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Zebrafish and medaka as models for biomedical research of bone diseases

Lleras-Forero, L. ; Winkler, C. ; Schulte-Merker, S.

Developmental biology, 2020-01, Vol.457 (2), p.191-205 [Peer Reviewed Journal]

United States: Elsevier Inc

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  • Title:
    Zebrafish and medaka as models for biomedical research of bone diseases
  • Author: Lleras-Forero, L. ; Winkler, C. ; Schulte-Merker, S.
  • Is Part Of: Developmental biology, 2020-01, Vol.457 (2), p.191-205
  • Notes: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Description: The identification of disease-causing mutations has in recent years progressed immensely due to whole genome sequencing approaches using patient material. The task accordingly is shifting from gene identification to functional analysis of putative disease-causing genes, preferably in an in vivo setting which also allows testing of drug candidates or biotherapeutics in whole animal disease models. In this review, we highlight the advances made in the field of bone diseases using small laboratory fish, focusing on zebrafish and medaka. We particularly highlight those human conditions where teleost models are available.
  • Publisher: United States: Elsevier Inc
  • Language: English
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