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Relationship of Blood Mercury Levels to Health Parameters in the Loggerhead Sea Turtle (Caretta caretta)

Day, Rusty D ; Segars, Al L ; Arendt, Michael D ; Lee, A Michelle ; Peden-Adams, Margie M

Environmental health perspectives, 2007-10, Vol.115 (10), p.1421-1428 [Peer Reviewed Journal]

United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare

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Title:
Relationship of Blood Mercury Levels to Health Parameters in the Loggerhead Sea Turtle (Caretta caretta)
Author: Day, Rusty D ; Segars, Al L ; Arendt, Michael D ; Lee, A Michelle ; Peden-Adams, Margie M
Subjects: Analysis and chemistry ; Animal Diseases - chemically induced ; Animals ; Aspartate Aminotransferases - blood ; Aspartate Aminotransferases - drug effects ; Atlantic Ocean ; B lymphocytes ; Blood ; Blood plasma ; Caretta caretta ; Cell Proliferation - drug effects ; Cells, Cultured ; Correlations ; Creatine Kinase - blood ; Creatine Kinase - drug effects ; Distribution ; Environmental Exposure - adverse effects ; Environmental Exposure - analysis ; Environmental Monitoring ; Health aspects ; Hematocrit ; Hematocrit - veterinary ; Immune System - drug effects ; Loggerhead turtle ; Lymphocyte Count ; Lymphocyte proliferation ; Lymphocytes ; Mercury ; Mercury - blood ; Mercury - toxicity ; Methylmercury Compounds - blood ; Methylmercury Compounds - toxicity ; Sea turtles ; Southeastern United States ; T lymphocytes ; Turtles ; Turtles - blood ; Turtles - physiology
Is Part Of: Environmental health perspectives, 2007-10, Vol.115 (10), p.1421-1428
Notes: ObjectType-Article-2
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The authors declare they have no competing financial interests.
Description: Background: Mercury is a pervasive environmental pollutant whose toxic effects have not been studied in sea turtles in spite of their threatened status and evidence of immunosuppression in diseased populations. Objectives: In the present study we investigate mercury toxicity in loggerhead sea turtles (Caretta caretta) by examining trends between blood mercury concentrations and various health parameters. Methods: Blood was collected from free-ranging turtles, and correlations between blood mercury concentrations and plasma chemistries, complete blood counts, lysozyme, and lymphocyte proliferation were examined. Lymphocytes were also harvested from free-ranging turtles and exposed in vitro to methylmercury to assess proliferative responses. Results: Blood mercury concentrations were positively correlated with hematocrit and creatine phosphokinase activity, and negatively correlated with lymphocyte cell counts and aspartate aminotransferase. Ex vivo negative correlations between blood mercury concentrations and B-cell proliferation were observed in 2001 and 2003 under optimal assay conditions. In vitro exposure of peripheral blood leukocytes to methylmercury resulted in suppression of proliferative responses for B cells (0.1 µg/g and 0.35 µg/g) and T cells (0.7 µg/g). Conclusions: The positive correlation between blood mercury concentration and hematocrit reflects the higher affinity of mercury species for erythrocytes than plasma, and demonstrates the importance of measuring hematocrit when analyzing whole blood for mercury. In vitro immunosuppression occurred at methylmercury concentrations that correspond to approximately 5% of the individuals captured in the wild. This observation and the negative correlation found ex vivo between mercury and lymphocyte numbers and mercury and B-cell proliferative responses suggests that subtle negative impacts of mercury on sea turtle immune function are possible at concentrations observed in the wild.
Publisher: United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare
Language: English

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Relationship of Blood Mercury Levels to Health Parameters in the Loggerhead Sea Turtle (Caretta caretta)

Day, Rusty D ; Segars, Al L ; Arendt, Michael D ; Lee, A Michelle ; Peden-Adams, Margie M

United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare

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