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Refinado por: data de publicação: 2000Até2012 remover
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1
Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions
Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions
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Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions

Sutherland, John D ; Powner, Matthew W ; Gerland, Béatrice

Nature, 2009-05, Vol.459 (7244), p.239-242 [Periódico revisado por pares]

London: Nature Publishing Group

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2
Design and Synthesis of Classical and Nonclassical 6-Arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as Antifolates
Design and Synthesis of Classical and Nonclassical 6-Arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as Antifolates
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Design and Synthesis of Classical and Nonclassical 6-Arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as Antifolates

Gangjee, Aleem ; Zeng, Yibin ; Talreja, Tina ; McGuire, John J ; Kisliuk, Roy L ; Queener, Sherry F

Journal of medicinal chemistry, 2007-06, Vol.50 (13), p.3046-3053 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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3
Synthesis and antitumor activity of new sulfonamide derivatives of thiadiazolo[3,2- a]pyrimidines
Synthesis and antitumor activity of new sulfonamide derivatives of thiadiazolo[3,2- a]pyrimidines
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Synthesis and antitumor activity of new sulfonamide derivatives of thiadiazolo[3,2- a]pyrimidines

El-Sayed, Nadia S. ; El-Bendary, Eman R. ; El-Ashry, Saadia M. ; El-Kerdawy, Mohammed M.

European journal of medicinal chemistry, 2011-09, Vol.46 (9), p.3714-3720 [Periódico revisado por pares]

Kidlington: Elsevier Masson SAS

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4
Discovery of 7‑Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro‑1H‑indol-5-yl)‑7H‑pyrrolo[2,3‑d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)
Discovery of 7‑Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro‑1H‑indol-5-yl)‑7H‑pyrrolo[2,3‑d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)
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Discovery of 7‑Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro‑1H‑indol-5-yl)‑7H‑pyrrolo[2,3‑d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

Axten, Jeffrey M ; Medina, Jesús R ; Feng, Yanhong ; Shu, Arthur ; Romeril, Stuart P ; Grant, Seth W ; Li, William Hoi Hong ; Heerding, Dirk A ; Minthorn, Elisabeth ; Mencken, Thomas ; Atkins, Charity ; Liu, Qi ; Rabindran, Sridhar ; Kumar, Rakesh ; Hong, Xuan ; Goetz, Aaron ; Stanley, Thomas ; Taylor, J. David ; Sigethy, Scott D ; Tomberlin, Ginger H ; Hassell, Annie M ; Kahler, Kirsten M ; Shewchuk, Lisa M ; Gampe, Robert T

Journal of medicinal chemistry, 2012-08, Vol.55 (16), p.7193-7207 [Periódico revisado por pares]

United States: American Chemical Society

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5
Synthesis and Antiviral Screening of Some Thieno[2,3-d]Pyrimidine Nucleosides
Synthesis and Antiviral Screening of Some Thieno[2,3-d]Pyrimidine Nucleosides
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Synthesis and Antiviral Screening of Some Thieno[2,3-d]Pyrimidine Nucleosides

Rashad, A. E. ; Ali, M. A.

Nucleosides, nucleotides & nucleic acids, 2006-01, Vol.25 (1), p.17-28 [Periódico revisado por pares]

United States: Taylor & Francis Group

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6
Design and Synthesis of Novel Human Epidermal Growth Factor Receptor 2 (HER2)/Epidermal Growth Factor Receptor (EGFR) Dual Inhibitors Bearing a Pyrrolo[3,2-d]pyrimidine Scaffold
Design and Synthesis of Novel Human Epidermal Growth Factor Receptor 2 (HER2)/Epidermal Growth Factor Receptor (EGFR) Dual Inhibitors Bearing a Pyrrolo[3,2-d]pyrimidine Scaffold
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Design and Synthesis of Novel Human Epidermal Growth Factor Receptor 2 (HER2)/Epidermal Growth Factor Receptor (EGFR) Dual Inhibitors Bearing a Pyrrolo[3,2-d]pyrimidine Scaffold

Ishikawa, Tomoyasu ; Seto, Masaki ; Banno, Hiroshi ; Kawakita, Youichi ; Oorui, Mami ; Taniguchi, Takahiko ; Ohta, Yoshikazu ; Tamura, Toshiya ; Nakayama, Akiko ; Miki, Hiroshi ; Kamiguchi, Hidenori ; Tanaka, Toshimasa ; Habuka, Noriyuki ; Sogabe, Satoshi ; Yano, Jason ; Aertgeerts, Kathleen ; Kamiyama, Keiji

J. Med. Chem, 2011-12, Vol.54 (23), p.8030-8050 [Periódico revisado por pares]

United States: American Chemical Society

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7
Efficient Preparation of 2,4-Diaminopyrimidine Nucleosides: Total Synthesis of Lysidine and Agmatidine
Efficient Preparation of 2,4-Diaminopyrimidine Nucleosides: Total Synthesis of Lysidine and Agmatidine
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Efficient Preparation of 2,4-Diaminopyrimidine Nucleosides: Total Synthesis of Lysidine and Agmatidine

Kopina, Brett J ; Lauhon, Charles T

Organic letters, 2012-08, Vol.14 (16), p.4118-4121 [Periódico revisado por pares]

United States: American Chemical Society

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8
Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines As Imaging Agents for Tau Fibrils and β‑Amyloid Plaques in Alzheimer’s Disease Models
Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines As Imaging Agents for Tau Fibrils and β‑Amyloid Plaques in Alzheimer’s Disease Models
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Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines As Imaging Agents for Tau Fibrils and β‑Amyloid Plaques in Alzheimer’s Disease Models

Boländer, Alexander ; Kieser, Daniel ; Voss, Constantin ; Bauer, Silvia ; Schön, Christian ; Burgold, Steffen ; Bittner, Tobias ; Hölzer, Jana ; Heyny-von Haußen, Roland ; Mall, Gerhard ; Goetschy, Valérie ; Czech, Christian ; Knust, Henner ; Berger, Robert ; Herms, Jochen ; Hilger, Ingrid ; Schmidt, Boris

Journal of medicinal chemistry, 2012-11, Vol.55 (21), p.9170-9180 [Periódico revisado por pares]

United States: American Chemical Society

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9
Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential
Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential
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Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

Coteron, Jose M ; Marco, María ; Esquivias, Jorge ; Deng, Xiaoyi ; White, Karen L ; White, John ; Koltun, Maria ; El Mazouni, Farah ; Kokkonda, Sreekanth ; Katneni, Kasiram ; Bhamidipati, Ravi ; Shackleford, David M ; Angulo-Barturen, Iñigo ; Ferrer, Santiago B ; Jiménez-Díaz, María Belén ; Gamo, Francisco-Javier ; Goldsmith, Elizabeth J ; Charman, William N ; Bathurst, Ian ; Floyd, David ; Matthews, David ; Burrows, Jeremy N ; Rathod, Pradipsinh K ; Charman, Susan A ; Phillips, Margaret A

Journal of medicinal chemistry, 2011-08, Vol.54 (15), p.5540-5561 [Periódico revisado por pares]

United States: American Chemical Society

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10
Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase
Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase
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Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase

Guagnano, Vito ; Furet, Pascal ; Spanka, Carsten ; Bordas, Vincent ; Le Douget, Mickaël ; Stamm, Christelle ; Brueggen, Josef ; Jensen, Michael R ; Schnell, Christian ; Schmid, Herbert ; Wartmann, Markus ; Berghausen, Joerg ; Drueckes, Peter ; Zimmerlin, Alfred ; Bussiere, Dirksen ; Murray, Jeremy ; Graus Porta, Diana

Journal of medicinal chemistry, 2011-10, Vol.54 (20), p.7066-7083 [Periódico revisado por pares]

United States: American Chemical Society

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