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Fostamatinib for the treatment of adult persistent and chronic immune thrombocytopenia: Results of two phase 3, randomized, placebo‐controlled trials
Fostamatinib for the treatment of adult persistent and chronic immune thrombocytopenia: Results of two phase 3, randomized, placebo‐controlled trials
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Fostamatinib for the treatment of adult persistent and chronic immune thrombocytopenia: Results of two phase 3, randomized, placebo‐controlled trials

Bussel, James ; Arnold, Donald M. ; Grossbard, Elliot ; Mayer, Jiří ; Treliński, Jacek ; Homenda, Wojciech ; Hellmann, Andrzej ; Windyga, Jerzy ; Sivcheva, Liliya ; Khalafallah, Alhossain A. ; Zaja, Francesco ; Cooper, Nichola ; Markovtsov, Vadim ; Zayed, Hany ; Duliege, Anne‐Marie

American journal of hematology, 2018-07, Vol.93 (7), p.921-930 [Periódico revisado por pares]

United States: Wiley Subscription Services, Inc

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2
Amyloid‐β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk‐AMPK pathway
Amyloid‐β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk‐AMPK pathway
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Amyloid‐β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk‐AMPK pathway

Jung, Eun Sun ; Suh, Kyujin ; Han, Jihui ; Kim, Heyyoung ; Kang, Hyung‐Sik ; Choi, Won‐Seok ; Mook‐Jung, Inhee

Aging cell, 2022-05, Vol.21 (5), p.e13623-n/a [Periódico revisado por pares]

England: John Wiley & Sons, Inc

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3
Loss of NF1 in Melanoma Confers Sensitivity to SYK Kinase Inhibition
Loss of NF1 in Melanoma Confers Sensitivity to SYK Kinase Inhibition
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Loss of NF1 in Melanoma Confers Sensitivity to SYK Kinase Inhibition

Abecunas, Cara ; Whitehead, Christopher E ; Ziemke, Elizabeth K ; Baumann, Douglas G ; Frankowski-McGregor, Christy L ; Sebolt-Leopold, Judith S ; Fallahi-Sichani, Mohammad

Cancer research (Chicago, Ill.), 2023-01, Vol.83 (2), p.316-331 [Periódico revisado por pares]

United States: American Association for Cancer Research

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4
Proapoptotic and immunomodulatory effects of SYK inhibitor entospletinib in combination with obinutuzumab in patients with chronic lymphocytic leukaemia
Proapoptotic and immunomodulatory effects of SYK inhibitor entospletinib in combination with obinutuzumab in patients with chronic lymphocytic leukaemia
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Proapoptotic and immunomodulatory effects of SYK inhibitor entospletinib in combination with obinutuzumab in patients with chronic lymphocytic leukaemia

Lam, Vi ; Best, Scott ; Kittai, Adam ; Orand, Kirsten ; Spurgeon, Stephen E. ; Liu, Tingting ; Danilov, Alexey V.

British journal of clinical pharmacology, 2022-02, Vol.88 (2), p.836-841 [Periódico revisado por pares]

England

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5
Oral spleen tyrosine kinase/Janus Kinase inhibitor gusacitinib for the treatment of chronic hand eczema: Results of a randomized phase 2 study
Oral spleen tyrosine kinase/Janus Kinase inhibitor gusacitinib for the treatment of chronic hand eczema: Results of a randomized phase 2 study
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Oral spleen tyrosine kinase/Janus Kinase inhibitor gusacitinib for the treatment of chronic hand eczema: Results of a randomized phase 2 study

Jimenez, Pablo A. ; Sofen, Howard L. ; Bissonnette, Robert ; Lee, Mark ; Fowler, Joseph ; Zammit, David J. ; Chen, Yusong ; Rao, Niranjan ; Denis, Louis ; Gupta, Sandeep

Journal of the American Academy of Dermatology, 2023-08, Vol.89 (2), p.235-242 [Periódico revisado por pares]

United States: Elsevier Inc

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6
A Phase I Trial of SYK Inhibition with Fostamatinib in the Prevention and Treatment of Chronic Graft-Versus-Host Disease
A Phase I Trial of SYK Inhibition with Fostamatinib in the Prevention and Treatment of Chronic Graft-Versus-Host Disease
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A Phase I Trial of SYK Inhibition with Fostamatinib in the Prevention and Treatment of Chronic Graft-Versus-Host Disease

Lin, Chenyu ; DiCioccio, Rachel A. ; Haykal, Tarek ; McManigle, William C. ; Li, Zhiguo ; Anand, Sarah M. ; Poe, Jonathan C. ; Bracken, Sonali J. ; Jia, Wei ; Alyea, Edwin P. ; Cardones, Adela R. ; Choi, Taewoong ; Gasparetto, Cristina ; Grunwald, Michael R. ; Hennig, Therese ; Kang, Yubin ; Long, Gwynn D. ; Lopez, Richard ; Martin, Melissa ; Minor, Kerry K. ; Quinones, Victor L. Perez ; Sung, Anthony D. ; Wiggins, Kristi ; Chao, Nelson J. ; Horwitz, Mitchell E. ; Rizzieri, David A. ; Sarantopoulos, Stefanie

Transplantation and cellular therapy, 2023-03, Vol.29 (3), p.179.e1-179.e10 [Periódico revisado por pares]

United States: Elsevier Inc

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7
Spleen tyrosine kinase inhibitor R406 has both antiviral and anti‐inflammatory effects on severe influenza A infection
Spleen tyrosine kinase inhibitor R406 has both antiviral and anti‐inflammatory effects on severe influenza A infection
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Spleen tyrosine kinase inhibitor R406 has both antiviral and anti‐inflammatory effects on severe influenza A infection

Luo, Junhao ; Gao, Yongjun ; Guo, Wenhui ; Zhao, Song ; Li, Li ; Zhang, Zhuohan ; Gao, Rongbao

Journal of medical virology, 2024-05, Vol.96 (5), p.e29678-n/a [Periódico revisado por pares]

United States: Wiley Subscription Services, Inc

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8
Tyrosine kinase SYK is a potential therapeutic target for liver fibrosis
Tyrosine kinase SYK is a potential therapeutic target for liver fibrosis
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Tyrosine kinase SYK is a potential therapeutic target for liver fibrosis

Qu, Chen ; Zheng, Dandan ; Li, Sai ; Liu, Yingjun ; Lidofsky, Anna ; Holmes, Jacinta A. ; Chen, Jianning ; He, Lu ; Wei, Lan ; Liao, Yadi ; Yuan, Hui ; Jin, Qimeng ; Lin, Zelong ; Hu, Qiaoting ; Jiang, Yuchuan ; Tu, Mengxian ; Chen, Xijun ; Li, Weiming ; Lin, Wenyu ; Fuchs, Bryan C. ; Chung, Raymond T. ; Hong, Jian

Hepatology (Baltimore, Md.), 2018-09, Vol.68 (3), p.1125-1139 [Periódico revisado por pares]

United States: Wiley Subscription Services, Inc

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9
Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia
Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia
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Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia

Cremer, Anjali ; Ellegast, Jana M ; Alexe, Gabriela ; Frank, Elizabeth S ; Ross, Linda ; Chu, S Haihua ; Pikman, Yana ; Robichaud, Amanda ; Goodale, Amy ; Häupl, Björn ; Mohr, Sebastian ; Rao, Arati V ; Walker, Alison R ; Blachly, James S ; Piccioni, Federica ; Armstrong, Scott A ; Byrd, John C ; Oellerich, Thomas ; Stegmaier, Kimberly

Cancer discovery, 2020-02, Vol.10 (2), p.214-231

United States

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10
Second‐Generation SYK Inhibitor Entospletinib Ameliorates Fully Established Inflammation and Bone Destruction in the Cherubism Mouse Model
Second‐Generation SYK Inhibitor Entospletinib Ameliorates Fully Established Inflammation and Bone Destruction in the Cherubism Mouse Model
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Second‐Generation SYK Inhibitor Entospletinib Ameliorates Fully Established Inflammation and Bone Destruction in the Cherubism Mouse Model

Yoshimoto, Tetsuya ; Hayashi, Tatsuhide ; Kondo, Toshio ; Kittaka, Mizuho ; Reichenberger, Ernst J ; Ueki, Yasuyoshi

Journal of bone and mineral research, 2018-08, Vol.33 (8), p.1513-1519 [Periódico revisado por pares]

United States: Wiley Subscription Services, Inc

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