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Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patientsWoolbright, Benjamin L ; McGill, Mitchell R ; Staggs, Vincent S ; Winefield, Robert D ; Gholami, Parviz ; Olyaee, Mojtaba ; Sharpe, Matthew R ; Curry, Steven C ; Lee, William M ; Jaeschke, HartmutToxicological sciences, 2014-12, Vol.142 (2), p.436-444 [Periódico revisado por pares]United States: Oxford University PressTexto completo disponível |
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Modulation of O-GlcNAc Levels in the Liver Impacts Acetaminophen-Induced Liver Injury by Affecting Protein Adduct Formation and Glutathione SynthesisMcGreal, Steven R ; Bhushan, Bharat ; Walesky, Chad ; McGill, Mitchell R ; Lebofsky, Margitta ; Kandel, Sylvie E ; Winefield, Robert D ; Jaeschke, Hartmut ; Zachara, Natasha E ; Zhang, Zhen ; Tan, Ee Phie ; Slawson, Chad ; Apte, UdayanToxicological sciences, 2018-04, Vol.162 (2), p.599-610 [Periódico revisado por pares]United States: Oxford University PressTexto completo disponível |
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Possible Role of Extracellular Vesicles in Hepatotoxicity of AcetaminophenŠrajer Gajdošik, Martina ; Kovač Peić, Anamarija ; Begić, Marija ; Grbčić, Petra ; Brilliant, Kate E ; Hixson, Douglas C ; Josić, DjuroInternational journal of molecular sciences, 2022-08, Vol.23 (16), p.8870 [Periódico revisado por pares]Switzerland: MDPI AGTexto completo disponível |
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The acetaminophen metabolite N-acetyl-p-benzoquinone imine (NAPQI) inhibits glutathione synthetase in vitro; a clue to the mechanism of 5-oxoprolinuric acidosis?Walker, Valerie ; Mills, Graham A. ; Anderson, Mary E. ; Ingle, Brandall L. ; Jackson, John M. ; Moss, Charlotte L. ; Sharrod-Cole, Hayley ; Skipp, Paul J.Xenobiotica, 2017-02, Vol.47 (2), p.164-175 [Periódico revisado por pares]England: Taylor & FrancisTexto completo disponível |
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The protective effects of carvacrol and thymol against paracetamol–induced toxicity on human hepatocellular carcinoma cell lines (HepG2)Palabiyik, SS ; Karakus, E ; Halici, Z ; Cadirci, E ; Bayir, Y ; Ayaz, G ; Cinar, IHuman & experimental toxicology, 2016-12, Vol.35 (12), p.1252-1263 [Periódico revisado por pares]London, England: SAGE PublicationsTexto completo disponível |
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Loss of Nrf2 in mice evokes a congenital intrahepatic shunt that alters hepatic oxygen and protein expression gradients and toxicitySkoko, John J ; Wakabayashi, Nobunao ; Noda, Kentaro ; Kimura, Shoko ; Tobita, Kimimasa ; Shigemura, Norihisa ; Tsujita, Tadayuki ; Yamamoto, Masayuki ; Kensler, Thomas WToxicological sciences, 2014-09, Vol.141 (1), p.112-119 [Periódico revisado por pares]United States: Oxford University PressTexto completo disponível |
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Material Type: Artigo
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Glutathione metabolism modeling: A mechanism for liver drug-robustness and a new biomarker strategyGeenen, Suzanne ; du Preez, Franco B. ; Snoep, Jacky L. ; Foster, Alison J. ; Sarda, Sunil ; Kenna, J. Gerry ; Wilson, Ian D. ; Westerhoff, Hans V.Biochimica et biophysica acta. General subjects, 2013-10, Vol.1830 (10), p.4943-4959 [Periódico revisado por pares]Elsevier B.VTexto completo disponível |
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Bortezomib alleviates drug-induced liver injury by regulating CYP2E1 gene transcriptionPARK, WOO-JAE ; KIM, SO-YEON ; KIM, YE-RYUNG ; PARK, JOO-WONInternational journal of molecular medicine, 2016-03, Vol.37 (3), p.613-622 [Periódico revisado por pares]Athens: D.A. SpandidosTexto completo disponível |
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PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injuryNorth, Trista E. ; Babu, I. Ramesh ; Vedder, Lea M. ; Lord, Allegra M. ; Wishnok, John S. ; Tannenbaum, Steven R. ; Zon, Leonard I. ; Goessling, WolframProceedings of the National Academy of Sciences - PNAS, 2010-10, Vol.107 (40), p.17315-17320 [Periódico revisado por pares]United States: National Academy of SciencesTexto completo disponível |
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Material Type: Artigo
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Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in MiceBhushan, Bharat ; Chavan, Hemantkumar ; Borude, Prachi ; Xie, Yuchao ; Du, Kuo ; McGill, Mitchell R ; Lebofsky, Margitta ; Jaeschke, Hartmut ; Krishnamurthy, Partha ; Apte, UdayanToxicological sciences, 2017-02, Vol.155 (2), p.363-378 [Periódico revisado por pares]United States: Oxford University PressTexto completo disponível |