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PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
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PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer

Glaviano, Antonino ; Foo, Aaron S. C ; Lam, Hiu Y ; Yap, Kenneth C. H ; Jacot, William ; Jones, Robert H ; Eng, Huiyan ; Nair, Madhumathy G ; Makvandi, Pooyan ; Geoerger, Birgit ; Kulke, Matthew H ; Baird, Richard D ; Prabhu, Jyothi S ; Carbone, Daniela ; Pecoraro, Camilla ; Teh, Daniel B. L ; Sethi, Gautam ; Cavalieri, Vincenzo ; Lin, Kevin H ; Javidi-Sharifi, Nathalie R ; Toska, Eneda ; Davids, Matthew S ; Brown, Jennifer R ; Diana, Patrizia ; Stebbing, Justin ; Fruman, David A ; Kumar, Alan P

Molecular cancer, 2023-08, Vol.22 (1), p.1-138, Article 138 [Periódico revisado por pares]

London: BioMed Central Ltd

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Current treatment strategies for inhibiting mTOR in cancer
Current treatment strategies for inhibiting mTOR in cancer
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Current treatment strategies for inhibiting mTOR in cancer

Chiarini, Francesca ; Evangelisti, Camilla ; McCubrey, James A ; Martelli, Alberto M

Trends in pharmacological sciences (Regular ed.), 2015-02, Vol.36 (2), p.124-135 [Periódico revisado por pares]

England: Elsevier Ltd

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3
Contemporary mTOR inhibitor scaffolds to diseases breakdown: A patent review (2015–2021)
Contemporary mTOR inhibitor scaffolds to diseases breakdown: A patent review (2015–2021)
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Contemporary mTOR inhibitor scaffolds to diseases breakdown: A patent review (2015–2021)

Oleksak, Patrik ; Nepovimova, Eugenie ; Chrienova, Zofia ; Musilek, Kamil ; Patocka, Jiri ; Kuca, Kamil

European journal of medicinal chemistry, 2022-08, Vol.238, p.114498-114498, Article 114498 [Periódico revisado por pares]

France: Elsevier Masson SAS

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4
VS-5584, a PI3K/mTOR dual inhibitor, exerts antitumor effects on neuroblastomas in vitro and in vivo
VS-5584, a PI3K/mTOR dual inhibitor, exerts antitumor effects on neuroblastomas in vitro and in vivo
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VS-5584, a PI3K/mTOR dual inhibitor, exerts antitumor effects on neuroblastomas in vitro and in vivo

Chen, Yun ; Tsai, Huang-Wen ; Tsai, Ya-Hui ; Tseng, Sheng-Hong

Journal of pediatric surgery, 2021-08, Vol.56 (8), p.1441-1448 [Periódico revisado por pares]

Elsevier Inc

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5
Function-oriented synthesis of Imidazo[1,2-a]pyrazine and Imidazo[1,2-b]pyridazine derivatives as potent PI3K/mTOR dual inhibitors
Function-oriented synthesis of Imidazo[1,2-a]pyrazine and Imidazo[1,2-b]pyridazine derivatives as potent PI3K/mTOR dual inhibitors
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Function-oriented synthesis of Imidazo[1,2-a]pyrazine and Imidazo[1,2-b]pyridazine derivatives as potent PI3K/mTOR dual inhibitors

Li, Chuchu ; Han, Yuqiao ; Wang, Zhengyang ; Yu, Yanan ; Wang, Chen ; Ren, Ziwei ; Guo, Yanzhi ; Zhu, Tong ; Li, XuWen ; Dong, Suzhen ; Ma, Mingliang

European journal of medicinal chemistry, 2023-02, Vol.247, p.115030, Article 115030 [Periódico revisado por pares]

France: Elsevier Masson SAS

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6
Omipalisib inspired macrocycles as dual PI3K/mTOR inhibitors
Omipalisib inspired macrocycles as dual PI3K/mTOR inhibitors
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Omipalisib inspired macrocycles as dual PI3K/mTOR inhibitors

Álvarez, Rosa M. ; García, Ana Belén ; Riesco-Fagundo, Concepción ; Martín, José I. ; Varela, Carmen ; Rodríguez Hergueta, Antonio ; González Cantalapiedra, Esther ; Oyarzabal, Julen ; Di Geronimo, Bruno ; Lorenzo, Milagros ; Albarrán, M Isabel ; Cebriá, Antonio ; Cebrián, David ; Martínez-González, Sonia ; Blanco-Aparicio, Carmen ; Pastor, Joaquín

European journal of medicinal chemistry, 2021-02, Vol.211, p.113109-113109, Article 113109 [Periódico revisado por pares]

France: Elsevier Masson SAS

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7
Activation of WNT/β‐catenin signaling results in resistance to a dual PI3K/mTOR inhibitor in colorectal cancer cells harboring PIK3CA mutations
Activation of WNT/β‐catenin signaling results in resistance to a dual PI3K/mTOR inhibitor in colorectal cancer cells harboring PIK3CA mutations
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Activation of WNT/β‐catenin signaling results in resistance to a dual PI3K/mTOR inhibitor in colorectal cancer cells harboring PIK3CA mutations

Park, Ye‐Lim ; Kim, Hwang‐Phill ; Cho, Young‐Won ; Min, Dong‐Wook ; Cheon, Seul‐Ki ; Lim, Yoo Joo ; Song, Sang‐Hyun ; Kim, Sung Jin ; Han, Sae‐Won ; Park, Kyu Joo ; Kim, Tae‐You

International journal of cancer, 2019-01, Vol.144 (2), p.389-401 [Periódico revisado por pares]

Hoboken, USA: John Wiley & Sons, Inc

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8
Phase 2 study of LY3023414 in patients with advanced endometrial cancer harboring activating mutations in the PI3K pathway
Phase 2 study of LY3023414 in patients with advanced endometrial cancer harboring activating mutations in the PI3K pathway
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Phase 2 study of LY3023414 in patients with advanced endometrial cancer harboring activating mutations in the PI3K pathway

Rubinstein, Maria M. ; Hyman, David M. ; Caird, Imogen ; Won, Helen ; Soldan, Krysten ; Seier, Kenneth ; Iasonos, Alexia ; Tew, William P. ; O’Cearbhaill, Roisin E. ; Grisham, Rachel N. ; Hensley, Martee L. ; Troso‐Sandoval, Tiffany ; Sabbatini, Paul ; Guillen, Joyce ; Selcuklu, S. Duygu ; Zimel, Catherine ; Torrisi, Jean ; Aghajanian, Carol ; Makker, Vicky

Cancer, 2020-03, Vol.126 (6), p.1274-1282 [Periódico revisado por pares]

United States: Wiley Subscription Services, Inc

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9
A novel PI3K/mTOR dual inhibitor, CMG002, overcomes the chemoresistance in ovarian cancer
A novel PI3K/mTOR dual inhibitor, CMG002, overcomes the chemoresistance in ovarian cancer
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A novel PI3K/mTOR dual inhibitor, CMG002, overcomes the chemoresistance in ovarian cancer

Choi, Hye Joung ; Heo, Jin Hyung ; Park, Ju Yeon ; Jeong, Ju Yeon ; Cho, Hyeon Ju ; Park, Kyung Soon ; Kim, Se Hwa ; Moon, Yong Wha ; Kim, Jin Sung ; An, Hee Jung

Gynecologic oncology, 2019-04, Vol.153 (1), p.135-148 [Periódico revisado por pares]

United States: Elsevier Inc

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10
Discovery of N-(2-chloro-5-(3-(pyridin-4-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide (FD274) as a highly potent PI3K/mTOR dual inhibitor for the treatment of acute myeloid leukemia
Discovery of N-(2-chloro-5-(3-(pyridin-4-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide (FD274) as a highly potent PI3K/mTOR dual inhibitor for the treatment of acute myeloid leukemia
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Discovery of N-(2-chloro-5-(3-(pyridin-4-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide (FD274) as a highly potent PI3K/mTOR dual inhibitor for the treatment of acute myeloid leukemia

Yang, Chengbin ; Chen, Yi ; Wu, Tianze ; Gao, Yunjian ; Liu, Xiaofeng ; Yang, Yongtai ; Ling, Yun ; Jia, Yu ; Deng, Mingli ; Wang, Jianxin ; Zhou, Yaming

European journal of medicinal chemistry, 2023-10, Vol.258, p.115543-115543, Article 115543 [Periódico revisado por pares]

France: Elsevier Masson SAS

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