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Material Type: Artigo
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Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40Yang, Haijuan ; Jiang, Xiaolu ; Li, Buren ; Yang, Hyo J ; Miller, Meredith ; Yang, Angela ; Dhar, Ankita ; Pavletich, Nikola PNature (London), 2017-12, Vol.552 (7685), p.368-373 [Periódico revisado por pares]England: Nature Publishing GroupTexto completo disponível |
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Material Type: Artigo
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Upregulation of Neuronal Rheb(S16H) for Hippocampal Protection in the Adult BrainMoon, Gyeong Joon ; Shin, Minsang ; Kim, Sang RyongInternational journal of molecular sciences, 2020-03, Vol.21 (6), p.2023 [Periódico revisado por pares]Switzerland: MDPI AGTexto completo disponível |
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Material Type: Artigo
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A small molecule inhibitor of Rheb selectively targets mTORC1 signalingMahoney, Sarah J ; Narayan, Sridhar ; Molz, Lisa ; Berstler, Lauren A ; Kang, Seong A ; Vlasuk, George P ; Saiah, EddineNature communications, 2018-02, Vol.9 (1), p.548-12, Article 548 [Periódico revisado por pares]England: Nature Publishing GroupTexto completo disponível |
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Material Type: Artigo
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MicroRNA-199a-5p Induced Autophagy and Inhibits the Pathogenesis of Ankylosing Spondylitis by Modulating the mTOR Signaling via Directly Targeting Ras Homolog Enriched in Brain (Rheb)Wang, Yahan ; Luo, Jianping ; Wang, Xiaogang ; Yang, Bin ; Cui, LiyangCellular Physiology and Biochemistry, 2017-10, Vol.42 (6), p.2481-2491 [Periódico revisado por pares]Germany: S. Karger AGTexto completo disponível |
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Material Type: Artigo
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Extensive molecular tinkering in the evolution of the membrane attachment mode of the Rheb GTPaseZáhonová, Kristína ; Petrželková, Romana ; Valach, Matus ; Yazaki, Euki ; Tikhonenkov, Denis V ; Butenko, Anzhelika ; Janouškovec, Jan ; Hrdá, Štěpánka ; Klimeš, Vladimír ; Burger, Gertraud ; Inagaki, Yuji ; Keeling, Patrick J ; Hampl, Vladimír ; Flegontov, Pavel ; Yurchenko, Vyacheslav ; Eliáš, MarekScientific reports, 2018-03, Vol.8 (1), p.5239-11, Article 5239 [Periódico revisado por pares]England: Nature Publishing GroupTexto completo disponível |
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Material Type: Artigo
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Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and RhebShi, Hao ; Chapman, Nicole M. ; Wen, Jing ; Guy, Cliff ; Long, Lingyun ; Dhungana, Yogesh ; Rankin, Sherri ; Pelletier, Stephane ; Vogel, Peter ; Wang, Hong ; Peng, Junmin ; Guan, Kun-Liang ; Chi, HongboImmunity (Cambridge, Mass.), 2019-12, Vol.51 (6), p.1012-1027.e7 [Periódico revisado por pares]United States: Elsevier IncTexto completo disponível |
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Material Type: Artigo
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Ubiquitination of Rheb governs growth factor-induced mTORC1 activationDeng, Lu ; Chen, Lei ; Zhao, Linlin ; Xu, Yan ; Peng, Xiaoping ; Wang, Xinbo ; Ding, Lin ; Jin, Jiali ; Teng, Hongqi ; Wang, Yanming ; Pan, Weijuan ; Yu, Fei ; Liao, Lujian ; Li, Li ; Ge, Xin ; Wang, PingCell research, 2019-02, Vol.29 (2), p.136-150 [Periódico revisado por pares]England: Nature Publishing GroupTexto completo disponível |
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Material Type: Artigo
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ER-associated degradation preserves hematopoietic stem cell quiescence and self-renewal by restricting mTOR activityLiu, Lu ; Inoki, Ayaka ; Fan, Kelly ; Mao, Fengbiao ; Shi, Guojun ; Jin, Xi ; Zhao, Meiling ; Ney, Gina ; Jones, Morgan ; Sun, Shengyi ; Dou, Yali ; Inoki, Ken ; Qi, Ling ; Li, QingBlood, 2020-12, Vol.136 (26), p.2975-2986 [Periódico revisado por pares]United States: Elsevier IncTexto completo disponível |
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Material Type: Artigo
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Role of RHEB in Regulating Differentiation Fate of Mesenchymal Stem Cells for Cartilage and Bone RegenerationAshraf, Sajjad ; Han, In-Bo ; Park, Hansoo ; Lee, Soo-HongInternational journal of molecular sciences, 2017-04, Vol.18 (4), p.880-880 [Periódico revisado por pares]Switzerland: MDPI AGTexto completo disponível |
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Material Type: Artigo
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LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth controlGan, Wenjian ; Dai, Xiaoming ; Dai, Xiangpeng ; Xie, Jun ; Yin, Shasha ; Zhu, Junjie ; Wang, Chen ; Liu, Yuchen ; Guo, Jianping ; Wang, Min ; Liu, Jing ; Hu, Jia ; Quinton, Ryan J ; Ganem, Neil J ; Liu, Pengda ; Asara, John M ; Pandolfi, Pier Paolo ; Yang, Yingzi ; He, Zhigang ; Gao, Guangping ; Wei, WenyiNature cell biology, 2020-02, Vol.22 (2), p.246-256 [Periódico revisado por pares]England: Nature Publishing GroupTexto completo disponível |