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The effect of guideline-consistent antiemetic therapy on chemotherapy-induced nausea and vomiting (CINV): the Pan European Emesis Registry (PEER)

Aapro, M. ; Molassiotis, A. ; Dicato, M. ; Peláez, I. ; Rodríguez-Lescure, Á. ; Pastorelli, D. ; Ma, L. ; Burke, T. ; Gu, A. ; Gascon, P. ; Roila, F.

Annals of oncology, 2012-08, Vol.23 (8), p.1986-1992 [Peer Reviewed Journal]

Oxford: Elsevier Ltd

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Title:
The effect of guideline-consistent antiemetic therapy on chemotherapy-induced nausea and vomiting (CINV): the Pan European Emesis Registry (PEER)
Author: Aapro, M. ; Molassiotis, A. ; Dicato, M. ; Peláez, I. ; Rodríguez-Lescure, Á. ; Pastorelli, D. ; Ma, L. ; Burke, T. ; Gu, A. ; Gascon, P. ; Roila, F.
Subjects: antiemetic therapy ; Antiemetics - therapeutic use ; Antineoplastic agents ; Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - adverse effects ; Biological and medical sciences ; chemotherapy ; emesis ; Female ; Guideline Adherence ; guidelines ; Humans ; Male ; Medical sciences ; Middle Aged ; nausea ; Nausea - chemically induced ; Nausea - drug therapy ; Nausea - prevention & control ; Nausea - therapy ; Pharmacology. Drug treatments ; Practice Guidelines as Topic ; Prospective Studies ; Vomiting - chemically induced ; Vomiting - drug therapy ; Vomiting - prevention & control ; Vomiting - therapy
Is Part Of: Annals of oncology, 2012-08, Vol.23 (8), p.1986-1992
Description: While guidelines for preventing chemotherapy-induced nausea and vomiting (CINV) are widely available, clinical uptake of guidelines remains low. Our objective was to evaluate the effect of guideline-consistent CINV prophylaxis (GCCP) on patient outcomes. This prospective, observational multicenter study enrolled chemotherapy-naive adults initiating single-day highly or moderately emetogenic chemotherapy (HEC or MEC) for cancer. Patients completed 6-day daily diaries beginning with cycle 1 for up to three chemotherapy cycles. The primary study end point, complete response (no emesis and no use of rescue therapy) during 120 h after cycle 1 chemotherapy, was compared between GCCP and guideline-inconsistent CINV prophylaxis (GICP) cohorts using multivariate logistic regression, adjusting for potential confounding factors. In cycle 1 (N = 991), use of GCCP was 55 % and 46 % during acute and delayed phases, respectively, and 29 % for the overall study period (acute plus delayed phases). Complete response was recorded by 172/287 (59.9 % ) and 357/704 (50.7 % ) patients in GCCP and GICP cohorts, respectively (P = 0.008). The adjusted odds ratio for complete response was 1.43 (95 % confidence interval 1.04–1.97; P = 0.027) for patients receiving GCCP versus GICP. GCCP reduces the incidence of CINV after single-day HEC and MEC.
Publisher: Oxford: Elsevier Ltd
Language: English

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The effect of guideline-consistent antiemetic therapy on chemotherapy-induced nausea and vomiting (CINV): the Pan European Emesis Registry (PEER)

Aapro, M. ; Molassiotis, A. ; Dicato, M. ; Peláez, I. ; Rodríguez-Lescure, Á. ; Pastorelli, D. ; Ma, L. ; Burke, T. ; Gu, A. ; Gascon, P. ; Roila, F.

Oxford: Elsevier Ltd

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