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The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches
The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches
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The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches

Joerger, Andreas C ; Fersht, Alan R

Annual review of biochemistry, 2016-06, Vol.85 (1), p.375-404 [Periódico revisado por pares]

United States: Annual Reviews

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2
Targeting p53 for the treatment of cancer
Targeting p53 for the treatment of cancer
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Targeting p53 for the treatment of cancer

Duffy, Michael J. ; Synnott, Naoise C. ; O’Grady, Shane ; Crown, John

Seminars in cancer biology, 2022-02, Vol.79, p.58-67 [Periódico revisado por pares]

England: Elsevier Ltd

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3
MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling
MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling
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MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling

Venkatesh, Divya ; O'Brien, Nicholas A ; Zandkarimi, Fereshteh ; Tong, David R ; Stokes, Michael E ; Dunn, Denise E ; Kengmana, Everett S ; Aron, Allegra T ; Klein, Alyssa M ; Csuka, Joleen M ; Moon, Sung-Hwan ; Conrad, Marcus ; Chang, Christopher J ; Lo, Donald C ; D'Alessandro, Angelo ; Prives, Carol ; Stockwell, Brent R

Genes & development, 2020-04, Vol.34 (7-8), p.526-543 [Periódico revisado por pares]

United States: Cold Spring Harbor Laboratory Press

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4
Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment
Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment
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Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment

Zhao, Yujun ; Aguilar, Angelo ; Bernard, Denzil ; Wang, Shaomeng

Journal of medicinal chemistry, 2015-02, Vol.58 (3), p.1038-1052 [Periódico revisado por pares]

United States

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5
Results of the Phase I Trial of RG7112, a Small-Molecule MDM2 Antagonist in Leukemia
Results of the Phase I Trial of RG7112, a Small-Molecule MDM2 Antagonist in Leukemia
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Results of the Phase I Trial of RG7112, a Small-Molecule MDM2 Antagonist in Leukemia

Andreeff, Michael ; Kelly, Kevin R ; Yee, Karen ; Assouline, Sarit ; Strair, Roger ; Popplewell, Leslie ; Bowen, David ; Martinelli, Giovanni ; Drummond, Mark W ; Vyas, Paresh ; Kirschbaum, Mark ; Iyer, Swaminathan Padmanabhan ; Ruvolo, Vivian ; González, Graciela M Nogueras ; Huang, Xuelin ; Chen, Gong ; Graves, Bradford ; Blotner, Steven ; Bridge, Peter ; Jukofsky, Lori ; Middleton, Steve ; Reckner, Monica ; Rueger, Ruediger ; Zhi, Jianguo ; Nichols, Gwen ; Kojima, Kensuke

Clinical cancer research, 2016-02, Vol.22 (4), p.868-876 [Periódico revisado por pares]

United States

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6
MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer
MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer
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MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer

Tisato, Veronica ; Voltan, Rebecca ; Gonelli, Arianna ; Secchiero, Paola ; Zauli, Giorgio

Journal of hematology and oncology, 2017-07, Vol.10 (1), p.133-133, Article 133 [Periódico revisado por pares]

England: BioMed Central Ltd

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7
Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models
Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models
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Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models

Ng, Samuel Y ; Yoshida, Noriaki ; Christie, Amanda L ; Ghandi, Mahmoud ; Dharia, Neekesh V ; Dempster, Joshua ; Murakami, Mark ; Shigemori, Kay ; Morrow, Sara N ; Van Scoyk, Alexandria ; Cordero, Nicolas A ; Stevenson, Kristen E ; Puligandla, Maneka ; Haas, Brian ; Lo, Christopher ; Meyers, Robin ; Gao, Galen ; Cherniack, Andrew ; Louissaint, Jr, Abner ; Nardi, Valentina ; Thorner, Aaron R ; Long, Henry ; Qiu, Xintao ; Morgan, Elizabeth A ; Dorfman, David M ; Fiore, Danilo ; Jang, Julie ; Epstein, Alan L ; Dogan, Ahmet ; Zhang, Yanming ; Horwitz, Steven M ; Jacobsen, Eric D ; Santiago, Solimar ; Ren, Jian-Guo ; Guerlavais, Vincent ; Annis, D Allen ; Aivado, Manuel ; Saleh, Mansoor N ; Mehta, Amitkumar ; Tsherniak, Aviad ; Root, David ; Vazquez, Francisca ; Hahn, William C ; Inghirami, Giorgio ; Aster, Jon C ; Weinstock, David M ; Koch, Raphael

Nature communications, 2018-05, Vol.9 (1), p.2024-11, Article 2024 [Periódico revisado por pares]

England: Nature Publishing Group

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8
MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors
MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors
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MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors

Howard, Thomas P ; Arnoff, Taylor E ; Song, Melinda R ; Giacomelli, Andrew O ; Wang, Xiaofeng ; Hong, Andrew L ; Dharia, Neekesh V ; Wang, Su ; Vazquez, Francisca ; Pham, Minh-Tam ; Morgan, Ann M ; Wachter, Franziska ; Bird, Gregory H ; Kugener, Guillaume ; Oberlick, Elaine M ; Rees, Matthew G ; Tiv, Hong L ; Hwang, Justin H ; Walsh, Katherine H ; Cook, April ; Krill-Burger, John M ; Tsherniak, Aviad ; Gokhale, Prafulla C ; Park, Peter J ; Stegmaier, Kimberly ; Walensky, Loren D ; Hahn, William C ; Roberts, Charles W M

Cancer research (Chicago, Ill.), 2019-05, Vol.79 (9), p.2404-2414 [Periódico revisado por pares]

United States

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9
The role of p53 in cancer drug resistance and targeted chemotherapy
The role of p53 in cancer drug resistance and targeted chemotherapy
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The role of p53 in cancer drug resistance and targeted chemotherapy

Hientz, Karin ; Mohr, André ; Bhakta-Guha, Dipita ; Efferth, Thomas

Oncotarget, 2017-01, Vol.8 (5), p.8921-8946

United States: Impact Journals LLC

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10
Dual inhibition of MDM2 and MDM4 in virus-positive Merkel cell carcinoma enhances the p53 response
Dual inhibition of MDM2 and MDM4 in virus-positive Merkel cell carcinoma enhances the p53 response
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Dual inhibition of MDM2 and MDM4 in virus-positive Merkel cell carcinoma enhances the p53 response

Park, Donglim Esther ; Cheng, Jingwei ; Berrios, Christian ; Montero, Joan ; Cortés-Cros, Marta ; Ferretti, Stéphane ; Arora, Reety ; Tillgren, Michelle L. ; Gokhale, Prafulla C. ; DeCaprio, James A.

Proceedings of the National Academy of Sciences - PNAS, 2019-01, Vol.116 (3), p.1027-1032 [Periódico revisado por pares]

United States: National Academy of Sciences

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