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Refinado por: Nome da Publicação: Journal Of Medicinal Chemistry remover assunto: Life Sciences & Biomedicine remover
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1
Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation
Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation
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Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation

Dorel, Ruth ; Sun, Dawei ; Carruthers, Nicholas ; Castanedo, Georgette M. ; Ung, Peter M.-U. ; Factor, Daniel C. ; Li, Tianbo ; Baumann, Hannah ; Janota, Danielle ; Pang, Jodie ; Salphati, Laurent ; Meklemburg, Robert ; Korman, Allison J. ; Harper, Halie E. ; Stubblefield, Samantha ; Payandeh, Jian ; McHugh, Daniel ; Lang, Bradley T. ; Tesar, Paul J. ; Dere, Edward ; Masureel, Matthieu ; Adams, Drew J. ; Volgraf, Matthew ; Braun, Marie-Gabrielle

Journal of medicinal chemistry, 2024-03, Vol.67 (6), p.4819-4832 [Periódico revisado por pares]

United States: American Chemical Society

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2
Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα
Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα
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Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα

Hanan, Emily J. ; Braun, Marie-Gabrielle ; Heald, Robert A. ; MacLeod, Calum ; Chan, Connie ; Clausen, Saundra ; Edgar, Kyle A. ; Eigenbrot, Charles ; Elliott, Richard ; Endres, Nicholas ; Friedman, Lori S. ; Gogol, Emily ; Gu, Xiao-Hui ; Thibodeau, Rebecca Hong ; Jackson, Philip S. ; Kiefer, James R. ; Knight, Jamie D. ; Nannini, Michelle ; Narukulla, Raman ; Pace, Amanda ; Pang, Jodie ; Purkey, Hans E. ; Salphati, Laurent ; Sampath, Deepak ; Schmidt, Stephen ; Sideris, Steve ; Song, Kyung ; Sujatha-Bhaskar, Swathi ; Ultsch, Mark ; Wallweber, Heidi ; Xin, Jianfeng ; Yeap, SiewKuen ; Young, Amy ; Zhong, Yu ; Staben, Steven T.

Journal of medicinal chemistry, 2022-12, Vol.65 (24), p.16589-16621 [Periódico revisado por pares]

United States: American Chemical Society

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3
Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta
Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta
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Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta

Stockley, Martin L. ; Ferdinand, Amanda ; Benedetti, Giovanni ; Blencowe, Peter ; Boyd, Susan M. ; Calder, Mat ; Charles, Mark D. ; Edwardes, Lucy V. ; Ekwuru, Tennyson ; Finch, Harry ; Galbiati, Alessandro ; Geo, Lerin ; Grande, Diego ; Grinkevich, Vera ; Holliday, Nicholas D. ; Krajewski, Wojciech W. ; MacDonald, Ellen ; Majithiya, Jayesh B. ; McCarron, Hollie ; McWhirter, Claire L. ; Patel, Viral ; Pedder, Chris ; Rajendra, Eeson ; Ranzani, Marco ; Rigoreau, Laurent J. M. ; Robinson, Helen M. R. ; Schaedler, Theresia ; Sirina, Julija ; Smith, Graeme C. M. ; Swarbrick, Martin E. ; Turnbull, Andrew P. ; Willis, Simon ; Heald, Robert A.

Journal of medicinal chemistry, 2022-10, Vol.65 (20), p.13879-13891 [Periódico revisado por pares]

United States: American Chemical Society

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4
Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor
Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor
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Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor

Miller, Duncan C. ; Reuillon, Tristan ; Molyneux, Lauren ; Blackburn, Timothy ; Cook, Simon J. ; Edwards, Noel ; Endicott, Jane A. ; Golding, Bernard T. ; Griffin, Roger J. ; Hardcastle, Ian ; Harnor, Suzannah J. ; Heptinstall, Amy ; Lochhead, Pamela ; Martin, Mathew P. ; Martin, Nick C. ; Myers, Stephanie ; Newell, David R. ; Noble, Richard A. ; Phillips, Nicole ; Rigoreau, Laurent ; Thomas, Huw ; Tucker, Julie A. ; Wang, Lan-Zhen ; Waring, Michael J. ; Wong, Ai-Ching ; Wedge, Stephen R. ; Noble, Martin E. M. ; Cano, Celine

Journal of medicinal chemistry, 2022-05, Vol.65 (9), p.6513-6540 [Periódico revisado por pares]

United States: American Chemical Society

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5
Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1)
Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1)
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Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1)

Williamson, Douglas S ; Smith, Garrick P ; Acheson-Dossang, Pamela ; Bedford, Simon T ; Chell, Victoria ; Chen, I-Jen ; Daechsel, Justus C. A ; Daniels, Zoe ; David, Laurent ; Dokurno, Pawel ; Hentzer, Morten ; Herzig, Martin C ; Hubbard, Roderick E ; Moore, Jonathan D ; Murray, James B ; Newland, Samantha ; Ray, Stuart C ; Shaw, Terry ; Surgenor, Allan E ; Terry, Lindsey ; Thirstrup, Kenneth ; Wang, Yikang ; Christensen, Kenneth V

Journal of medicinal chemistry, 2017-11, Vol.60 (21), p.8945-8962 [Periódico revisado por pares]

United States: American Chemical Society

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6
Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties
Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties
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Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties

Dyck, Brian ; Branstetter, Bryan ; Gharbaoui, Tawfik ; Hudson, Andrew R ; Breitenbucher, J. Guy ; Gomez, Laurent ; Botrous, Iriny ; Marrone, Tami ; Barido, Richard ; Allerston, Charles K ; Cedervall, E. Peder ; Xu, Rui ; Sridhar, Vandana ; Barker, Ryan ; Aertgeerts, Kathleen ; Schmelzer, Kara ; Neul, David ; Lee, Dong ; Massari, Mark Eben ; Andersen, Carsten B ; Sebring, Kristen ; Zhou, Xianbo ; Petroski, Robert ; Limberis, James ; Augustin, Martin ; Chun, Lawrence E ; Edwards, Thomas E ; Peters, Marco ; Tabatabaei, Ali

Journal of medicinal chemistry, 2017-04, Vol.60 (8), p.3472-3483 [Periódico revisado por pares]

United States: American Chemical Society

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7
New 6‑Aminoquinoxaline Derivatives with Neuroprotective Effect on Dopaminergic Neurons in Cellular and Animal Parkinson Disease Models
New 6‑Aminoquinoxaline Derivatives with Neuroprotective Effect on Dopaminergic Neurons in Cellular and Animal Parkinson Disease Models
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New 6‑Aminoquinoxaline Derivatives with Neuroprotective Effect on Dopaminergic Neurons in Cellular and Animal Parkinson Disease Models

Le Douaron, Gael ; Ferrié, Laurent ; Sepulveda-Diaz, Julia E ; Amar, Majid ; Harfouche, Abha ; Séon-Méniel, Blandine ; Raisman-Vozari, Rita ; Michel, Patrick P ; Figadère, Bruno

Journal of medicinal chemistry, 2016-07, Vol.59 (13), p.6169-6186 [Periódico revisado por pares]

United States: American Chemical Society

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8
Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1
Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1
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Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

Llona-Minguez, Sabin ; Höglund, Andreas ; Jacques, Sylvain A ; Johansson, Lars ; Calderón-Montaño, José Manuel ; Claesson, Magnus ; Loseva, Olga ; Valerie, Nicholas C. K ; Lundbäck, Thomas ; Piedrafita, Javier ; Maga, Giovanni ; Crespan, Emmanuele ; Meijer, Laurent ; Burgos Morón, Estefanía ; Baranczewski, Pawel ; Hagbjörk, Ann-Louise ; Svensson, Richard ; Wiita, Elisee ; Almlöf, Ingrid ; Visnes, Torkild ; Jeppsson, Fredrik ; Sigmundsson, Kristmundur ; Jensen, Annika Jenmalm ; Artursson, Per ; Jemth, Ann-Sofie ; Stenmark, Pål ; Warpman Berglund, Ulrika ; Scobie, Martin ; Helleday, Thomas

Journal of medicinal chemistry, 2016-02, Vol.59 (3), p.1140-1148 [Periódico revisado por pares]

United States: American Chemical Society

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9
Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3
Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3
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Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3

Boyd, Scott ; Brookfield, Joanna L ; Critchlow, Susan E ; Cumming, Iain A ; Curtis, Nicola J ; Debreczeni, Judit ; Degorce, Sébastien L ; Donald, Craig ; Evans, Nicola J ; Groombridge, Sam ; Hopcroft, Philip ; Jones, Neil P ; Kettle, Jason G ; Lamont, Scott ; Lewis, Hilary J ; MacFaull, Philip ; McLoughlin, Sheila B ; Rigoreau, Laurent J. M ; Smith, James M ; St-Gallay, Steve ; Stock, Julie K ; Turnbull, Andrew P ; Wheatley, Edward R ; Winter, Jon ; Wingfield, Jonathan

Journal of medicinal chemistry, 2015-04, Vol.58 (8), p.3611-3625 [Periódico revisado por pares]

United States: American Chemical Society

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10
Structure–Activity Relationships and Design of Viral Mutagens and Application to Lethal Mutagenesis
Structure–Activity Relationships and Design of Viral Mutagens and Application to Lethal Mutagenesis
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Structure–Activity Relationships and Design of Viral Mutagens and Application to Lethal Mutagenesis

Bonnac, Laurent F ; Mansky, Louis M ; Patterson, Steven E

Journal of medicinal chemistry, 2013-12, Vol.56 (23), p.9403-9414 [Periódico revisado por pares]

United States: American Chemical Society

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