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1
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
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SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase

Zheng, Qinheng ; Woehl, Jordan L. ; Kitamura, Seiya ; Santos-Martins, Diogo ; Smedley, Christopher J. ; Li, Gencheng ; Forli, Stefano ; Moses, John E. ; Wolan, Dennis W. ; Sharpless, K. Barry

Proceedings of the National Academy of Sciences - PNAS, 2019-09, Vol.116 (38), p.18808-18814 [Periódico revisado por pares]

United States: National Academy of Sciences

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2
NSP4, an elastase-related protease in human neutrophils with arginine specificity
NSP4, an elastase-related protease in human neutrophils with arginine specificity
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NSP4, an elastase-related protease in human neutrophils with arginine specificity

Perera, Natascha C ; Schilling, Oliver ; Kittel, Heike ; Back, Walter ; Kremmer, Elisabeth ; Jenne, Dieter E

Proceedings of the National Academy of Sciences - PNAS, 2012-04, Vol.109 (16), p.6229-6234 [Periódico revisado por pares]

United States: National Academy of Sciences

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3
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors
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Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors

Cheng, Yunfei ; Li, Gencheng ; Smedley, Christopher J ; Giel, Marie-Claire ; Kitamura, Seiya ; Woehl, Jordan L ; Bianco, Giulia ; Forli, Stefano ; Homer, Joshua A ; Cappiello, John R ; Wolan, Dennis W ; Moses, John E ; Sharpless, K Barry

Proceedings of the National Academy of Sciences - PNAS, 2022-09, Vol.119 (37), p.e2208540119-e2208540119 [Periódico revisado por pares]

United States: National Academy of Sciences

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4
The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins
The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins
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The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins

Malaker, Stacy A. ; Pedram, Kayvon ; Ferracane, Michael J. ; Bensing, Barbara A. ; Krishnan, Venkatesh ; Pett, Christian ; Yu, Jin ; Woods, Elliot C. ; Kramer, Jessica R. ; Westerlind, Ulrika ; Dorigo, Oliver ; Bertozzi, Carolyn R.

Proceedings of the National Academy of Sciences - PNAS, 2019-04, Vol.116 (15), p.7278-7287 [Periódico revisado por pares]

United States: National Academy of Sciences

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5
Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein
Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein
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Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein

Schmidt, Karin ; Gardill, Bernd R. ; Kern, Alina ; Kirchweger, Peter ; Börsch, Michael ; Muller, Yves A.

Proceedings of the National Academy of Sciences - PNAS, 2018-05, Vol.115 (22), p.5744-5749 [Periódico revisado por pares]

United States: National Academy of Sciences

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6
15-Epi-LXA₄ and 17-epi-RvD1 restore TLR9-mediated impaired neutrophil phagocytosis and accelerate resolution of lung inflammation
15-Epi-LXA₄ and 17-epi-RvD1 restore TLR9-mediated impaired neutrophil phagocytosis and accelerate resolution of lung inflammation
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15-Epi-LXA₄ and 17-epi-RvD1 restore TLR9-mediated impaired neutrophil phagocytosis and accelerate resolution of lung inflammation

Sekheri, Meriem ; Kebir, Driss El ; Edner, Natalie ; Filep, János G.

Proceedings of the National Academy of Sciences - PNAS, 2020-04, Vol.117 (14), p.7971-7980 [Periódico revisado por pares]

Washington: National Academy of Sciences

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7
Human FAM111A inhibits vaccinia virus replication by degrading viral protein I3 and is antagonized by poxvirus host range factor SPI-1
Human FAM111A inhibits vaccinia virus replication by degrading viral protein I3 and is antagonized by poxvirus host range factor SPI-1
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Human FAM111A inhibits vaccinia virus replication by degrading viral protein I3 and is antagonized by poxvirus host range factor SPI-1

Zhu, Junda ; Gao, Xintao ; Li, Yijing ; Zhang, Zihui ; Xie, Shijie ; Ren, Shuning ; Li, Yarui ; Li, Hua ; Niu, Kang ; Fu, Shufang ; Deng, Yining ; Li, Yinü ; Moss, Bernard ; Wu, Wenxue ; Peng, Chen

Proceedings of the National Academy of Sciences - PNAS, 2023-08, Vol.120 (35), p.e2304242120-e2304242120 [Periódico revisado por pares]

United States: National Academy of Sciences

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8
The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells
The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells
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The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells

Kumagai, Jin ; Kiuchi, Masahiro ; Kokubo, Kota ; Yagyu, Hiroyuki ; Nemoto, Masahiro ; Tsuji, Kaori ; Nagahata, Ken ; Sasaki, Atsushi ; Hishiya, Takahisa ; Onoue, Miki ; Shinmi, Rie ; Sonobe, Yuri ; Iinuma, Tomohisa ; Yonekura, Syuji ; Shinga, Jun ; Hanazawa, Toyoyuki ; Koseki, Haruhiko ; Nakayama, Toshinori ; Yokote, Koutaro ; Hirahara, Kiyoshi

Proceedings of the National Academy of Sciences - PNAS, 2023-12, Vol.120 (49), p.e2302903120-e2302903120 [Periódico revisado por pares]

United States: National Academy of Sciences

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9
A reactive center loop-based prediction platform to enhance the design of therapeutic SERPINs
A reactive center loop-based prediction platform to enhance the design of therapeutic SERPINs
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A reactive center loop-based prediction platform to enhance the design of therapeutic SERPINs

Sanrattana, Wariya ; Sefiane, Thibaud ; Smits, Simone ; van Kleef, Nadine D ; Fens, Marcel H ; Lenting, Peter J ; Maas, Coen ; de Maat, Steven

Proceedings of the National Academy of Sciences - PNAS, 2021-11, Vol.118 (45), p.1 [Periódico revisado por pares]

United States: National Academy of Sciences

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10
Discovery of potent thrombin inhibitors from a protease-focused DNA-encoded chemical library
Discovery of potent thrombin inhibitors from a protease-focused DNA-encoded chemical library
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Discovery of potent thrombin inhibitors from a protease-focused DNA-encoded chemical library

Dawadi, Surendra ; Simmons, Nicholas ; Miklossy, Gabriella ; Bohren, Kurt M. ; Faver, John C. ; Ucisik, Melek Nihan ; Nyshadham, Pranavanand ; Yu, Zhifeng ; Matzuk, Martin M.

Proceedings of the National Academy of Sciences - PNAS, 2020-07, Vol.117 (29), p.16782-16789 [Periódico revisado por pares]

Washington: National Academy of Sciences

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