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From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity
From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity
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From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity

Abdel-Halim, Mohammad ; Sigler, Sara ; Racheed, Nora A. S ; Hefnawy, Amr ; Fathalla, Reem K ; Hammam, Mennatallah A ; Maher, Ahmed ; Maxuitenko, Yulia ; Keeton, Adam B ; Hartmann, Rolf W ; Engel, Matthias ; Piazza, Gary A ; Abadi, Ashraf H

Journal of medicinal chemistry, 2021-04, Vol.64 (8), p.4462-4477 [Periódico revisado por pares]

United States: American Chemical Society

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2
Phosphodiesterase Type 5: Expanding Roles in Cardiovascular Regulation
Phosphodiesterase Type 5: Expanding Roles in Cardiovascular Regulation
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Phosphodiesterase Type 5: Expanding Roles in Cardiovascular Regulation

Kass, David A ; Champion, Hunter C ; Beavo, Joseph A

Circulation research, 2007-11, Vol.101 (11), p.1084-1095 [Periódico revisado por pares]

Hagerstown, MD: American Heart Association, Inc

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3
Ventricular Phosphodiesterase-5 Expression Is Increased in Patients With Advanced Heart Failure and Contributes to Adverse Ventricular Remodeling After Myocardial Infarction in Mice
Ventricular Phosphodiesterase-5 Expression Is Increased in Patients With Advanced Heart Failure and Contributes to Adverse Ventricular Remodeling After Myocardial Infarction in Mice
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Ventricular Phosphodiesterase-5 Expression Is Increased in Patients With Advanced Heart Failure and Contributes to Adverse Ventricular Remodeling After Myocardial Infarction in Mice

POKREISZ, Peter ; VANDENWIJNGAERT, Sara ; XIAOSHUN LIU ; GILLIJNS, Hilde ; PELLENS, Marijke ; VAN LOMMEL, Alfons ; BUYS, Emmanuel ; SCHOONJANS, Luc ; VANHAECKE, Johan ; VERBEKEN, Erik ; SIPIDO, Karin ; HERIJGERS, Paul ; BITO, Virginie ; BLOCH, Kenneth D ; JANSSENS, Stefan P ; VAN DEN BERGH, An ; LENAERTS, Ilse ; BUSCH, Cornelius ; MARSBOOM, Glenn ; GHEYSENS, Olivier ; VERMEERSCH, Pieter ; BIESMANS, Liesbeth

Circulation (New York, N.Y.), 2009-01, Vol.119 (3), p.408-416 [Periódico revisado por pares]

Hagerstown, MD: Lippincott Williams & Wilkins

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4
Structural Determination, Biological Function, and Molecular Modelling Studies of Sulfoaildenafil Adulterated in Herbal Dietary Supplement
Structural Determination, Biological Function, and Molecular Modelling Studies of Sulfoaildenafil Adulterated in Herbal Dietary Supplement
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Structural Determination, Biological Function, and Molecular Modelling Studies of Sulfoaildenafil Adulterated in Herbal Dietary Supplement

Kodchakorn, Kanchanok ; Viriyakhasem, Nawarat ; Wongwichai, Tunchanok ; Kongtawelert, Prachya

Molecules (Basel, Switzerland), 2021-02, Vol.26 (4), p.949 [Periódico revisado por pares]

Switzerland: MDPI AG

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5
Sulfhydration-associated phosphodiesterase 5A dimerization mediates vasorelaxant effect of hydrogen sulfide
Sulfhydration-associated phosphodiesterase 5A dimerization mediates vasorelaxant effect of hydrogen sulfide
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Sulfhydration-associated phosphodiesterase 5A dimerization mediates vasorelaxant effect of hydrogen sulfide

Sun, Yan ; Huang, Yaqian ; Yu, Wen ; Chen, Siyao ; Yao, Qiuyu ; Zhang, Chunyu ; Bu, Dingfang ; Tang, Chaoshu ; Du, Junbao ; Jin, Hongfang

Oncotarget, 2017-05, Vol.8 (19), p.31888-31900

United States: Impact Journals LLC

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6
Q817G mutation in phosphodiesterase type 5: Conformational analysis and dissociation profile of the inhibitor Tadalafil
Q817G mutation in phosphodiesterase type 5: Conformational analysis and dissociation profile of the inhibitor Tadalafil
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Q817G mutation in phosphodiesterase type 5: Conformational analysis and dissociation profile of the inhibitor Tadalafil

Pires de Oliveira, Ivan ; Lescano, Caroline Honaiser ; De Nucci, Gilberto

Chemical biology & drug design, 2019-04, Vol.93 (4), p.419-429 [Periódico revisado por pares]

England

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7
The NO/cGMP/PKG pathway in platelets: The therapeutic potential of PDE5 inhibitors in platelet disorders
The NO/cGMP/PKG pathway in platelets: The therapeutic potential of PDE5 inhibitors in platelet disorders
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The NO/cGMP/PKG pathway in platelets: The therapeutic potential of PDE5 inhibitors in platelet disorders

Degjoni, Anisa ; Campolo, Federica ; Stefanini, Lucia ; Venneri, Mary Anna

Journal of thrombosis and haemostasis, 2022-11, Vol.20 (11), p.2465-2474 [Periódico revisado por pares]

England: Wiley Subscription Services, Inc

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8
Cloning, expression, and characterization of Schistosoma japonicum tegument protein phosphodiesterase-5
Cloning, expression, and characterization of Schistosoma japonicum tegument protein phosphodiesterase-5
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Cloning, expression, and characterization of Schistosoma japonicum tegument protein phosphodiesterase-5

Zhang, Min ; Han, Yanhui ; Zhu, Zhu ; Li, Dong ; Hong, Yang ; Wu, Xiujuan ; Fu, Zhiqiang ; Lin, Jiaojiao

Parasitology research (1987), 2012-02, Vol.110 (2), p.775-786 [Periódico revisado por pares]

Berlin/Heidelberg: Springer-Verlag

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9
Phosphodiesterase 5 (PDE5): Structure-function regulation and therapeutic applications of inhibitors
Phosphodiesterase 5 (PDE5): Structure-function regulation and therapeutic applications of inhibitors
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Phosphodiesterase 5 (PDE5): Structure-function regulation and therapeutic applications of inhibitors

Ahmed, Wesam S. ; Geethakumari, Anupriya M. ; Biswas, Kabir H.

Biomedicine & pharmacotherapy, 2021-02, Vol.134, p.111128, Article 111128 [Periódico revisado por pares]

France: Elsevier Masson SAS

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10
Characterization of Conformational Changes and Protein-Protein Interactions of Rod Photoreceptor Phosphodiesterase (PDE6)
Characterization of Conformational Changes and Protein-Protein Interactions of Rod Photoreceptor Phosphodiesterase (PDE6)
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Characterization of Conformational Changes and Protein-Protein Interactions of Rod Photoreceptor Phosphodiesterase (PDE6)

Matte, Suzanne L. ; Laue, Thomas M. ; Cote, Rick H.

The Journal of biological chemistry, 2012-06, Vol.287 (24), p.20111-20121 [Periódico revisado por pares]

United States: Elsevier Inc

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