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Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40
Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40
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Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40

Yang, Haijuan ; Jiang, Xiaolu ; Li, Buren ; Yang, Hyo J ; Miller, Meredith ; Yang, Angela ; Dhar, Ankita ; Pavletich, Nikola P

Nature (London), 2017-12, Vol.552 (7685), p.368-373 [Periódico revisado por pares]

England: Nature Publishing Group

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2
New Insights Into the Role of mTOR Signaling in the Cardiovascular System
New Insights Into the Role of mTOR Signaling in the Cardiovascular System
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New Insights Into the Role of mTOR Signaling in the Cardiovascular System

Sciarretta, Sebastiano ; Forte, Maurizio ; Frati, Giacomo ; Sadoshima, Junichi

Circulation research, 2018-02, Vol.122 (3), p.489-505 [Periódico revisado por pares]

United States: American Heart Association, Inc

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3
mTORC1 Controls Phase Separation and the Biophysical Properties of the Cytoplasm by Tuning Crowding
mTORC1 Controls Phase Separation and the Biophysical Properties of the Cytoplasm by Tuning Crowding
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mTORC1 Controls Phase Separation and the Biophysical Properties of the Cytoplasm by Tuning Crowding

Delarue, M. ; Brittingham, G.P. ; Pfeffer, S. ; Surovtsev, I.V. ; Pinglay, S. ; Kennedy, K.J. ; Schaffer, M. ; Gutierrez, J.I. ; Sang, D. ; Poterewicz, G. ; Chung, J.K. ; Plitzko, J.M. ; Groves, J.T. ; Jacobs-Wagner, C. ; Engel, B.D. ; Holt, L.J.

Cell, 2018-07, Vol.174 (2), p.338-349.e20 [Periódico revisado por pares]

United States: Elsevier Inc

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4
The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia
The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia
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The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia

Ham, Daniel J ; Börsch, Anastasiya ; Lin, Shuo ; Thürkauf, Marco ; Weihrauch, Martin ; Reinhard, Judith R ; Delezie, Julien ; Battilana, Fabienne ; Wang, Xueyong ; Kaiser, Marco S ; Guridi, Maitea ; Sinnreich, Michael ; Rich, Mark M ; Mittal, Nitish ; Tintignac, Lionel A ; Handschin, Christoph ; Zavolan, Mihaela ; Rüegg, Markus A

Nature communications, 2020-09, Vol.11 (1), p.4510-21, Article 4510 [Periódico revisado por pares]

England: Nature Publishing Group

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5
Glutamine and asparagine activate mTORC1 independently of Rag GTPases
Glutamine and asparagine activate mTORC1 independently of Rag GTPases
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Glutamine and asparagine activate mTORC1 independently of Rag GTPases

Meng, Delong ; Yang, Qianmei ; Wang, Huanyu ; Melick, Chase H. ; Navlani, Rishika ; Frank, Anderson R. ; Jewell, Jenna L.

The Journal of biological chemistry, 2020-03, Vol.295 (10), p.2890-2899 [Periódico revisado por pares]

United States: Elsevier Inc

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6
Second-hit mosaic mutation in mTORC1 repressor DEPDC5 causes focal cortical dysplasia-associated epilepsy
Second-hit mosaic mutation in mTORC1 repressor DEPDC5 causes focal cortical dysplasia-associated epilepsy
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Second-hit mosaic mutation in mTORC1 repressor DEPDC5 causes focal cortical dysplasia-associated epilepsy

Ribierre, Théo ; Deleuze, Charlotte ; Bacq, Alexandre ; Baldassari, Sara ; Marsan, Elise ; Chipaux, Mathilde ; Muraca, Giuseppe ; Roussel, Delphine ; Navarro, Vincent ; Leguern, Eric ; Miles, Richard ; Baulac, Stéphanie

The Journal of clinical investigation, 2018-06, Vol.128 (6), p.2452-2458 [Periódico revisado por pares]

United States: American Society for Clinical Investigation

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7
The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals
The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals
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The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

Torrence, Margaret E ; MacArthur, Michael R ; Hosios, Aaron M ; Valvezan, Alexander J ; Asara, John M ; Mitchell, James R ; Manning, Brendan D

eLife, 2021-03, Vol.10 [Periódico revisado por pares]

England: eLife Sciences Publications Ltd

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8
Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1)
Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1)
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Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1)

Shibutani, Shusaku ; Okazaki, Hana ; Iwata, Hiroyuki

The Journal of biological chemistry, 2017-11, Vol.292 (44), p.18052-18061 [Periódico revisado por pares]

United States: Elsevier Inc

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9
TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity
TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity
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TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity

Prouteau, Manoël ; Desfosses, Ambroise ; Sieben, Christian ; Bourgoint, Clélia ; Lydia Mozaffari, Nour ; Demurtas, Davide ; Mitra, Alok K ; Guichard, Paul ; Manley, Suliana ; Loewith, Robbie

Nature (London), 2017-10, Vol.550 (7675), p.265-269 [Periódico revisado por pares]

England: Nature Publishing Group

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10
In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition
In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition
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In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition

Rinaldi, Gianmarco ; Pranzini, Erica ; Van Elsen, Joke ; Broekaert, Dorien ; Funk, Cornelius M. ; Planque, Mélanie ; Doglioni, Ginevra ; Altea-Manzano, Patricia ; Rossi, Matteo ; Geldhof, Vincent ; Teoh, Shao Thing ; Ross, Christina ; Hunter, Kent W. ; Lunt, Sophia Y. ; Grünewald, Thomas G.P. ; Fendt, Sarah-Maria

Molecular cell, 2021-01, Vol.81 (2), p.386-397.e7 [Periódico revisado por pares]

United States: Elsevier Inc

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