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1 |
Material Type: Artigo
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Prioritization of cancer therapeutic targets using CRISPR-Cas9 screensBehan, Fiona M ; Iorio, Francesco ; Picco, Gabriele ; Gonçalves, Emanuel ; Beaver, Charlotte M ; Migliardi, Giorgia ; Santos, Rita ; Rao, Yanhua ; Sassi, Francesco ; Pinnelli, Marika ; Ansari, Rizwan ; Harper, Sarah ; Jackson, David Adam ; McRae, Rebecca ; Pooley, Rachel ; Wilkinson, Piers ; van der Meer, Dieudonne ; Dow, David ; Buser-Doepner, Carolyn ; Bertotti, Andrea ; Trusolino, Livio ; Stronach, Euan A ; Saez-Rodriguez, Julio ; Yusa, Kosuke ; Garnett, Mathew JNature (London), 2019-04, Vol.568 (7753), p.511-516 [Periódico revisado por pares]England: Nature Publishing GroupTexto completo disponível |
2 |
Material Type: Artigo
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Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screeningPicco, Gabriele ; Chen, Elisabeth D ; Alonso, Luz Garcia ; Behan, Fiona M ; Gonçalves, Emanuel ; Bignell, Graham ; Matchan, Angela ; Fu, Beiyuan ; Banerjee, Ruby ; Anderson, Elizabeth ; Butler, Adam ; Benes, Cyril H ; McDermott, Ultan ; Dow, David ; Iorio, Francesco ; Stronach, Euan ; Yang, Fengtang ; Yusa, Kosuke ; Saez-Rodriguez, Julio ; Garnett, Mathew JNature communications, 2019-05, Vol.10 (1), p.2198-12, Article 2198 [Periódico revisado por pares]England: Nature Publishing GroupTexto completo disponível |
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Material Type: Artigo
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Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancerBowtell, David D ; Böhm, Steffen ; Ahmed, Ahmed A ; Aspuria, Paul-Joseph ; Bast, Jr, Robert C ; Beral, Valerie ; Berek, Jonathan S ; Birrer, Michael J ; Blagden, Sarah ; Bookman, Michael A ; Brenton, James D ; Chiappinelli, Katherine B ; Martins, Filipe Correia ; Coukos, George ; Drapkin, Ronny ; Edmondson, Richard ; Fotopoulou, Christina ; Gabra, Hani ; Galon, Jérôme ; Gourley, Charlie ; Heong, Valerie ; Huntsman, David G ; Iwanicki, Marcin ; Karlan, Beth Y ; Kaye, Allyson ; Lengyel, Ernst ; Levine, Douglas A ; Lu, Karen H ; McNeish, Iain A ; Menon, Usha ; Narod, Steven A ; Nelson, Brad H ; Nephew, Kenneth P ; Pharoah, Paul ; Powell, Jr, Daniel J ; Ramos, Pilar ; Romero, Iris L ; Scott, Clare L ; Sood, Anil K ; Stronach, Euan A ; Balkwill, Frances RNature reviews. Cancer, 2015-11, Vol.15 (11), p.668-679 [Periódico revisado por pares]England: Nature Publishing GroupTexto completo disponível |
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Material Type: Artigo
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Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effectsGonçalves, Emanuel ; Behan, Fiona M ; Louzada, Sandra ; Arnol, Damien ; Stronach, Euan A ; Yang, Fengtang ; Yusa, Kosuke ; Stegle, Oliver ; Iorio, Francesco ; Garnett, Mathew JGenome Biology, 2019-02, Vol.20 (1), p.27-10, Article 27 [Periódico revisado por pares]England: BioMed CentralTexto completo disponível |
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Material Type: Artigo
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Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targetingIorio, Francesco ; Behan, Fiona M ; Gonçalves, Emanuel ; Bhosle, Shriram G ; Chen, Elisabeth ; Shepherd, Rebecca ; Beaver, Charlotte ; Ansari, Rizwan ; Pooley, Rachel ; Wilkinson, Piers ; Harper, Sarah ; Butler, Adam P ; Stronach, Euan A ; Saez-Rodriguez, Julio ; Yusa, Kosuke ; Garnett, Mathew JBMC genomics, 2018-08, Vol.19 (1), p.604-604, Article 604 [Periódico revisado por pares]England: BioMed Central LtdTexto completo disponível |
6 |
Material Type: Artigo
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Biomarker Assessment of HR Deficiency, Tumor BRCA1/2 Mutations, and CCNE1 Copy Number in Ovarian Cancer: Associations with Clinical Outcome Following Platinum MonotherapyStronach, Euan A ; Paul, James ; Timms, Kirsten M ; Hughes, Elisha ; Brown, Krystal ; Neff, Christopher ; Perry, Michael ; Gutin, Alexander ; El-Bahrawy, Mona ; Steel, Jennifer H ; Liu, Xinxue ; Lewsley, Liz-Anne ; Siddiqui, Nadeem ; Gabra, Hani ; Lanchbury, Jerry S ; Brown, RobertMolecular cancer research, 2018-07, Vol.16 (7), p.1103-1111 [Periódico revisado por pares]United States: American Association for Cancer Research IncTexto completo disponível |
7 |
Material Type: Artigo
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DNA-PK Mediates AKT Activation and Apoptosis Inhibition in Clinically Acquired Platinum ResistanceStronach, Euan A ; Chen, Michelle ; Maginn, Elaina N ; Agarwal, Roshan ; Mills, Gordon B ; Wasan, Harpreet ; Gabra, HaniNeoplasia (New York, N.Y.), 2011-11, Vol.13 (11), p.1069-IN35 [Periódico revisado por pares]United States: Elsevier IncTexto completo disponível |
8 |
Material Type: Artigo
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Dietary geranylgeraniol can limit the activity of pitavastatin as a potential treatment for drug-resistant ovarian cancerde Wolf, Elizabeth ; Abdullah, Marwan Ibrahim ; Jones, Stefanie M ; Menezes, Karen ; Moss, Darren M ; Drijfhout, Falko P ; Hart, Sarah R ; Hoskins, Clare ; Stronach, Euan A ; Richardson, AlanScientific reports, 2017-07, Vol.7 (1), p.5410-10, Article 5410 [Periódico revisado por pares]England: Nature Publishing GroupTexto completo disponível |
9 |
Material Type: Artigo
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Phase IB Dose Escalation and Expansion Study of AKT Inhibitor Afuresertib with Carboplatin and Paclitaxel in Recurrent Platinum-resistant Ovarian CancerBlagden, Sarah P ; Hamilton, Anne L ; Mileshkin, Linda ; Wong, Shirley ; Michael, Agnieszka ; Hall, Marcia ; Goh, Jeffrey C ; Lisyanskaya, Alla S ; DeSilvio, Michelle ; Frangou, Eleni ; Stronach, Euan A ; Gopalakrishna, Prashanth ; Meniawy, Tarek M ; Gabra, HaniClinical cancer research, 2019-03, Vol.25 (5), p.1472-1478 [Periódico revisado por pares]United StatesTexto completo disponível |
10 |
Material Type: Artigo
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HDAC4-Regulated STAT1 Activation Mediates Platinum Resistance in Ovarian CancerSTRONACH, Euan A ; ALFRAIDI, Albandri ; MAI, Antonello ; BROWN, Robert ; DINA, Roberto ; GABRA, Hani ; RAMA, Nona ; DATLER, Christoph ; STUDD, James B ; AGARWAL, Roshan ; GUNEY, Tankut G ; GOURLEY, Charlie ; HENNESSY, Bryan T ; MILLS, Gordon BCancer research (Chicago, Ill.), 2011-07, Vol.71 (13), p.4412-4422 [Periódico revisado por pares]Philadelphia, PA: American Association for Cancer ResearchTexto completo disponível |