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Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders
Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders
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Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders

Cisar, Justin S ; Weber, Olivia D ; Clapper, Jason R ; Blankman, Jacqueline L ; Henry, Cassandra L ; Simon, Gabriel M ; Alexander, Jessica P ; Jones, Todd K ; Ezekowitz, R. Alan B ; O’Neill, Gary P ; Grice, Cheryl A

Journal of medicinal chemistry, 2018-10, Vol.61 (20), p.9062-9084 [Periódico revisado por pares]

United States: American Chemical Society

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2
The Discovery of LML134, a Histamine H3 Receptor Inverse Agonist for the Clinical Treatment of Excessive Sleep Disorders
The Discovery of LML134, a Histamine H3 Receptor Inverse Agonist for the Clinical Treatment of Excessive Sleep Disorders
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The Discovery of LML134, a Histamine H3 Receptor Inverse Agonist for the Clinical Treatment of Excessive Sleep Disorders

Troxler, Thomas ; Feuerbach, Dominik ; Zhang, Xuechun ; Yang, Charles R. ; Lagu, Bharat ; Perrone, Mark ; Wang, Tie‐Lin ; Briner, Karin ; Bock, Mark G. ; Auberson, Yves P.

ChemMedChem, 2019-07, Vol.14 (13), p.1238-1247 [Periódico revisado por pares]

Germany: Wiley Subscription Services, Inc

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3
Sotorasib: First Approval
Sotorasib: First Approval
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Sotorasib: First Approval

Blair, Hannah A.

Drugs (New York, N.Y.), 2021-09, Vol.81 (13), p.1573-1579 [Periódico revisado por pares]

Cham: Springer International Publishing

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4
Safety and Clinical Activity of the Programmed Death-Ligand 1 Inhibitor Durvalumab in Combination With Poly (ADP-Ribose) Polymerase Inhibitor Olaparib or Vascular Endothelial Growth Factor Receptor 1-3 Inhibitor Cediranib in Women's Cancers: A Dose-Escalation, Phase I Study
Safety and Clinical Activity of the Programmed Death-Ligand 1 Inhibitor Durvalumab in Combination With Poly (ADP-Ribose) Polymerase Inhibitor Olaparib or Vascular Endothelial Growth Factor Receptor 1-3 Inhibitor Cediranib in Women's Cancers: A Dose-Escalation, Phase I Study
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Safety and Clinical Activity of the Programmed Death-Ligand 1 Inhibitor Durvalumab in Combination With Poly (ADP-Ribose) Polymerase Inhibitor Olaparib or Vascular Endothelial Growth Factor Receptor 1-3 Inhibitor Cediranib in Women's Cancers: A Dose-Escalation, Phase I Study

Lee, Jung-Min ; Cimino-Mathews, Ashley ; Peer, Cody J ; Zimmer, Alexandra ; Lipkowitz, Stanley ; Annunziata, Christina M ; Cao, Liang ; Harrell, Maria I ; Swisher, Elizabeth M ; Houston, Nicole ; Botesteanu, Dana-Adriana ; Taube, Janis M ; Thompson, Elizabeth ; Ogurtsova, Aleksandra ; Xu, Haiying ; Nguyen, Jeffers ; Ho, Tony W ; Figg, William D ; Kohn, Elise C

Journal of clinical oncology, 2017-07, Vol.35 (19), p.2193-2202 [Periódico revisado por pares]

United States: American Society of Clinical Oncology

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5
The role of kinetic context in apparent biased agonism at GPCRs
The role of kinetic context in apparent biased agonism at GPCRs
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The role of kinetic context in apparent biased agonism at GPCRs

Klein Herenbrink, Carmen ; Sykes, David A ; Donthamsetti, Prashant ; Canals, Meritxell ; Coudrat, Thomas ; Shonberg, Jeremy ; Scammells, Peter J ; Capuano, Ben ; Sexton, Patrick M ; Charlton, Steven J ; Javitch, Jonathan A ; Christopoulos, Arthur ; Lane, J Robert

Nature communications, 2016-02, Vol.7 (1), p.10842-10842, Article 10842 [Periódico revisado por pares]

England: Nature Publishing Group

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6
AZD4547: An Orally Bioavailable, Potent, and Selective Inhibitor of the Fibroblast Growth Factor Receptor Tyrosine Kinase Family
AZD4547: An Orally Bioavailable, Potent, and Selective Inhibitor of the Fibroblast Growth Factor Receptor Tyrosine Kinase Family
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AZD4547: An Orally Bioavailable, Potent, and Selective Inhibitor of the Fibroblast Growth Factor Receptor Tyrosine Kinase Family

GAVINE, Paul R ; MOONEY, Lorraine ; NIGEL BROOKS, A ; KLINOWSKA, Teresa ; KILGOUR, Elaine ; THOMAS, Andrew P ; AL-KADHIMI, Katherine ; BECK, Sarah ; ROONEY, Claire ; COLEMAN, Tanya ; BAKER, Dawn ; MELLOR, Martine J

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8), p.2045-2056 [Periódico revisado por pares]

Philadelphia, PA: American Association for Cancer Research

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7
Use of PER977 to Reverse the Anticoagulant Effect of Edoxaban
Use of PER977 to Reverse the Anticoagulant Effect of Edoxaban
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Use of PER977 to Reverse the Anticoagulant Effect of Edoxaban

Ansell, Jack E ; Bakhru, Sasha H ; Laulicht, Bryan E ; Steiner, Solomon S ; Grosso, Michael ; Brown, Karen ; Dishy, Victor ; Noveck, Robert J ; Costin, James C

The New England journal of medicine, 2014-11, Vol.371 (22), p.2141-2142 [Periódico revisado por pares]

United States: Massachusetts Medical Society

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8
Pharmacokinetic and pharmacodynamic actions of clozapine-N-oxide, clozapine, and compound 21 in DREADD-based chemogenetics in mice
Pharmacokinetic and pharmacodynamic actions of clozapine-N-oxide, clozapine, and compound 21 in DREADD-based chemogenetics in mice
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Pharmacokinetic and pharmacodynamic actions of clozapine-N-oxide, clozapine, and compound 21 in DREADD-based chemogenetics in mice

Jendryka, Martin ; Palchaudhuri, Monika ; Ursu, Daniel ; van der Veen, Bastiaan ; Liss, Birgit ; Kätzel, Dennis ; Nissen, Wiebke ; Pekcec, Anton

Scientific reports, 2019-03, Vol.9 (1), p.4522, Article 4522 [Periódico revisado por pares]

England: Nature Publishing Group

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9
A Phase Ib Open-Label Multicenter Study of AZD4547 in Patients with Advanced Squamous Cell Lung Cancers
A Phase Ib Open-Label Multicenter Study of AZD4547 in Patients with Advanced Squamous Cell Lung Cancers
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A Phase Ib Open-Label Multicenter Study of AZD4547 in Patients with Advanced Squamous Cell Lung Cancers

Paik, Paul K ; Shen, Ronglai ; Berger, Michael F ; Ferry, David ; Soria, Jean-Charles ; Mathewson, Alastair ; Rooney, Claire ; Smith, Neil R ; Cullberg, Marie ; Kilgour, Elaine ; Landers, Donal ; Frewer, Paul ; Brooks, Nigel ; André, Fabrice

Clinical cancer research, 2017-09, Vol.23 (18), p.5366-5373 [Periódico revisado por pares]

United States: American Association for Cancer Research Inc

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10
Differentiating Drug-Induced Multichannel Block on the Electrocardiogram: Randomized Study of Dofetilide, Quinidine, Ranolazine, and Verapamil
Differentiating Drug-Induced Multichannel Block on the Electrocardiogram: Randomized Study of Dofetilide, Quinidine, Ranolazine, and Verapamil
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Differentiating Drug-Induced Multichannel Block on the Electrocardiogram: Randomized Study of Dofetilide, Quinidine, Ranolazine, and Verapamil

Johannesen, L ; Vicente, J ; Mason, J W ; Sanabria, C ; Waite-Labott, K ; Hong, M ; Guo, P ; Lin, J ; Sørensen, J S ; Galeotti, L ; Florian, J ; Ugander, M ; Stockbridge, N ; Strauss, D G

Clinical pharmacology and therapeutics, 2014-11, Vol.96 (5), p.549-558 [Periódico revisado por pares]

United States: Blackwell Publishing Ltd

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