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Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response
Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response
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Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response

Ali, Maruf M U ; Bagratuni, Tina ; Davenport, Emma L ; Nowak, Piotr R ; Silva-Santisteban, M Cris ; Hardcastle, Anthea ; McAndrews, Craig ; Rowlands, Martin G ; Morgan, Gareth J ; Aherne, Wynne ; Collins, Ian ; Davies, Faith E ; Pearl, Laurence H

The EMBO journal, 2011-03, Vol.30 (5), p.894-905 [Periódico revisado por pares]

Chichester, UK: John Wiley & Sons, Ltd

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2
High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity
High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity
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High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity

Rowlands, Martin G ; Newbatt, Yvette M ; Prodromou, Chrisostomos ; Pearl, Laurence H ; Workman, Paul ; Aherne, Wynne

Analytical biochemistry, 2004-04, Vol.327 (2), p.176-183 [Periódico revisado por pares]

United States: Elsevier Inc

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3
Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity
Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity
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Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity

Stimson, Lindsay ; Rowlands, Martin G ; Newbatt, Yvette M ; Smith, Nicola F ; Raynaud, Florence I ; Rogers, Paul ; Bavetsias, Vassilios ; Gorsuch, Stephen ; Jarman, Michael ; Bannister, Andrew ; Kouzarides, Tony ; McDonald, Edward ; Workman, Paul ; Aherne, G Wynne

Molecular cancer therapeutics, 2005-10, Vol.4 (10), p.1521-1532 [Periódico revisado por pares]

United States: American Association for Cancer Research

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4
Targeting the Hsp90 Chaperone: Synthesis of Novel Resorcylic Acid Macrolactone Inhibitors of Hsp90
Targeting the Hsp90 Chaperone: Synthesis of Novel Resorcylic Acid Macrolactone Inhibitors of Hsp90
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Targeting the Hsp90 Chaperone: Synthesis of Novel Resorcylic Acid Macrolactone Inhibitors of Hsp90

Day, James E. H. ; Sharp, Swee Y. ; Rowlands, Martin G. ; Aherne, Wynne ; Workman, Paul ; Moody, Christopher J.

Chemistry : a European journal, 2010-03, Vol.16 (9), p.2758-2763 [Periódico revisado por pares]

Weinheim: WILEY-VCH Verlag

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5
Rapid Evolution of 6-Phenylpurine Inhibitors of Protein Kinase B through Structure-Based Design
Rapid Evolution of 6-Phenylpurine Inhibitors of Protein Kinase B through Structure-Based Design
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Rapid Evolution of 6-Phenylpurine Inhibitors of Protein Kinase B through Structure-Based Design

Donald, Alastair ; McHardy, Tatiana ; Rowlands, Martin G ; Hunter, Lisa-Jane K ; Davies, Thomas G ; Berdini, Valerio ; Boyle, Robert G ; Aherne, G. Wynne ; Garrett, Michelle D ; Collins, Ian

Journal of medicinal chemistry, 2007-05, Vol.50 (10), p.2289-2292 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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6
Inhibition of Hsp90 with Resorcylic Acid Macrolactones: Synthesis and Binding Studies
Inhibition of Hsp90 with Resorcylic Acid Macrolactones: Synthesis and Binding Studies
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Inhibition of Hsp90 with Resorcylic Acid Macrolactones: Synthesis and Binding Studies

Day, James E. H. ; Sharp, Swee Y. ; Rowlands, Martin G. ; Aherne, Wynne ; Lewis, William ; Roe, S. Mark ; Prodromou, Chrisostomos ; Pearl, Laurence H. ; Workman, Paul ; Moody, Christopher J.

Chemistry : a European journal, 2010-09, Vol.16 (34), p.10366-10372 [Periódico revisado por pares]

Weinheim: WILEY-VCH Verlag

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7
Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B
Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B
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Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B

Collins, Ian ; Caldwell, John ; Fonseca, Tatiana ; Donald, Alastair ; Bavetsias, Vassilios ; Hunter, Lisa-Jane K. ; Garrett, Michelle D. ; Rowlands, Martin G. ; Aherne, G. Wynne ; Davies, Thomas G. ; Berdini, Valerio ; Woodhead, Steven J. ; Davis, Deborah ; Seavers, Lisa C.A. ; Wyatt, Paul G. ; Workman, Paul ; McDonald, Edward

Bioorganic & medicinal chemistry, 2006-02, Vol.14 (4), p.1255-1273 [Periódico revisado por pares]

Oxford: Elsevier Ltd

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8
Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays
Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays
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Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays

Pierrat, Olivier A ; Liu, Manjuan ; Collie, Gavin W ; Shetty, Kartika ; Rodrigues, Matthew J ; Le Bihan, Yann-Vaï ; Gunnell, Emma A ; McAndrew, P Craig ; Stubbs, Mark ; Rowlands, Martin G ; Yahya, Norhakim ; Shehu, Erald ; Talbot, Rachel ; Pickard, Lisa ; Bellenie, Benjamin R ; Cheung, Kwai-Ming J ; Drouin, Ludovic ; Innocenti, Paolo ; Woodward, Hannah ; Davis, Owen A ; Lloyd, Matthew G ; Varela, Ana ; Huckvale, Rosemary ; Broccatelli, Fabio ; Carter, Michael ; Galiwango, David ; Hayes, Angela ; Raynaud, Florence I ; Bryant, Christopher ; Whittaker, Steven ; Rossanese, Olivia W ; Hoelder, Swen ; Burke, Rosemary ; van Montfort, Rob L M

Scientific reports, 2022-11, Vol.12 (1), p.18633-18633, Article 18633 [Periódico revisado por pares]

England: Nature Publishing Group

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9
Establishment and Characterization of Acquired Resistance to the Farnesyl Protein Transferase Inhibitor R115777 in a Human Colon Cancer Cell Line
Establishment and Characterization of Acquired Resistance to the Farnesyl Protein Transferase Inhibitor R115777 in a Human Colon Cancer Cell Line
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Establishment and Characterization of Acquired Resistance to the Farnesyl Protein Transferase Inhibitor R115777 in a Human Colon Cancer Cell Line

SMITH, Victoria ; ROWLANDS, Martin G ; BARRIE, Elaine ; WORKMAN, Paul ; KELLAND, Lloyd R

Clinical cancer research, 2002-06, Vol.8 (6), p.2002-2009 [Periódico revisado por pares]

Philadelphia, PA: American Association for Cancer Research

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10
A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms
A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms
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A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms

Jones, Alan M ; Westwood, Isaac M ; Osborne, James D ; Matthews, Thomas P ; Cheeseman, Matthew D ; Rowlands, Martin G ; Jeganathan, Fiona ; Burke, Rosemary ; Lee, Diane ; Kadi, Nadia ; Liu, Manjuan ; Richards, Meirion ; McAndrew, Craig ; Yahya, Norhakim ; Dobson, Sarah E ; Jones, Keith ; Workman, Paul ; Collins, Ian ; van Montfort, Rob L M

Scientific reports, 2016-10, Vol.6 (1), p.34701-34701, Article 34701 [Periódico revisado por pares]

England: Nature Publishing Group

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