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Engineered mini-G proteins block the internalization of cognate GPCRs and disrupt downstream intracellular signalingManchanda, Yusman ; ElEid, Liliane ; Oqua, Affiong I. ; Ramchunder, Zenouska ; Choi, Jiyoon ; Shchepinova, Maria M. ; Rutter, Guy A. ; Inoue, Asuka ; Tate, Edward W. ; Jones, Ben ; Tomas, AlejandraScience signaling, 2024-07, Vol.17 (843), p.eabq7038 [Periódico revisado por pares]Washington: The American Association for the Advancement of ScienceTexto completo disponível |
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The epithelial C15ORF48/miR-147-NDUFA4 axis is an essential regulator of gut inflammation, energy metabolism, and the microbiomeXiong, Min ; Liu, Ze ; Wang, Bintao ; Sokolich, Thomas ; Graham, Natalie ; Chen, Meirong ; Wang, Wei-Le ; Boldin, Mark P.Proceedings of the National Academy of Sciences - PNAS, 2024-07, Vol.121 (27), p.1 [Periódico revisado por pares]Washington: National Academy of SciencesTexto completo disponível |
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A metabolic inhibitor blocks cellular fucosylation and enables production of afucosylated antibodiesGilormini, Pierre-André ; Thota, V. Narasimharao ; Fers-Lidou, Anthony ; Ashmus, Roger A. ; Nodwell, Matthew ; Brockerman, Jacob ; Kuo, Chu-Wei ; Wang, Yang ; Gray, Taylor E. ; Nitin ; McDonagh, Anthony W. ; Guu, Shih-Yun ; Ertunc, Nursah ; Yeo, Dominick ; Zandberg, Wesley F. ; Khoo, Kay-Hooi ; Britton, Robert ; Vocadlo, David J.Proceedings of the National Academy of Sciences - PNAS, 2024-07, Vol.121 (27), p.1 [Periódico revisado por pares]Washington: National Academy of SciencesTexto completo disponível |
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Material Type: Artigo
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FAK loss reduces BRAFV600E-induced ERK phosphorylation to promote intestinal stemness and cecal tumor formationGao, Chenxi ; Ge, Huaibin ; Kuan, Shih-Fan ; Cai, Chunhui ; Lu, Xinghua ; Esni, Farzad ; Schoen, Robert E ; Wang, Jing H ; Chu, Edward ; Hu, JingeLife, 2024-06, Vol.13 [Periódico revisado por pares]Cambridge: eLife Sciences Publications LtdTexto completo disponível |
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Material Type: Artigo
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StaufenC facilitates utilization of the ERAD pathway to transport dsRNA through the endoplasmic reticulum to the cytosolKoo, Jinmo ; Palli, Subba ReddyProceedings of the National Academy of Sciences - PNAS, 2024-06, Vol.121 (26), p.1 [Periódico revisado por pares]Washington: National Academy of SciencesTexto completo disponível |
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Physical modeling of nucleosome clustering in euchromatin resulting from interactions between epigenetic reader proteinsWakim, Joseph G. ; Spakowitz, Andrew J.Proceedings of the National Academy of Sciences - PNAS, 2024-06, Vol.121 (26), p.1 [Periódico revisado por pares]Washington: National Academy of SciencesTexto completo disponível |
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Material Type: Artigo
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Calorie restriction and calorie-restriction mimetics activate chaperone-mediated autophagyJafari, Maryam ; Macho-González, Adrián ; Diaz, Antonio ; Lindenau, Kristen ; Santiago-Fernández, Olaya ; Zeng, Mei ; Massey, Ashish C. ; de Cabo, Rafael ; Kaushik, Susmita ; Cuervo, Ana MariaProceedings of the National Academy of Sciences - PNAS, 2024-06, Vol.121 (26), p.1 [Periódico revisado por pares]Washington: National Academy of SciencesTexto completo disponível |
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Material Type: Artigo
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Fitness landscape of substrate-adaptive mutations in evolved amino acid-polyamine-organocation transportersKarapanagioti, Foteini ; Atlason, Úlfur Águst ; Slotboom, Dirk J ; Poolman, Bert ; Obermaier, SebastianeLife, 2024-06, Vol.13 [Periódico revisado por pares]Cambridge: eLife Sciences Publications LtdTexto completo disponível |
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Material Type: Artigo
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Cytoplasmic fluidization contributes to breaking spore dormancy in fission yeastSakai, Keiichiro ; Kondo, Yohei ; Goto, Yuhei ; Aoki, KazuhiroProceedings of the National Academy of Sciences - PNAS, 2024-06, Vol.121 (26), p.1 [Periódico revisado por pares]Washington: National Academy of SciencesTexto completo disponível |
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Material Type: Artigo
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Eugenol mimics exercise to promote skeletal muscle fiber remodeling and myokine IL-15 expression by activating TRPV1 channelHuang, Tengteng ; Chen, Xiaoling ; He, Jun ; Zheng, Ping ; Luo, Yuheng ; Wu, Aimin ; Yan, Hui ; Yu, Bing ; Chen, Daiwen ; Huang, ZhiqingeLife, 2024-06, Vol.12 [Periódico revisado por pares]Cambridge: eLife Sciences Publications LtdTexto completo disponível |