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1
Excellence in Medicinal Chemistry: Celebrating ACS Medicinal Chemistry Division (MEDI) Awards. A Call for Nominations
Excellence in Medicinal Chemistry: Celebrating ACS Medicinal Chemistry Division (MEDI) Awards. A Call for Nominations
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Excellence in Medicinal Chemistry: Celebrating ACS Medicinal Chemistry Division (MEDI) Awards. A Call for Nominations

Blanco, Maria-Jesus ; Bryant-Friedrich, Amanda ; Georg, Gunda ; Ali, Amjad ; Ornstein, Paul L. ; Ferrins, Lori

Journal of medicinal chemistry, 2023-06, Vol.66 (11), p.7067-7069 [Periódico revisado por pares]

United States: American Chemical Society

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2
Design, Synthesis, and Pharmacological Characterization of Heterobivalent Ligands for the Putative 5‑HT2A/mGlu2 Receptor Complex
Design, Synthesis, and Pharmacological Characterization of Heterobivalent Ligands for the Putative 5‑HT2A/mGlu2 Receptor Complex
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Design, Synthesis, and Pharmacological Characterization of Heterobivalent Ligands for the Putative 5‑HT2A/mGlu2 Receptor Complex

Poulie, Christian B. M ; Liu, Na ; Jensen, Anders A ; Bunch, Lennart

Journal of medicinal chemistry, 2020-09, Vol.63 (17), p.9928-9949 [Periódico revisado por pares]

American Chemical Society

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3
A Survey of the Structures of US FDA Approved Combination Drugs
A Survey of the Structures of US FDA Approved Combination Drugs
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A Survey of the Structures of US FDA Approved Combination Drugs

Das, Pradipta ; Delost, Michael D ; Qureshi, Munaum H ; Smith, David T ; Njardarson, Jon T

Journal of medicinal chemistry, 2019-05, Vol.62 (9), p.4265-4311 [Periódico revisado por pares]

United States: American Chemical Society

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4
Targets for Drug Therapy for Autism Spectrum Disorder: Challenges and Future Directions
Targets for Drug Therapy for Autism Spectrum Disorder: Challenges and Future Directions
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Targets for Drug Therapy for Autism Spectrum Disorder: Challenges and Future Directions

Lacivita, Enza ; Perrone, Roberto ; Margari, Lucia ; Leopoldo, Marcello

Journal of medicinal chemistry, 2017-11, Vol.60 (22), p.9114-9141 [Periódico revisado por pares]

United States: American Chemical Society

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5
Discovery of (1S,2R,3S,4S,5R,6R)‑2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity
Discovery of (1S,2R,3S,4S,5R,6R)‑2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity
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Discovery of (1S,2R,3S,4S,5R,6R)‑2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity

Chappell, Mark D ; Li, Renhua ; Smith, Stephon C ; Dressman, Bruce A ; Tromiczak, Eric G ; Tripp, Allie E ; Blanco, Maria-Jesus ; Vetman, Tatiana ; Quimby, Steven J ; Matt, James ; Britton, Thomas C ; Fivush, Adam M ; Schkeryantz, Jeffrey M ; Mayhugh, Daniel ; Erickson, Jon A ; Bures, Mark G ; Jaramillo, Carlos ; Carpintero, Mercedes ; Diego, José Eugenio de ; Barberis, Mario ; Garcia-Cerrada, Susana ; Soriano, José F ; Antonysamy, Stephen ; Atwell, Shane ; MacEwan, Iain ; Condon, Bradley ; Sougias, Christine ; Wang, Jing ; Zhang, Aiping ; Conners, Kris ; Groshong, Chris ; Wasserman, Stephen R ; Koss, John W ; Witkin, Jeffrey M ; Li, Xia ; Overshiner, Carl ; Wafford, Keith A ; Seidel, Wesley ; Wang, Xu-Shan ; Heinz, Beverly A ; Swanson, Steven ; Catlow, John T ; Bedwell, David W ; Monn, James A ; Mitch, Charles H ; Ornstein, Paul L

Journal of medicinal chemistry, 2016-12, Vol.59 (24), p.10974-10993 [Periódico revisado por pares]

United States: American Chemical Society

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6
Unusual Amino Acids in Medicinal Chemistry
Unusual Amino Acids in Medicinal Chemistry
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Unusual Amino Acids in Medicinal Chemistry

Blaskovich, Mark A. T

Journal of medicinal chemistry, 2016-12, Vol.59 (24), p.10807-10836 [Periódico revisado por pares]

United States: American Chemical Society

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7
Discovery of the First α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ‑8
Discovery of the First α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ‑8
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Discovery of the First α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ‑8

Gardinier, Kevin M ; Gernert, Douglas L ; Porter, Warren J ; Reel, Jon K ; Ornstein, Paul L ; Spinazze, Patrick ; Stevens, F. Craig ; Hahn, Patric ; Hollinshead, Sean P ; Mayhugh, Daniel ; Schkeryantz, Jeff ; Khilevich, Albert ; De Frutos, Oscar ; Gleason, Scott D ; Kato, Akihiko S ; Luffer-Atlas, Debra ; Desai, Prashant V ; Swanson, Steven ; Burris, Kevin D ; Ding, Chunjin ; Heinz, Beverly A ; Need, Anne B ; Barth, Vanessa N ; Stephenson, Gregory A ; Diseroad, Benjamin A ; Woods, Tim A ; Yu, Hong ; Bredt, David ; Witkin, Jeffrey M

Journal of medicinal chemistry, 2016-05, Vol.59 (10), p.4753-4768 [Periódico revisado por pares]

United States: American Chemical Society

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8
4‑((R)‑2-{[6-((S)‑3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)­piperazine-1-carboxylic Acid Butyl Ester (ACT-246475) and Its Prodrug (ACT-281959), a Novel P2Y12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel
4‑((R)‑2-{[6-((S)‑3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)­piperazine-1-carboxylic Acid Butyl Ester (ACT-246475) and Its Prodrug (ACT-281959), a Novel P2Y12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel
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4‑((R)‑2-{[6-((S)‑3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)­piperazine-1-carboxylic Acid Butyl Ester (ACT-246475) and Its Prodrug (ACT-281959), a Novel P2Y12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel

Caroff, Eva ; Hubler, Francis ; Meyer, Emmanuel ; Renneberg, Dorte ; Gnerre, Carmela ; Treiber, Alexander ; Rey, Markus ; Hess, Patrick ; Steiner, Beat ; Hilpert, Kurt ; Riederer, Markus A

Journal of medicinal chemistry, 2015-12, Vol.58 (23), p.9133-9153 [Periódico revisado por pares]

United States: American Chemical Society

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9
Design of 4‑Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2
Design of 4‑Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2
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Design of 4‑Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2

Felts, Andrew S ; Rodriguez, Alice L ; Smith, Katrina A ; Engers, Julie L ; Morrison, Ryan D ; Byers, Frank W ; Blobaum, Anna L ; Locuson, Charles W ; Chang, Sichen ; Venable, Daryl F ; Niswender, Colleen M ; Daniels, J. Scott ; Conn, P. Jeffrey ; Lindsley, Craig W ; Emmitte, Kyle A

Journal of medicinal chemistry, 2015-11, Vol.58 (22), p.9027-9040 [Periódico revisado por pares]

United States: American Chemical Society

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10
Development of Novel PET Probes for Central 2‑Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic Acid Receptors
Development of Novel PET Probes for Central 2‑Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic Acid Receptors
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Development of Novel PET Probes for Central 2‑Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic Acid Receptors

Oi, Norihito ; Tokunaga, Masaki ; Suzuki, Michiyuki ; Nagai, Yuji ; Nakatani, Yosuke ; Yamamoto, Noboru ; Maeda, Jun ; Minamimoto, Takafumi ; Zhang, Ming-Rong ; Suhara, Tetsuya ; Higuchi, Makoto

Journal of medicinal chemistry, 2015-11, Vol.58 (21), p.8444-8462 [Periódico revisado por pares]

United States: American Chemical Society

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