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Material Type: Artigo
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Presence of benznidazole conjugated metabolites in urine identified by β-glucuronidase treatmentMarson, María Elena; Bournissen, Facundo García; Altcheh, Jaime; Moscatelli, Guillermo; Moroni, Samantha; Mastrantonio, Guido EnriqueBrazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18034Universidade de São Paulo. Faculdade de Ciências Farmacêuticas 2020-12-09Acesso online |
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Material Type: Artigo
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Design and Synthesis of Novel 3-Nitro-1 H -1,2,4-triazole-1,2,3-triazole-1,4-disubstituted Analogs as Promising Antitrypanosomatid Agents: Evaluation of In Vitro Activity against Chagas Disease and LeishmaniasisPelizaro, Bruno I ; Batista, Jaqueline C Z ; Portapilla, Gisele B ; das Neves, Amarith R ; Silva, Fernanda ; Carvalho, Diego B ; Shiguemoto, Cristiane Y K ; Pessatto, Lucas R ; Paredes-Gamero, Edgar J ; Cardoso, Iara A ; Luccas, Pedro H ; Nonato, M Cristina ; Lopes, Norberto P ; Galvão, Fernanda ; Oliveira, Kelly M P ; Cassemiro, Nadla S ; Silva, Denise B ; Piranda, Eliane M ; Arruda, Carla C P ; de Albuquerque, Sergio ; Baroni, Adriano C MJournal of medicinal chemistry, 2024-02, Vol.67 (4), p.2584-2601 [Periódico revisado por pares]United StatesTexto completo disponível |
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Material Type: Artigo
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Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivityZingales, BiancaActa tropica, 2018-08, Vol.184, p.38-52 [Periódico revisado por pares]Netherlands: Elsevier B.VTexto completo disponível |
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Material Type: Artigo
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Anti-trypanosomatid drug discovery: progress and challengesDe Rycker, Manu ; Wyllie, Susan ; Horn, David ; Read, Kevin D ; Gilbert, Ian HNature reviews. Microbiology, 2023-01, Vol.21 (1), p.35-50 [Periódico revisado por pares]England: Nature Publishing GroupTexto completo disponível |
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Material Type: Artigo
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Benznidazole and Posaconazole in Eliminating Parasites in Asymptomatic T. Cruzi Carriers: The STOP-CHAGAS TrialMorillo, Carlos A ; Waskin, Hetty ; Sosa-Estani, Sergio ; Del Carmen Bangher, Maria ; Cuneo, Carlos ; Milesi, Rodolfo ; Mallagray, Marcelo ; Apt, Werner ; Beloscar, Juan ; Gascon, Joaquim ; Molina, Israel ; Echeverria, Luis E ; Colombo, Hugo ; Perez-Molina, Jose Antonio ; Wyss, Fernando ; Meeks, Brandi ; Bonilla, Laura R ; Gao, Peggy ; Wei, Bo ; McCarthy, Michael ; Yusuf, SalimJournal of the American College of Cardiology, 2017-02, Vol.69 (8), p.939-947 [Periódico revisado por pares]United States: Elsevier LimitedTexto completo disponível |
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Material Type: Artigo
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Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas DiseaseEl-Sayed, Najib M ; Myler, Peter J ; Bartholomeu, Daniella C ; Nilsson, Daniel ; Aggarwal, Gautam ; Tran, Anh-Nhi ; Ghedin, Elodie ; Worthey, Elizabeth A ; Delcher, Arthur L ; Blandin, Gae̊lle ; Westenberger, Scott J ; Caler, Elisabet ; Cerqueira, Gustavo C ; Branche, Carole ; Haas, Brian ; Anupama, Atashi ; Arner, Erik ; Åslund, Lena ; Attipoe, Philip ; Bontempi, Esteban ; Bringaud, Frédéric ; Burton, Peter ; Cadag, Eithon ; Campbell, David A ; Carrington, Mark ; Crabtree, Jonathan ; Darban, Hamid ; da Silveira, Jose Franco ; de Jong, Pieter ; Edwards, Kimberly ; Englund, Paul T ; Fazelina, Gholam ; Feldblyum, Tamara ; Ferella, Marcela ; Frasch, Alberto Carlos ; Gull, Keith ; Horn, David ; Hou, Lihua ; Huang, Yiting ; Kindlund, Ellen ; Klingbeil, Michele ; Kluge, Sindy ; Koo, Hean ; Lacerda, Daniela ; Levin, Mariano J ; Lorenzi, Hernan ; Louie, Tin ; Machado, Carlos Renato ; McCulloch, Richard ; McKenna, Alan ; Mizuno, Yumi ; Mottram, Jeremy C ; Nelson, Siri ; Ochaya, Stephen ; Osoegawa, Kazutoyo ; Pai, Grace ; Parsons, Marilyn ; Pentony, Martin ; Pettersson, Ulf ; Pop, Mihai ; Ramirez, Jose Luis ; Rinta, Joel ; Robertson, Laura ; Salzberg, Steven L ; Sanchez, Daniel O ; Seyler, Amber ; Sharma, Reuben ; Shetty, Jyoti ; Simpson, Anjana J ; Sisk, Ellen ; Tammi, Martti T ; Tarleton, Rick ; Teixeira, Santuza ; Van Aken, Susan ; Vogt, Christy ; Ward, Pauline N ; Wickstead, Bill ; Wortman, Jennifer ; White, Owen ; Fraser, Claire M ; Stuart, Kenneth D ; Andersson, BjörnScience (American Association for the Advancement of Science), 2005-07, Vol.309 (5733), p.409-415 [Periódico revisado por pares]United States: American Association for the Advancement of ScienceTexto completo disponível |
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Material Type: Artigo
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A Phase 2, Randomized, Multicenter, Placebo-Controlled, Proof-of-Concept Trial of Oral Fexinidazole in Adults With Chronic Indeterminate Chagas DiseaseTorrico, Faustino ; Gascón, Joaquim ; Ortiz, Lourdes ; Pinto, Jimy ; Rojas, Gimena ; Palacios, Alejandro ; Barreira, Fabiana ; Blum, Bethania ; Schijman, Alejandro Gabriel ; Vaillant, Michel ; Strub-Wourgaft, Nathalie ; Pinazo, Maria-Jesus ; Bilbe, Graeme ; Ribeiro, IsabelaClinical infectious diseases, 2023-02, Vol.76 (3), p.e1186-e1194 [Periódico revisado por pares]United States: Oxford University PressTexto completo disponível |
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Material Type: Artigo
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Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled trialTorrico, Faustino ; Gascon, Joaquim ; Ortiz, Lourdes ; Alonso-Vega, Cristina ; Pinazo, María-Jesús ; Schijman, Alejandro ; Almeida, Igor C ; Alves, Fabiana ; Strub-Wourgaft, Nathalie ; Ribeiro, Isabela ; Santina, Glaucia ; Blum, Bethania ; Correia, Erika ; Garcia-Bournisen, Facundo ; Vaillant, Michel ; Morales, Jimena Ramos ; Pinto Rocha, Jimy Jose ; Rojas Delgadillo, Gimena ; Magne Anzoleaga, Helmut Ramon ; Mendoza, Nilce ; Quechover, Roxana Challapa ; Caballero, Maria Yurly Escobar ; Lozano Beltran, Daniel Franz ; Zalabar, Albert Mendoza ; Rojas Panozo, Lizeth ; Palacios Lopez, Alejandro ; Torrico Terceros, Dunia ; Fernandez Galvez, Violeta Alejandra ; Cardozo, Letty ; Cuellar, Gabriela ; Vasco Arenas, Rudy Nelson ; Gonzales, Isabel ; Hoyos Delfin, Carlos Florencio ; Garcia, Lineth ; Parrado, Rudy ; de la Barra, Anabelle ; Montano, Nair ; Villarroel, Sandro ; Duffy, Tomas ; Bisio, Margarita ; Ramirez, Juan Carlos ; Duncanson, Fred ; Everson, Michael ; Daniels, Antonia ; Asada, Makoto ; Cox, Eugene ; Wesche, David ; Diderichsen, Paul Matthias ; Marques, Alexandre F ; Izquierdo, Luis ; Sender, Silvia Sanz ; Reverter, Joan Carlos ; Morales, Manuel ; Jimenez, WladimiroThe Lancet infectious diseases, 2018-04, Vol.18 (4), p.419-430 [Periódico revisado por pares]United States: Elsevier LtdTexto completo disponível |
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Material Type: Artigo
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Experimental and Clinical Treatment of Chagas Disease: A ReviewSales Junior, Policarpo Ademar ; Molina, Israel ; Fonseca Murta, Silvane Maria ; Sánchez-Montalvá, Adrián ; Salvador, Fernando ; Corrêa-Oliveira, Rodrigo ; Carneiro, Cláudia MartinsThe American journal of tropical medicine and hygiene, 2017-11, Vol.97 (5), p.1289-1303 [Periódico revisado por pares]United States: The American Society of Tropical Medicine and HygieneTexto completo disponível |
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Material Type: Artigo
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Drug discovery for chagas disease: A viewpointKratz, Jadel MüllerActa tropica, 2019-10, Vol.198, p.105107-105107, Article 105107 [Periódico revisado por pares]Netherlands: Elsevier B.VTexto completo disponível |