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1
Metabolism, Excretion, and Pharmacokinetics of [14C]INCB018424, a Selective Janus Tyrosine Kinase 1/2 Inhibitor, in Humans
Metabolism, Excretion, and Pharmacokinetics of [14C]INCB018424, a Selective Janus Tyrosine Kinase 1/2 Inhibitor, in Humans
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Metabolism, Excretion, and Pharmacokinetics of [14C]INCB018424, a Selective Janus Tyrosine Kinase 1/2 Inhibitor, in Humans

SHILLING, Adam D ; NEDZA, Frank M ; SHEPARD, Stacey ; RODGERS, James ; YUE, Tai-Yuen ; YELESWARAM, Swamy ; EMM, Thomas ; DIAMOND, Sharon ; MCKEEVER, Edward ; PUNWANI, Naresh ; WILLIAMS, William ; ARVANITIS, Argyrios ; GALYA, Laurine G ; MEI LI

Drug metabolism and disposition, 2010-11, Vol.38 (11), p.2023-2031 [Periódico revisado por pares]

Bethesda, MD: American Society for Pharmacology and Experimental Therapeutics

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2
Efficacy and Safety of Oral Janus Kinase 1 Inhibitor Abrocitinib for Patients With Atopic Dermatitis: A Phase 2 Randomized Clinical Trial
Efficacy and Safety of Oral Janus Kinase 1 Inhibitor Abrocitinib for Patients With Atopic Dermatitis: A Phase 2 Randomized Clinical Trial
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Efficacy and Safety of Oral Janus Kinase 1 Inhibitor Abrocitinib for Patients With Atopic Dermatitis: A Phase 2 Randomized Clinical Trial

Gooderham, Melinda J ; Forman, Seth B ; Bissonnette, Robert ; Beebe, Jean S ; Zhang, Weidong ; Banfield, Chris ; Zhu, Linda ; Papacharalambous, Jocelyne ; Vincent, Michael S ; Peeva, Elena

Archives of dermatology (1960), 2019-12, Vol.155 (12), p.1371-1379 [Periódico revisado por pares]

United States: American Medical Association

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3
The molecular basis of JAK/STAT inhibition by SOCS1
The molecular basis of JAK/STAT inhibition by SOCS1
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The molecular basis of JAK/STAT inhibition by SOCS1

Liau, Nicholas P D ; Laktyushin, Artem ; Lucet, Isabelle S ; Murphy, James M ; Yao, Shenggen ; Whitlock, Eden ; Callaghan, Kimberley ; Nicola, Nicos A ; Kershaw, Nadia J ; Babon, Jeffrey J

Nature communications, 2018-04, Vol.9 (1), p.1558-14, Article 1558 [Periódico revisado por pares]

England: Nature Publishing Group

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4
The molecular regulation of Janus kinase (JAK) activation
The molecular regulation of Janus kinase (JAK) activation
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The molecular regulation of Janus kinase (JAK) activation

Babon, Jeffrey J ; Lucet, Isabelle S ; Murphy, James M ; Nicola, Nicos A ; Varghese, Leila N

Biochemical journal, 2014-08, Vol.462 (1), p.1-13 [Periódico revisado por pares]

England

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5
Structure of the pseudokinase–kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition
Structure of the pseudokinase–kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition
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Structure of the pseudokinase–kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition

Lupardus, Patrick J. ; Ultsch, Mark ; Wallweber, Heidi ; Kohli, Pawan Bir ; Johnson, Adam R. ; Eigenbrot, Charles

Proceedings of the National Academy of Sciences - PNAS, 2014-06, Vol.111 (22), p.8025-8030 [Periódico revisado por pares]

United States: National Academy of Sciences

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6
Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation
Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation
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Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation

Glassman, Caleb R ; Tsutsumi, Naotaka ; Saxton, Robert A ; Lupardus, Patrick J ; Jude, Kevin M ; Garcia, K Christopher

Science (American Association for the Advancement of Science), 2022-04, Vol.376 (6589), p.163-169 [Periódico revisado por pares]

United States: The American Association for the Advancement of Science

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7
Heterodimeric JAK―STAT activation as a mechanism of persistence to JAK2 inhibitor therapy
Heterodimeric JAK―STAT activation as a mechanism of persistence to JAK2 inhibitor therapy
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Heterodimeric JAK―STAT activation as a mechanism of persistence to JAK2 inhibitor therapy

KOPPIKAR, Priya ; BHAGWAT, Neha ; LEUNG, Laura ; WEINSTEIN, Abby ; MARUBAYASHI, Sachie ; GOEL, Aviva ; GÖNEN, Mithat ; ESTROV, Zeev ; EBERT, Benjamin L ; CHIOSIS, Gabriela ; NIMER, Stephen D ; BERNSTEIN, Bradley E ; KILPIVAARA, Outi ; VERSTOVSEK, Srdan ; LEVINE, Ross L ; MANSHOURI, Taghi ; ADLI, Mazhar ; HRICIK, Todd ; FAN LIU ; SAUNDERS, Lindsay M ; MULLALLY, Ann ; ABDEL-WAHAB, Omar

Nature (London), 2012-09, Vol.489 (7414), p.155-159 [Periódico revisado por pares]

London: Nature Publishing Group

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8
Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy
Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy
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Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy

Porpaczy, Edit ; Tripolt, Sabrina ; Hoelbl-Kovacic, Andrea ; Gisslinger, Bettina ; Bago-Horvath, Zsuzsanna ; Casanova-Hevia, Emilio ; Clappier, Emmanuelle ; Decker, Thomas ; Fajmann, Sabine ; Fux, Daniela A. ; Greiner, Georg ; Gueltekin, Sinan ; Heller, Gerwin ; Herkner, Harald ; Hoermann, Gregor ; Kiladjian, Jean-Jacques ; Kolbe, Thomas ; Kornauth, Christoph ; Krauth, Maria-Theresa ; Kralovics, Robert ; Muellauer, Leonhard ; Mueller, Mathias ; Prchal-Murphy, Michaela ; Putz, Eva Maria ; Raffoux, Emmanuel ; Schiefer, Ana-Iris ; Schmetterer, Klaus ; Schneckenleithner, Christine ; Simonitsch-Klupp, Ingrid ; Skrabs, Cathrin ; Sperr, Wolfgang R. ; Staber, Philipp Bernhard ; Strobl, Birgit ; Valent, Peter ; Jaeger, Ulrich ; Gisslinger, Heinz ; Sexl, Veronika

Blood, 2018-08, Vol.132 (7), p.694-706 [Periódico revisado por pares]

United States: Elsevier Inc

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9
Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages
Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages
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Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages

Runtsch, Marah C. ; Angiari, Stefano ; Hooftman, Alexander ; Wadhwa, Ridhima ; Zhang, Yanling ; Zheng, Yunan ; Spina, Joseph S. ; Ruzek, Melanie C. ; Argiriadi, Maria A. ; McGettrick, Anne F. ; Mendez, Rui Santalla ; Zotta, Alessia ; Peace, Christian G. ; Walsh, Aoife ; Chirillo, Roberta ; Hams, Emily ; Fallon, Padraic G. ; Jayaraman, Ranjith ; Dua, Kamal ; Brown, Alexandra C. ; Kim, Richard Y. ; Horvat, Jay C. ; Hansbro, Philip M. ; Wang, Chu ; O’Neill, Luke A.J.

Cell metabolism, 2022-03, Vol.34 (3), p.487-501.e8 [Periódico revisado por pares]

United States: Elsevier Inc

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10
Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling
Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling
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Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling

Rutherford, Claire ; Speirs, Claire ; Williams, Jamie J L ; Ewart, Marie-Ann ; Mancini, Sarah J ; Hawley, Simon A ; Delles, Christian ; Viollet, Benoit ; Costa-Pereira, Ana P ; Baillie, George S ; Salt, Ian P ; Palmer, Timothy M

Science signaling, 2016-11, Vol.9 (453), p.ra109-ra109 [Periódico revisado por pares]

United States

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