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An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19
An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19
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An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19

Owen, Dafydd R ; Allerton, Charlotte M N ; Anderson, Annaliesa S ; Aschenbrenner, Lisa ; Avery, Melissa ; Berritt, Simon ; Boras, Britton ; Cardin, Rhonda D ; Carlo, Anthony ; Coffman, Karen J ; Dantonio, Alyssa ; Di, Li ; Eng, Heather ; Ferre, RoseAnn ; Gajiwala, Ketan S ; Gibson, Scott A ; Greasley, Samantha E ; Hurst, Brett L ; Kadar, Eugene P ; Kalgutkar, Amit S ; Lee, Jack C ; Lee, Jisun ; Liu, Wei ; Mason, Stephen W ; Noell, Stephen ; Novak, Jonathan J ; Obach, R Scott ; Ogilvie, Kevin ; Patel, Nandini C ; Pettersson, Martin ; Rai, Devendra K ; Reese, Matthew R ; Sammons, Matthew F ; Sathish, Jean G ; Singh, Ravi Shankar P ; Steppan, Claire M ; Stewart, Al E ; Tuttle, Jamison B ; Updyke, Lawrence ; Verhoest, Patrick R ; Wei, Liuqing ; Yang, Qingyi ; Zhu, Yuao

Science (American Association for the Advancement of Science), 2021-12, Vol.374 (6575), p.1586-1593 [Periódico revisado por pares]

United States

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2
A review of pharmacological and pharmacokinetic properties of stachydrine
A review of pharmacological and pharmacokinetic properties of stachydrine
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A review of pharmacological and pharmacokinetic properties of stachydrine

Cheng, Fang ; Zhou, Yanxi ; Wang, Miao ; Guo, Chuanjie ; Cao, Zhixing ; Zhang, Ruoqi ; Peng, Cheng

Pharmacological research, 2020-05, Vol.155, p.104755, Article 104755 [Periódico revisado por pares]

Netherlands: Elsevier Ltd

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3
The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern
The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern
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The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern

Abdelnabi, Rana ; Foo, Caroline S ; Jochmans, Dirk ; Vangeel, Laura ; De Jonghe, Steven ; Augustijns, Patrick ; Mols, Raf ; Weynand, Birgit ; Wattanakul, Thanaporn ; Hoglund, Richard M ; Tarning, Joel ; Mowbray, Charles E ; Sjö, Peter ; Escudié, Fanny ; Scandale, Ivan ; Chatelain, Eric ; Neyts, Johan

Nature communications, 2022-02, Vol.13 (1), p.719-719, Article 719 [Periódico revisado por pares]

England: Nature Publishing Group

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4
Design and Mechanism of (S)‑3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ‑Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction
Design and Mechanism of (S)‑3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ‑Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction
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Design and Mechanism of (S)‑3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ‑Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction

Juncosa, Jose I ; Takaya, Kenji ; Le, Hoang V ; Moschitto, Matthew J ; Weerawarna, Pathum M ; Mascarenhas, Romila ; Liu, Dali ; Dewey, Stephen L ; Silverman, Richard B

Journal of the American Chemical Society, 2018-02, Vol.140 (6), p.2151-2164 [Periódico revisado por pares]

United States: American Chemical Society

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5
Anatomical accuracy of brain connections derived from diffusion MRI tractography is inherently limited
Anatomical accuracy of brain connections derived from diffusion MRI tractography is inherently limited
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Anatomical accuracy of brain connections derived from diffusion MRI tractography is inherently limited

Thomas, Cibu ; Ye, Frank Q. ; Irfanoglu, M. Okan ; Modi, Pooja ; Saleem, Kadharbatcha S. ; Leopold, David A. ; Pierpaoli, Carlo

Proceedings of the National Academy of Sciences - PNAS, 2014-11, Vol.111 (46), p.16574-16579 [Periódico revisado por pares]

United States: National Academy of Sciences

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6
Effect of Preorganized Charge‐Display on the Cell‐Penetrating Properties of Cationic Peptides
Effect of Preorganized Charge‐Display on the Cell‐Penetrating Properties of Cationic Peptides
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Effect of Preorganized Charge‐Display on the Cell‐Penetrating Properties of Cationic Peptides

Nagel, Yvonne A. ; Raschle, Philipp S. ; Wennemers, Helma

Angewandte Chemie (International ed.), 2017-01, Vol.56 (1), p.122-126 [Periódico revisado por pares]

Germany: Wiley Subscription Services, Inc

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7
Physiologically‐Based Pharmacokinetic‐Led Guidance for Patients With Cystic Fibrosis Taking Elexacaftor‐Tezacaftor‐Ivacaftor With Nirmatrelvir‐Ritonavir for the Treatment of COVID‐19
Physiologically‐Based Pharmacokinetic‐Led Guidance for Patients With Cystic Fibrosis Taking Elexacaftor‐Tezacaftor‐Ivacaftor With Nirmatrelvir‐Ritonavir for the Treatment of COVID‐19
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Physiologically‐Based Pharmacokinetic‐Led Guidance for Patients With Cystic Fibrosis Taking Elexacaftor‐Tezacaftor‐Ivacaftor With Nirmatrelvir‐Ritonavir for the Treatment of COVID‐19

Hong, Eunjin ; Almond, Lisa M. ; Chung, Peter S. ; Rao, Adupa P. ; Beringer, Paul M.

Clinical pharmacology and therapeutics, 2022-06, Vol.111 (6), p.1324-1333 [Periódico revisado por pares]

United States: John Wiley and Sons Inc

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8
Pharmacokinetic interaction between the hepatitis C virus protease inhibitor boceprevir and cyclosporine and tacrolimus in healthy volunteers
Pharmacokinetic interaction between the hepatitis C virus protease inhibitor boceprevir and cyclosporine and tacrolimus in healthy volunteers
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Pharmacokinetic interaction between the hepatitis C virus protease inhibitor boceprevir and cyclosporine and tacrolimus in healthy volunteers

Hulskotte, Ellen ; Gupta, Samir ; Xuan, Fengjuan ; van Zutven, Marga ; O'Mara, Edward ; Feng, Hwa-Ping ; Wagner, John ; Butterton, Joan

Hepatology (Baltimore, Md.), 2012-11, Vol.56 (5), p.1622-1630 [Periódico revisado por pares]

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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9
Discovery of a Potent (4R,5S)‑4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling
Discovery of a Potent (4R,5S)‑4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling
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Discovery of a Potent (4R,5S)‑4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling

Chen, Huifen ; Volgraf, Matthew ; Do, Steven ; Kolesnikov, Aleksandr ; Shore, Daniel G ; Verma, Vishal A ; Villemure, Elisia ; Wang, Lan ; Chen, Yong ; Hu, Baihua ; Lu, Ai-Jun ; Wu, Guosheng ; Xu, Xiaofeng ; Yuen, Po-wai ; Zhang, Yamin ; Erickson, Shawn D ; Dahl, Martin ; Brotherton-Pleiss, Christine ; Tay, Suzanne ; Ly, Justin Q ; Murray, Lesley J ; Chen, Jun ; Amm, Desiree ; Lange, Wienke ; Hackos, David H ; Reese, Rebecca M ; Shields, Shannon D ; Lyssikatos, Joseph P ; Safina, Brian S ; Estrada, Anthony A

Journal of medicinal chemistry, 2018-04, Vol.61 (8), p.3641-3659 [Periódico revisado por pares]

United States: American Chemical Society

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10
Population Pharmacokinetics of Glecaprevir/Pibrentasvir in HCV‐infected Japanese Subjects in Phase 3 CERTAIN‐1 and CERTAIN‐2 Trials
Population Pharmacokinetics of Glecaprevir/Pibrentasvir in HCV‐infected Japanese Subjects in Phase 3 CERTAIN‐1 and CERTAIN‐2 Trials
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Population Pharmacokinetics of Glecaprevir/Pibrentasvir in HCV‐infected Japanese Subjects in Phase 3 CERTAIN‐1 and CERTAIN‐2 Trials

Suleiman, Ahmed Abbas ; Lin, Chih‐Wei ; Liu, Wei ; Eckert, Doerthe ; Mensing, Sven ; Burroughs, Margaret ; Kato, Koji ; Chayama, Kazuaki ; Kumada, Hiromitsu ; Oberoi, Rajneet K.

Journal of clinical pharmacology, 2020-03, Vol.60 (3), p.331-339 [Periódico revisado por pares]

England: American College of Clinical Pharmacology

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