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Broadly Neutralizing Antibodies Present New Prospects to Counter Highly Antigenically Diverse Viruses

Burton, Dennis R. ; Poignard, Pascal ; Stanfield, Robyn L. ; Wilson, Ian A.

Science (American Association for the Advancement of Science), 2012-07, Vol.337 (6091), p.183-186 [Peer Reviewed Journal]

United States: American Association for the Advancement of Science

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Title:
Broadly Neutralizing Antibodies Present New Prospects to Counter Highly Antigenically Diverse Viruses
Author: Burton, Dennis R. ; Poignard, Pascal ; Stanfield, Robyn L. ; Wilson, Ian A.
Subjects: AIDS Vaccines - immunology ; Animals ; Antibodies ; Antibodies, Neutralizing - immunology ; Antibodies, Viral - immunology ; Antigenic Variation ; Antigens ; Drug Discovery ; env Gene Products, Human Immunodeficiency Virus - chemistry ; env Gene Products, Human Immunodeficiency Virus - immunology ; Epitopes ; Hepacivirus - immunology ; Hepatitis C - immunology ; Hepatitis C - prevention & control ; Hepatitis C virus ; HIV ; HIV Antibodies - chemistry ; HIV Antibodies - immunology ; HIV Infections - immunology ; HIV Infections - prevention & control ; HIV-1 - immunology ; HIV-1 - pathogenicity ; Human behavior ; Human immunodeficiency virus ; Humans ; Immune systems ; Influenza ; Influenza Vaccines ; Influenza, Human - immunology ; Influenza, Human - prevention & control ; Models, Molecular ; Neutralizing ; Orthomyxoviridae ; Orthomyxoviridae - immunology ; Pathogens ; Polysaccharides ; Receptors ; REVIEW ; Vaccination ; Vaccines ; Viruses
Is Part Of: Science (American Association for the Advancement of Science), 2012-07, Vol.337 (6091), p.183-186
Notes: ObjectType-Article-2
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Description: Certain human pathogens avoid elimination by our immune system by rapidly mutating the surface protein sites targeted by antibody responses, and consequently they tend to be problematic for vaccine development. The behavior described is prominent for a subset of viruses—the highly antigenically diverse viruses—which include HIV, influenza, and hepatitis C viruses. However, these viruses do harbor highly conserved exposed sites, usually associated with function, which can be targeted by broadly neutralizing antibodies. Until recently, not many such antibodies were known, but advances in the field have enabled increasing numbers to be identified. Molecular characterizations of the antibodies and, most importantly, of the sites of vulnerability that they recognize give hope for the discovery of new vaccines and drugs.
Publisher: United States: American Association for the Advancement of Science
Language: English

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Broadly Neutralizing Antibodies Present New Prospects to Counter Highly Antigenically Diverse Viruses

Burton, Dennis R. ; Poignard, Pascal ; Stanfield, Robyn L. ; Wilson, Ian A.

United States: American Association for the Advancement of Science

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