Ethnicity and socio-economic status affects the incidence and survival of hepatosplenic T-cell lymphoma
ABCD PBi
Ethnicity and socio-economic status affects the incidence and survival of hepatosplenic T-cell lymphoma
Autor:
Bishton, Mark J
;
Crooks, Colin J
;
Card, Timothy R
;
West, Joe
Assuntos:
Allografts
;
Cancer therapies
;
Cell survival
;
Comorbidity
;
Epidemiology
;
Ethnicity
;
Lymphoma
;
Minority & ethnic groups
;
Population studies
;
Stem cell transplantation
;
T-cell lymphoma
É parte de:
British journal of haematology, 2024-06, Vol.204 (6), p.2222-2226
Notas:
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição:
To address the lack of contemporary population-based epidemiological studies of hepatosplenic T-cell lymphoma (HSTCL), we undertook a population-based study of ICD-O-3-coded HSTCL in England. We used the National Cancer Registration Dataset and linked datasets on hospital admissions, Systemic Anti-Cancer Therapy, socio-demographics, comorbidities and death, identifying cases from 1 January 2013 to 31 December 2019 with survival data up to 5 January 2021. Crude and directly age-standardised incidence rates per million persons per year were calculated. Crude and adjusted incidence rate ratios compared incidence between groups using Poisson regression. A Cox proportional hazards model estimated mortality risks adjusted for age, sex, ethnicity, deprivation and allogenic stem cell transplant (allo-SCT; time varying). We identified 44 patients, mean age 42 years. Median survival was 11 months, and 1 and 5 year survivals were 48% (95% CI 29%-43%) and 22% (95% CI 12%-42%) respectively. The age-standardised incidence was 0.1 per million/year. Incidence was higher in areas with greater deprivation (0.15 per million/year), and more cases than expected were in non-White patients (39%). Non-Whites had a twofold increased risk of death (adjusted hazard ratio 2.21 [95% CI 1.03-4.78]) even after adjusting for deprivation, younger age and allo-SCT. In conclusion, ethnicity and socio-economic status affect both the incidence and survival of HSTCL.
Editor:
England: Blackwell Publishing Ltd
Idioma:
Inglês