. Results CSP was significantly prolonged (P < 0.0001) in TSD and could classify TSD with high sensitivity and specificity with areas under the receiver operating characteristic curve (AUCs) = 0.94 and 0.90, respectively, for 2 separate sessions with an intraclass correlation = 0.79. dIPL‐M1 interaction was notable for significant motor cortical inhibition in TSD compared with facilitation in healthy subjects (P < 0.0001) and could classify TSD with high sensitivity and specificity with AUCs = 0.96 and 0.86, respectively. Conclusion CSP and dIPL‐M1 physiologic connectivity can classify TSD with high sensitivity, specificity, reproducibility, and reliability.
  
• Editor: Hoboken, USA: John Wiley & Sons, Inc
  
• Idioma: Inglês