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RM-493, a Melanocortin-4 Receptor (MC4R) Agonist, Increases Resting Energy Expenditure in Obese Individuals
RM-493, a Melanocortin-4 Receptor (MC4R) Agonist, Increases Resting Energy Expenditure in Obese Individuals
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RM-493, a Melanocortin-4 Receptor (MC4R) Agonist, Increases Resting Energy Expenditure in Obese Individuals

Chen, Kong Y ; Muniyappa, Ranganath ; Abel, Brent S ; Mullins, Katherine P ; Staker, Pamela ; Brychta, Robert J ; Zhao, Xiongce ; Ring, Michael ; Psota, Tricia L ; Cone, Roger D ; Panaro, Brandon L ; Gottesdiener, Keith M ; Van der Ploeg, Lex H.T ; Reitman, Marc L ; Skarulis, Monica C

The journal of clinical endocrinology and metabolism, 2015-04, Vol.100 (4), p.1639-1645 [Periódico revisado por pares]

United States: Endocrine Society

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2
Deuterium-reinforced polyunsaturated fatty acids protect against atherosclerosis by lowering lipid peroxidation and hypercholesterolemia
Deuterium-reinforced polyunsaturated fatty acids protect against atherosclerosis by lowering lipid peroxidation and hypercholesterolemia
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Deuterium-reinforced polyunsaturated fatty acids protect against atherosclerosis by lowering lipid peroxidation and hypercholesterolemia

Berbée, Jimmy F.P ; Mol, Isabel M ; Milne, Ginger L ; Pollock, Erik ; Hoeke, Geerte ; Lütjohann, Dieter ; Monaco, Claudia ; Rensen, Patrick C.N ; van der Ploeg, Lex H.T ; Shchepinov, Mikhail S

Atherosclerosis, 2017-09, Vol.264, p.100-107 [Periódico revisado por pares]

Ireland: Elsevier B.V

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3
Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency
Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency
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Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency

Collet, Tinh-Hai ; Dubern, Béatrice ; Mokrosinski, Jacek ; Connors, Hillori ; Keogh, Julia M. ; Mendes de Oliveira, Edson ; Henning, Elana ; Poitou-Bernert, Christine ; Oppert, Jean-Michel ; Tounian, Patrick ; Marchelli, Florence ; Alili, Rohia ; Le Beyec, Johanne ; Pépin, Dominique ; Lacorte, Jean-Marc ; Gottesdiener, Andrew ; Bounds, Rebecca ; Sharma, Shubh ; Folster, Cathy ; Henderson, Bart ; O'Rahilly, Stephen ; Stoner, Elizabeth ; Gottesdiener, Keith ; Panaro, Brandon L. ; Cone, Roger D. ; Clément, Karine ; Farooqi, I. Sadaf ; Van der Ploeg, Lex H.T.

Molecular metabolism (Germany), 2017-10, Vol.6 (10), p.1321-1329 [Periódico revisado por pares]

Germany: Elsevier GmbH

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4
Current Mechanistic and Pharmacodynamic Understanding of Melanocortin-4 Receptor Activation
Current Mechanistic and Pharmacodynamic Understanding of Melanocortin-4 Receptor Activation
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Current Mechanistic and Pharmacodynamic Understanding of Melanocortin-4 Receptor Activation

Sharma, Shubh ; Garfield, Alastair S ; Shah, Bhavik ; Kleyn, Patrick ; Ichetovkin, Ilia ; Moeller, Ida Hatoum ; Mowrey, William R ; Van der Ploeg, Lex H T

Molecules (Basel, Switzerland), 2019-05, Vol.24 (10), p.1892 [Periódico revisado por pares]

Switzerland: MDPI AG

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5
Inhibition of NOTCH Signaling by Gamma Secretase Inhibitor Engages the RB Pathway and Elicits Cell Cycle Exit in T-Cell Acute Lymphoblastic Leukemia Cells
Inhibition of NOTCH Signaling by Gamma Secretase Inhibitor Engages the RB Pathway and Elicits Cell Cycle Exit in T-Cell Acute Lymphoblastic Leukemia Cells
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Inhibition of NOTCH Signaling by Gamma Secretase Inhibitor Engages the RB Pathway and Elicits Cell Cycle Exit in T-Cell Acute Lymphoblastic Leukemia Cells

RAO, Sudhir S ; O'NEIL, Jennifer ; VAN DER PLOEG, Lex H. T ; CARROLL, Pamela M ; DRAETTA, Giulio F ; LOOK, A. Thomas ; STACK, Peter R ; WINTER, Christopher G ; LIBERATOR, Cole D ; HARDWICK, James S ; XUDONG DAI ; ZHANG, Theresa ; TYMINSKI, Edyta ; JING YUAN ; KOHL, Nancy E ; RICHON, Victoria M

Cancer research (Chicago, Ill.), 2009-04, Vol.69 (7), p.3060-3068 [Periódico revisado por pares]

Philadelphia, PA: American Association for Cancer Research

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6
Deuterium‐Stabilized (R)‐Pioglitazone (PXL065) Is Responsible for Pioglitazone Efficacy in NASH yet Exhibits Little to No PPARγ Activity
Deuterium‐Stabilized (R)‐Pioglitazone (PXL065) Is Responsible for Pioglitazone Efficacy in NASH yet Exhibits Little to No PPARγ Activity
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Deuterium‐Stabilized (R)‐Pioglitazone (PXL065) Is Responsible for Pioglitazone Efficacy in NASH yet Exhibits Little to No PPARγ Activity

Jacques, Vincent ; Bolze, Sébastien ; Hallakou‐Bozec, Sophie ; Czarnik, Anthony W. ; Divakaruni, Ajit S. ; Fouqueray, Pascale ; Murphy, Anne N. ; Van der Ploeg, Lex H.T. ; DeWitt, Sheila

Hepatology communications, 2021-08, Vol.5 (8), p.1412-1425 [Periódico revisado por pares]

United States: Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins

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7
Orphan G-protein-coupled receptors and natural ligand discovery
Orphan G-protein-coupled receptors and natural ligand discovery
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Orphan G-protein-coupled receptors and natural ligand discovery

Howard, Andrew D ; McAllister, George ; Feighner, Scott D ; Liu, Qingyun ; Nargund, Ravi P ; Van der Ploeg, Lex H.T ; Patchett, Arthur A

Trends in Pharmacological Sciences, 2001-03, Vol.22 (3), p.132-140 [Periódico revisado por pares]

England: Elsevier Ltd

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8
Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass
Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass
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Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

Van der Ploeg, Lex H.T ; Chen, Airu S ; Marsh, Donald J ; Trumbauer, Myrna E ; Frazier, Easter G ; Guan, Xiao-Ming ; Yu, Hong ; Rosenblum, Charles I ; Vongs, Aurawan ; Feng, Yue ; Cao, Linhai ; Metzger, Joseph M ; Strack, Alison M ; Camacho, Ramon E ; Mellin, Theodore N ; Nunes, Christian N ; Min, William ; Fisher, Jill ; Gopal-Truter, Shobhna ; MacIntyre, D. Euan ; Chen, Howard Y

Nature genetics, 2000-09, Vol.26 (1), p.97-102 [Periódico revisado por pares]

London: Nature Publishing Group

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9
Melanin-Concentrating Hormone Receptor Subtypes 1 and 2: Species-Specific Gene Expression
Melanin-Concentrating Hormone Receptor Subtypes 1 and 2: Species-Specific Gene Expression
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Melanin-Concentrating Hormone Receptor Subtypes 1 and 2: Species-Specific Gene Expression

Tan, Carina P. ; Sano, Hideki ; Iwaasa, Hisashi ; Pan, Jie ; Sailer, Andreas W. ; Hreniuk, Donna L. ; Feighner, Scott D. ; Palyha, Oksana C. ; Pong, Sheng-Shung ; Figueroa, David J. ; Austin, Christopher P. ; Jiang, Michael M. ; Yu, Hong ; Ito, Junko ; Ito, Makoto ; Ito, Masahiko ; Guan, Xiao Ming ; MacNeil, Douglas J. ; Kanatani, Akio ; Van der Ploeg, Lex H.T. ; Howard, Andrew D.

Genomics (San Diego, Calif.), 2002-06, Vol.79 (6), p.785-792 [Periódico revisado por pares]

San Diego, CA: Elsevier Inc

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10
Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats
Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats
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Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats

Shearman, Lauren P. ; Camacho, Ramon E. ; Sloan Stribling, D. ; Zhou, Dan ; Bednarek, Maria A. ; Hreniuk, Donna L. ; Feighner, Scott D. ; Tan, Carina P. ; Howard, Andrew D. ; Van der Ploeg, Lex H.T. ; MacIntyre, D.Euan ; Hickey, Gerard J. ; Strack, Alison M.

European journal of pharmacology, 2003-08, Vol.475 (1), p.37-47 [Periódico revisado por pares]

Amsterdam: Elsevier B.V

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