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Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β‑Arrestin‑2
Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β‑Arrestin‑2
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Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β‑Arrestin‑2

Váradi, András ; Marrone, Gina F ; Palmer, Travis C ; Narayan, Ankita ; Szabó, Márton R ; Le Rouzic, Valerie ; Grinnell, Steven G ; Subrath, Joan J ; Warner, Evelyn ; Kalra, Sanjay ; Hunkele, Amanda ; Pagirsky, Jeremy ; Eans, Shainnel O ; Medina, Jessica M ; Xu, Jin ; Pan, Ying-Xian ; Borics, Attila ; Pasternak, Gavril W ; McLaughlin, Jay P ; Majumdar, Susruta

Journal of medicinal chemistry, 2016-09, Vol.59 (18), p.8381-8397 [Periódico revisado por pares]

United States: American Chemical Society

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2
Insights into distinct signaling profiles of the µOR activated by diverse agonists
Insights into distinct signaling profiles of the µOR activated by diverse agonists
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Insights into distinct signaling profiles of the µOR activated by diverse agonists

Qu, Qianhui ; Huang, Weijiao ; Aydin, Deniz ; Paggi, Joseph M ; Seven, Alpay B ; Wang, Haoqing ; Chakraborty, Soumen ; Che, Tao ; DiBerto, Jeffrey F ; Robertson, Michael J ; Inoue, Asuka ; Suomivuori, Carl-Mikael ; Roth, Bryan L ; Majumdar, Susruta ; Dror, Ron O ; Kobilka, Brian K ; Skiniotis, Georgios

Nature chemical biology, 2023-04, Vol.19 (4), p.423-430 [Periódico revisado por pares]

United States: Nature Publishing Group

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3
Structure-based discovery of opioid analgesics with reduced side effects
Structure-based discovery of opioid analgesics with reduced side effects
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Structure-based discovery of opioid analgesics with reduced side effects

Manglik, Aashish ; Lin, Henry ; Aryal, Dipendra K ; McCorvy, John D ; Dengler, Daniela ; Corder, Gregory ; Levit, Anat ; Kling, Ralf C ; Bernat, Viachaslau ; Hübner, Harald ; Huang, Xi-Ping ; Sassano, Maria F ; Giguère, Patrick M ; Löber, Stefan ; Da Duan ; Scherrer, Grégory ; Kobilka, Brian K ; Gmeiner, Peter ; Roth, Bryan L ; Shoichet, Brian K

Nature (London), 2016-09, Vol.537 (7619), p.185-190 [Periódico revisado por pares]

England: Nature Publishing Group

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4
Abuse-Deterrent Formulations and the Prescription Opioid Abuse Epidemic in the United States: Lessons Learned From OxyContin
Abuse-Deterrent Formulations and the Prescription Opioid Abuse Epidemic in the United States: Lessons Learned From OxyContin
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Abuse-Deterrent Formulations and the Prescription Opioid Abuse Epidemic in the United States: Lessons Learned From OxyContin

Cicero, Theodore J ; Ellis, Matthew S

JAMA psychiatry (Chicago, Ill.), 2015-05, Vol.72 (5), p.424-430 [Periódico revisado por pares]

United States: American Medical Association

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5
Nociceptin Opioid Receptor (NOP) as a Therapeutic Target: Progress in Translation from Preclinical Research to Clinical Utility
Nociceptin Opioid Receptor (NOP) as a Therapeutic Target: Progress in Translation from Preclinical Research to Clinical Utility
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Nociceptin Opioid Receptor (NOP) as a Therapeutic Target: Progress in Translation from Preclinical Research to Clinical Utility

Zaveri, Nurulain T

Journal of medicinal chemistry, 2016-08, Vol.59 (15), p.7011-7028 [Periódico revisado por pares]

United States

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6
The Fentanyl Story
The Fentanyl Story
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The Fentanyl Story

Stanley, Theodore H

The journal of pain, 2014-12, Vol.15 (12), p.1215-1226 [Periódico revisado por pares]

United States: Elsevier Inc

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7
Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D 3 (D 3 R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics
Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D 3 (D 3 R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics
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Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D 3 (D 3 R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics

Bonifazi, Alessandro ; Saab, Elizabeth ; Sanchez, Julie ; Nazarova, Antonina L ; Zaidi, Saheem A ; Jahan, Khorshada ; Katritch, Vsevolod ; Canals, Meritxell ; Lane, J Robert ; Newman, Amy Hauck

Journal of medicinal chemistry, 2023-08, Vol.66 (15), p.10304-10341 [Periódico revisado por pares]

United States

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8
3D printed opioid medicines with alcohol-resistant and abuse-deterrent properties
3D printed opioid medicines with alcohol-resistant and abuse-deterrent properties
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3D printed opioid medicines with alcohol-resistant and abuse-deterrent properties

Ong, Jun Jie ; Awad, Atheer ; Martorana, Annalisa ; Gaisford, Simon ; Stoyanov, Edmont ; Basit, Abdul W. ; Goyanes, Alvaro

International journal of pharmaceutics, 2020-04, Vol.579, p.119169, Article 119169 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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9
Structure-based design of bitopic ligands for the µ-opioid receptor
Structure-based design of bitopic ligands for the µ-opioid receptor
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Structure-based design of bitopic ligands for the µ-opioid receptor

Faouzi, Abdelfattah ; Wang, Haoqing ; Zaidi, Saheem A ; DiBerto, Jeffrey F ; Che, Tao ; Qu, Qianhui ; Robertson, Michael J ; Madasu, Manish K ; El Daibani, Amal ; Varga, Balazs R ; Zhang, Tiffany ; Ruiz, Claudia ; Liu, Shan ; Xu, Jin ; Appourchaux, Kevin ; Slocum, Samuel T ; Eans, Shainnel O ; Cameron, Michael D ; Al-Hasani, Ream ; Pan, Ying Xian ; Roth, Bryan L ; McLaughlin, Jay P ; Skiniotis, Georgios ; Katritch, Vsevolod ; Kobilka, Brian K ; Majumdar, Susruta

Nature (London), 2023-01, Vol.613 (7945), p.767-774 [Periódico revisado por pares]

England: Nature Publishing Group

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10
The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides
The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides
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The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides

Meyrath, Max ; Szpakowska, Martyna ; Zeiner, Julian ; Massotte, Laurent ; Merz, Myriam P ; Benkel, Tobias ; Simon, Katharina ; Ohnmacht, Jochen ; Turner, Jonathan D ; Krüger, Rejko ; Seutin, Vincent ; Ollert, Markus ; Kostenis, Evi ; Chevigné, Andy

Nature communications, 2020-06, Vol.11 (1), p.3033-3033, Article 3033 [Periódico revisado por pares]

England: Nature Publishing Group

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