Genomic Methods Identify Homologous Recombination Deficiency in Pancreas Adenocarcinoma and Optimize Treatment Selection

Park, Wungki ; Chen, Jiapeng ; Chou, Joanne F ; Varghese, Anna M ; Yu, Kenneth H ; Wong, Winston ; Capanu, Marinela ; Balachandran, Vinod ; McIntyre, Caitlin A ; El Dika, Imane ; Khalil, Danny N ; Harding, James J ; Ghalehsari, Nima ; McKinnell, Zoe ; Chalasani, Sree B ; Makarov, Vladimir ; Selenica, Pier ; Pei, Xin ; Lecomte, Nicolas ; Kelsen, David P ; Abou-Alfa, Ghassan K ; Robson, Mark E ; Zhang, Liying ; Berger, Michael F ; Schultz, Nikolaus ; Chan, Timothy A ; Powell, Simon N ; Reis-Filho, Jorge S ; Iacobuzio-Donahue, Christine A ; Riaz, Nadeem ; O'Reilly, Eileen M

United States

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Activation of the IFN Signaling Pathway is Associated with Resistance to CDK4/6 Inhibitors and Immune Checkpoint Activation in ER-Positive Breast Cancer

De Angelis, Carmine ; Fu, Xiaoyong ; Cataldo, Maria Letizia ; Nardone, Agostina ; Pereira, Resel ; Veeraraghavan, Jamunarani ; Nanda, Sarmistha ; Qin, Lanfang ; Sethunath, Vidyalakshmi ; Wang, Tao ; Hilsenbeck, Susan G ; Benelli, Matteo ; Migliaccio, Ilenia ; Guarducci, Cristina ; Malorni, Luca ; Litchfield, Lacey M ; Liu, Jiangang ; Donaldson, Joshua ; Selenica, Pier ; Brown, David N ; Weigelt, Britta ; Reis-Filho, Jorge S ; Park, Ben H ; Hurvitz, Sara A ; Slamon, Dennis J ; Rimawi, Mothaffar F ; Jansen, Valerie M ; Jeselsohn, Rinath ; Osborne, C Kent ; Schiff, Rachel

United States

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EGFRvIII Deletion Mutations in Pediatric High-Grade Glioma and Response to Targeted Therapy in Pediatric Glioma Cell Lines

BAX, Dorine A ; GASPAR, Nathalie ; STAVALE, João N ; AL-SARRAJ, Safa ; REIS, Rui M ; VASSAL, Gilles ; PEARSON, Andrew D. J ; HARGRAVE, Darren ; ELLISON, David W ; WORKMAN, Paul ; JONES, Chris ; LITTLE, Suzanne E ; MARSHALL, Lynley ; PERRYMAN, Lara ; REGAIRAZ, Marie ; VIANA-PEREIRA, Marta ; VUONONVIRTA, Raisa ; SHARP, Swee Y ; REIS-FILHO, Jorge S

Philadelphia, PA: American Association for Cancer Research

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Whole-Exome Sequencing Analysis of the Progression from Non-Low-Grade Ductal Carcinoma In Situ to Invasive Ductal Carcinoma

Pareja, Fresia ; Brown, David N ; Lee, Ju Youn ; Da Cruz Paula, Arnaud ; Selenica, Pier ; Bi, Rui ; Geyer, Felipe C ; Gazzo, Andrea ; da Silva, Edaise M ; Vahdatinia, Mahsa ; Stylianou, Anthe A ; Ferrando, Lorenzo ; Wen, Hannah Y ; Hicks, James B ; Weigelt, Britta ; Reis-Filho, Jorge S

United States

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Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors

Shukla, Neerav ; Somwar, Romel ; Smith, Roger S ; Ambati, Sri ; Munoz, Stanley ; Merchant, Melinda ; D'Arcy, Padraig ; Wang, Xin ; Kobos, Rachel ; Antczak, Christophe ; Bhinder, Bhavneet ; Shum, David ; Radu, Constantin ; Yang, Guangbin ; Taylor, Barry S ; Ng, Charlotte K Y ; Weigelt, Britta ; Khodos, Inna ; de Stanchina, Elisa ; Reis-Filho, Jorge S ; Ouerfelli, Ouathek ; Linder, Stig ; Djaballah, Hakim ; Ladanyi, Marc

United States

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High-Sensitivity Mutation Analysis of Cell-Free DNA for Disease Monitoring in Endometrial Cancer

Ashley, Charles W ; Selenica, Pier ; Patel, Juber ; Wu, Michelle ; Nincevic, Josip ; Lakhman, Yulia ; Zhou, Qin ; Shah, Ronak H ; Berger, Michael F ; Da Cruz Paula, Arnaud ; Brown, David N ; Marra, Antonio ; Iasonos, Alexia ; Momeni-Boroujeni, Amir ; Alektiar, Kaled M ; Long Roche, Kara ; Zivanovic, Oliver ; Mueller, Jennifer J ; Zamarin, Dmitriy ; Broach, Vance A ; Sonoda, Yukio ; Leitao, Mario M ; Friedman, Claire F ; Jewell, Elizabeth ; Reis-Filho, Jorge S ; Ellenson, Lora H ; Aghajanian, Carol ; Abu-Rustum, Nadeem R ; Cadoo, Karen ; Weigelt, Britta

United States

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PI3K Pathway Activation in High-Grade Ductal Carcinoma In Situ―Implications for Progression to Invasive Breast Carcinoma

SAKR, Rita A ; WEIGELT, Britta ; KING, Tari A ; CHANDARLAPATY, Sarat ; ANDRADE, Victor P ; GUERINI-ROCCO, Elena ; GIRI, Dilip ; NG, Charlotte K. Y ; COWELL, Catherine F ; ROSEN, Neal ; REIS, Jorge S

Philadelphia, PA: American Association for Cancer Research

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Correction: Activation of the IFN Signaling Pathway is Associated with Resistance to CDK4/6 Inhibitors and Immune Checkpoint Activation in ER-Positive Breast Cancer

De Angelis, Carmine ; Fu, Xiaoyong ; Cataldo, Maria Letizia ; Nardone, Agostina ; Pereira, Resel ; Veeraraghavan, Jamunarani ; Nanda, Sarmistha ; Qin, Lanfang ; Sethunath, Vidyalakshmi ; Wang, Tao ; Hilsenbeck, Susan G ; Benelli, Matteo ; Migliaccio, Ilenia ; Guarducci, Cristina ; Malorni, Luca ; Litchfield, Lacey M ; Liu, Jiangang ; Donaldson, Joshua ; Selenica, Pier ; Brown, David N ; Weigelt, Britta ; Reis-Filho, Jorge S ; Park, Ben H ; Hurvitz, Sara A ; Slamon, Dennis J ; Rimawi, Mothaffar F ; Jansen, Valerie M ; Jeselsohn, Rinath ; Osborne, C Kent ; Schiff, Rachel

United States

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Abstract P6-09-01: RAD51B loss-of-function variants confer susceptibility to hereditary breast and ovarian cancers and result in tumors with genomic features of homologous recombination repair defects

Mandelker, Diana SReis-FilhoReis-Filho ; Mukherjee, Semanti ; Setton, Jeremy ; Selenica, Pier ; Kemel, Yelena ; Ceyhan-Birsoy, Ozge ; Sheehan, Margaret ; Tkachuk, Kaitlyn ; Brown, David N ; Powell, Simon ; Weigelt, Britta ; Robson, Mark E ; Riaz, Nadeem ; Offit, Kenneth ; Reis-Filho, Jorge S

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Abstract P2-06-04: Pathognomonic long molecule footprints of backup repair pathways in homologous recombination deficient cancers

Setton, Jeremy ; Hadi, Kevin ; Tian, Huasong ; Paula, Arnaud Da Cruz ; Rosiene, Joel ; Choo, Zi-Ning ; Behr, Julie ; Yao, Xiaotong ; Elemento, Olivier ; Weigelt, Britta ; Riaz, Nadeem ; Reis-Filho, Jorge S ; Imielinski, Marcin ; Powell, Simon N

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