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Material Type: Artigo
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A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatmentHyer, Marc L ; Milhollen, Michael A ; Ciavarri, Jeff ; Fleming, Paul ; Traore, Tary ; Sappal, Darshan ; Huck, Jessica ; Shi, Judy ; Gavin, James ; Brownell, Jim ; Yang, Yu ; Stringer, Bradley ; Griffin, Robert ; Bruzzese, Frank ; Soucy, Teresa ; Duffy, Jennifer ; Rabino, Claudia ; Riceberg, Jessica ; Hoar, Kara ; Lublinsky, Anya ; Menon, Saurabh ; Sintchak, Michael ; Bump, Nancy ; Pulukuri, Sai M ; Langston, Steve ; Tirrell, Stephen ; Kuranda, Mike ; Veiby, Petter ; Newcomb, John ; Li, Ping ; Wu, Jing Tao ; Powe, Josh ; Dick, Lawrence R ; Greenspan, Paul ; Galvin, Katherine ; Manfredi, Mark ; Claiborne, Chris ; Amidon, Benjamin S ; Bence, Neil FNature medicine, 2018-02, Vol.24 (2), p.186-193 [Periódico revisado por pares]United States: Nature Publishing GroupTexto completo disponível |
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Material Type: Artigo
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Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of CancerLangston, Steven P ; Grossman, Stephen ; England, Dylan ; Afroze, Roushan ; Bence, Neil ; Bowman, Douglas ; Bump, Nancy ; Chau, Ryan ; Chuang, Bei-Ching ; Claiborne, Christopher ; Cohen, Larry ; Connolly, Kelly ; Duffey, Matthew ; Durvasula, Nitya ; Freeze, Scott ; Gallery, Melissa ; Galvin, Katherine ; Gaulin, Jeffrey ; Gershman, Rachel ; Greenspan, Paul ; Grieves, Jessica ; Guo, Jianping ; Gulavita, Nanda ; Hailu, Shumet ; He, Xingyue ; Hoar, Kara ; Hu, Yongbo ; Hu, Zhigen ; Ito, Mitsuhiro ; Kim, Mi-Sook ; Lane, Scott Weston ; Lok, David ; Lublinsky, Anya ; Mallender, William ; McIntyre, Charles ; Minissale, James ; Mizutani, Hirotake ; Mizutani, Miho ; Molchinova, Nina ; Ono, Koji ; Patil, Ashok ; Qian, Mark ; Riceberg, Jessica ; Shindi, Vaishali ; Sintchak, Michael D ; Song, Keli ; Soucy, Teresa ; Wang, Yana ; Xu, He ; Yang, Xiaofeng ; Zawadzka, Agatha ; Zhang, Ji ; Pulukuri, Sai MJournal of medicinal chemistry, 2021-03, Vol.64 (5), p.2501-2520 [Periódico revisado por pares]United States: American Chemical SocietyTexto completo disponível |
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Material Type: Artigo
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Characterization of the loss of SUMO pathway function on cancer cells and tumor proliferationHe, Xingyue ; Riceberg, Jessica ; Pulukuri, Sai M ; Grossman, Steve ; Shinde, Vaishali ; Shah, Pooja ; Brownell, James E ; Dick, Larry ; Newcomb, John ; Bence, Neil Maki, Carl G.PloS one, 2015-04, Vol.10 (4), p.e0123882-e0123882 [Periódico revisado por pares]United States: Public Library of ScienceTexto completo disponível |
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Material Type: Artigo
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Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitorHe, Xingyue ; Riceberg, Jessica ; Soucy, Teresa ; Koenig, Erik ; Minissale, James ; Gallery, Melissa ; Bernard, Hugues ; Yang, Xiaofeng ; Liao, Hua ; Rabino, Claudia ; Shah, Pooja ; Xega, Kristina ; Yan, Zhong-Hua ; Sintchak, Mike ; Bradley, John ; Xu, He ; Duffey, Matt ; England, Dylan ; Mizutani, Hirotake ; Hu, Zhigen ; Guo, Jianping ; Chau, Ryan ; Dick, Lawrence R ; Brownell, James E ; Newcomb, John ; Langston, Steve ; Lightcap, Eric S ; Bence, Neil ; Pulukuri, Sai MNature chemical biology, 2017-11, Vol.13 (11), p.1164-1171 [Periódico revisado por pares]United States: Nature Publishing GroupTexto completo disponível |
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Material Type: Artigo
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A small-molecule SUMOylation inhibitor activates antitumor immune responses and potentiates immune therapies in preclinical modelsLightcap, Eric S ; Yu, Pengfei ; Grossman, Stephen ; Song, Keli ; Khattar, Mithun ; Xega, Kristina ; He, Xingyue ; Gavin, James M ; Imaichi, Hisashi ; Garnsey, James J ; Koenig, Erik ; Zhang, Hongru ; Lu, Zhen ; Shah, Pooja ; Fu, Yu ; Milhollen, Michael A ; Hatton, Beryl A ; Riceberg, Jessica ; Shinde, Vaishali ; Li, Cong ; Minissale, James ; Yang, Xiaofeng ; England, Dylan ; Klinghoffer, Richard A ; Langston, Steve ; Galvin, Katherine ; Shapiro, Gary ; Pulukuri, Sai M ; Fuchs, Serge Y ; Huszar, DennisScience translational medicine, 2021-09, Vol.13 (611), p.eaba7791-eaba7791 [Periódico revisado por pares]United States: The American Association for the Advancement of ScienceTexto completo disponível |
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Material Type: Artigo
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Synergy of an anti-HER2 ADC TAK-522 (XMT-1522) in combination with anti-PD1 monoclonal antibody (mAb) in a syngeneic breast cancer model expressing human HER2Khattar, Mithun ; Traore, Tary ; Horton, Kristin ; Gallery, Melissa ; Brauer, Pamela ; Riceberg, Jessica ; Bodyak, Natalya ; Protopopova, Marina ; Zhang, Qingxiu ; Lowinger, Timothy B. ; Veiby, Petter ; Huszar, Dennis ; Wang, FrankThe Journal of immunology (1950), 2018-05, Vol.200 (1_Supplement), p.122-122.29 [Periódico revisado por pares]Texto completo disponível |
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Material Type: Artigo
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Treatment-Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924Milhollen, Michael A. ; Thomas, Michael P. ; Narayanan, Usha ; Traore, Tary ; Riceberg, Jessica ; Amidon, Benjamin S. ; Bence, Neil F. ; Bolen, Joseph B. ; Brownell, James ; Dick, Lawrence R. ; Loke, Huay-Keng ; McDonald, Alice A. ; Ma, Jingya ; Manfredi, Mark G. ; Sells, Todd B. ; Sintchak, Mike D. ; Yang, Xiaofeng ; Xu, Qing ; Koenig, Erik M. ; Gavin, James M. ; Smith, Peter G.Cancer cell, 2012-03, Vol.21 (3), p.388-401 [Periódico revisado por pares]United States: Elsevier IncTexto completo disponível |
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Material Type: Artigo
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Abstract 1147: Probing the roles of SUMOylation in cancer cell biology using a selective SUMO activating enzyme inhibitorPulukuri, Sai M ; He, Xingyue ; Grossman, Stephen ; Riceberg, Jessica ; Koenig, Erik ; Soucy, Teresa ; Song, Keli ; Kreshock, Anna ; England, Dylan ; Mizutani, Hirotake ; Dick, Larry ; Brownell, James ; Newcomb, John ; Langston, Steve ; Lightcap, Eric ; Galvin, KatherineCancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.1147-1147 [Periódico revisado por pares]Texto completo disponível |
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Material Type: Artigo
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Treatment Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924 in Pre-Clinical AML and DLBCL ModelsMilhollen, Michael ; Thomas, Michael ; Traore, Tary ; Narayanan, Usha ; Riceberg, Jessica ; Sells, Todd ; Amidon, Ben ; Manfredi, Mark ; Bence, Neil ; Brownell, James ; Dick, Larry ; Koenig, Erik ; Gavin, James ; Smith, Peter GBlood, 2011-11, Vol.118 (21), p.1413-1413 [Periódico revisado por pares]Elsevier IncTexto completo disponível |
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Material Type: Artigo
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Abstract C28: Treatment emergent mutations in NAEbeta confer resistance to the investigational NEDD8-activating enzyme inhibitor MLN4924Smith, Peter G. ; Thomas, Michael ; Traore, Tary ; Narayanan, Usha ; Riceberg, Jessica ; Amidon, Ben ; Bence, Neil ; Brownell, James ; Dick, Larry ; Manfredi, Mark ; Sells, Todd ; Sintchak, Mike ; Koenig, Erik ; Gavin, James ; Milhollen, Michael A.Molecular cancer therapeutics, 2011-11, Vol.10 (11_Supplement), p.C28-C28 [Periódico revisado por pares]Texto completo disponível |