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A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: management strategies and economic impact

Jensen, S. B. ; Pedersen, A. M. L. ; Vissink, A. ; Andersen, E. ; Brown, C. G. ; Davies, A. N. ; Dutilh, J. ; Fulton, J. S. ; Jankovic, L. ; Lopes, N. N. F. ; Mello, A. L. S. ; Muniz, L. V. ; Murdoch-Kinch, C. A. ; Nair, R. G. ; Napeñas, J. J. ; Nogueira-Rodrigues, A. ; Saunders, D. ; Stirling, B. ; von Bültzingslöwen, I. ; Weikel, D. S. ; Elting, L. S. ; Spijkervet, F. K. L. ; Brennan, M. T.

Supportive care in cancer, 2010-08, Vol.18 (8), p.1061-1079 [Peer Reviewed Journal]

Berlin/Heidelberg: Springer-Verlag

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Title:
A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: management strategies and economic impact
Author: Jensen, S. B. ; Pedersen, A. M. L. ; Vissink, A. ; Andersen, E. ; Brown, C. G. ; Davies, A. N. ; Dutilh, J. ; Fulton, J. S. ; Jankovic, L. ; Lopes, N. N. F. ; Mello, A. L. S. ; Muniz, L. V. ; Murdoch-Kinch, C. A. ; Nair, R. G. ; Napeñas, J. J. ; Nogueira-Rodrigues, A. ; Saunders, D. ; Stirling, B. ; von Bültzingslöwen, I. ; Weikel, D. S. ; Elting, L. S. ; Spijkervet, F. K. L. ; Brennan, M. T.
Subjects: Acupuncture ; Analysis ; Antimitotic agents ; Antineoplastic agents ; blind crossover trial ; Body fluids ; Cancer ; Care and treatment ; Chemotherapy ; Complications and side effects ; containing artificial saliva ; Dentistry ; Economic aspects ; Economic impact ; Evidence-based medicine ; Humans ; hyperbaric-oxygen therapy ; intensity-modulated radiotherapy ; Lubrication and lubricants ; Medicine ; Medicine & Public Health ; Neoplasms - therapy ; Nuclear radiation ; Nursing ; Nursing Research ; Odontologi ; Oncology ; Pain Medicine ; parotid-sparing radiotherapy ; Practice Guidelines as Topic ; quality-of-life ; quantitative pertechnetate scintigraphy ; radiation-induced xerostomia ; Radiologi och bildbehandling ; Radiology, Nuclear Medicine and Medical Imaging ; Radiotherapy ; Radiotherapy, Intensity-Modulated - adverse effects ; Radiotherapy, Intensity-Modulated - methods ; Rehabilitation Medicine ; Review Article ; Salivary Gland Diseases - economics ; Salivary Gland Diseases - etiology ; Salivary Gland Diseases - therapy ; san-francisco experience ; stage nasopharyngeal carcinoma ; Systematic review ; Xerostomia ; Xerostomia - economics ; Xerostomia - etiology ; Xerostomia - therapy
Is Part Of: Supportive care in cancer, 2010-08, Vol.18 (8), p.1061-1079
Description: Purpose This systematic review aimed to assess the literature for management strategies and economic impact of salivary gland hypofunction and xerostomia induced by cancer therapies and to determine the quality of evidence-based management recommendations. Methods The electronic databases of MEDLINE/PubMed and EMBASE were searched for articles published in English since the 1989 NIH Development Consensus Conference on the Oral Complications of Cancer Therapies until 2008 inclusive. For each article, two independent reviewers extracted information regarding study design, study population, interventions, outcome measures, results, and conclusions. Results Seventy-two interventional studies met the inclusion criteria. In addition, 49 intensity-modulated radiation therapy (IMRT) studies were included as a management strategy aiming for less salivary gland damage. Management guideline recommendations were drawn up for IMRT, amifostine, muscarinic agonist stimulation, oral mucosal lubricants, acupuncture, and submandibular gland transfer. Conclusions There is evidence that salivary gland hypofunction and xerostomia induced by cancer therapies can be prevented or symptoms be minimized to some degree, depending on the type of cancer treatment. Management guideline recommendations are provided for IMRT, amifostine, muscarinic agonist stimulation, oral mucosal lubricants, acupuncture, and submandibular gland transfer. Fields of sparse literature identified included effects of gustatory and masticatory stimulation, specific oral mucosal lubricant formulas, submandibular gland transfer, acupuncture, hyperbaric oxygen treatment, management strategies in pediatric cancer populations, and the economic consequences of salivary gland hypofunction and xerostomia.
Publisher: Berlin/Heidelberg: Springer-Verlag
Language: English

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A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: management strategies and economic impact

Berlin/Heidelberg: Springer-Verlag

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