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Excellence in Medicinal Chemistry: Celebrating ACS Medicinal Chemistry Division (MEDI) Awards. A Call for Nominations
Excellence in Medicinal Chemistry: Celebrating ACS Medicinal Chemistry Division (MEDI) Awards. A Call for Nominations
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Excellence in Medicinal Chemistry: Celebrating ACS Medicinal Chemistry Division (MEDI) Awards. A Call for Nominations

Blanco, Maria-Jesus ; Bryant-Friedrich, Amanda ; Georg, Gunda ; Ali, Amjad ; Ornstein, Paul L. ; Ferrins, Lori

Journal of medicinal chemistry, 2023-06, Vol.66 (11), p.7067-7069 [Periódico revisado por pares]

United States: American Chemical Society

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2
Discovery of (1S,2R,3S,4S,5R,6R)‑2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity
Discovery of (1S,2R,3S,4S,5R,6R)‑2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity
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Discovery of (1S,2R,3S,4S,5R,6R)‑2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity

Chappell, Mark D ; Li, Renhua ; Smith, Stephon C ; Dressman, Bruce A ; Tromiczak, Eric G ; Tripp, Allie E ; Blanco, Maria-Jesus ; Vetman, Tatiana ; Quimby, Steven J ; Matt, James ; Britton, Thomas C ; Fivush, Adam M ; Schkeryantz, Jeffrey M ; Mayhugh, Daniel ; Erickson, Jon A ; Bures, Mark G ; Jaramillo, Carlos ; Carpintero, Mercedes ; Diego, José Eugenio de ; Barberis, Mario ; Garcia-Cerrada, Susana ; Soriano, José F ; Antonysamy, Stephen ; Atwell, Shane ; MacEwan, Iain ; Condon, Bradley ; Sougias, Christine ; Wang, Jing ; Zhang, Aiping ; Conners, Kris ; Groshong, Chris ; Wasserman, Stephen R ; Koss, John W ; Witkin, Jeffrey M ; Li, Xia ; Overshiner, Carl ; Wafford, Keith A ; Seidel, Wesley ; Wang, Xu-Shan ; Heinz, Beverly A ; Swanson, Steven ; Catlow, John T ; Bedwell, David W ; Monn, James A ; Mitch, Charles H ; Ornstein, Paul L

Journal of medicinal chemistry, 2016-12, Vol.59 (24), p.10974-10993 [Periódico revisado por pares]

United States: American Chemical Society

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3
Discovery of the First α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ‑8
Discovery of the First α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ‑8
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Discovery of the First α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ‑8

Gardinier, Kevin M ; Gernert, Douglas L ; Porter, Warren J ; Reel, Jon K ; Ornstein, Paul L ; Spinazze, Patrick ; Stevens, F. Craig ; Hahn, Patric ; Hollinshead, Sean P ; Mayhugh, Daniel ; Schkeryantz, Jeff ; Khilevich, Albert ; De Frutos, Oscar ; Gleason, Scott D ; Kato, Akihiko S ; Luffer-Atlas, Debra ; Desai, Prashant V ; Swanson, Steven ; Burris, Kevin D ; Ding, Chunjin ; Heinz, Beverly A ; Need, Anne B ; Barth, Vanessa N ; Stephenson, Gregory A ; Diseroad, Benjamin A ; Woods, Tim A ; Yu, Hong ; Bredt, David ; Witkin, Jeffrey M

Journal of medicinal chemistry, 2016-05, Vol.59 (10), p.4753-4768 [Periódico revisado por pares]

United States: American Chemical Society

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4
Synthesis and Structure−Activity Relationships of Novel Arylpiperazines as Potent and Selective Agonists of the Melanocortin Subtype-4 Receptor
Synthesis and Structure−Activity Relationships of Novel Arylpiperazines as Potent and Selective Agonists of the Melanocortin Subtype-4 Receptor
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Synthesis and Structure−Activity Relationships of Novel Arylpiperazines as Potent and Selective Agonists of the Melanocortin Subtype-4 Receptor

Richardson, Timothy I ; Ornstein, Paul L ; Briner, Karin ; Fisher, Matthew J ; Backer, Ryan T ; Biggers, C. Kelly ; Clay, Michael P ; Emmerson, Paul J ; Hertel, Larry W ; Hsiung, Hansen M ; Husain, Saba ; Kahl, Steven D ; Lee, Jonathan A ; Lindstrom, Terry D ; Martinelli, Michael J ; Mayer, John P ; Mullaney, Jeffery T ; O'Brien, Thomas P ; Pawlak, Joseph M ; Revell, Kevin D ; Shah, Jikesh ; Zgombick, John M ; Herr, R. Jason ; Melekhov, Alex ; Sampson, Peter B ; King, Chi-Hsin R

Journal of medicinal chemistry, 2004-01, Vol.47 (3), p.744-755 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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5
Ethyl (3S,4aR,6S,8aR)-6-(4-Ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso- quinoline-3-carboxylic Ester:  A Prodrug of a GluR5 Kainate Receptor Antagonist Active in Two Animal Models of Acute Migraine
Ethyl (3S,4aR,6S,8aR)-6-(4-Ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso- quinoline-3-carboxylic Ester:  A Prodrug of a GluR5 Kainate Receptor Antagonist Active in Two Animal Models of Acute Migraine
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Ethyl (3S,4aR,6S,8aR)-6-(4-Ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso- quinoline-3-carboxylic Ester:  A Prodrug of a GluR5 Kainate Receptor Antagonist Active in Two Animal Models of Acute Migraine

Filla, Sandra A ; Winter, Mark A ; Johnson, Kirk W ; Bleakman, David ; Bell, Michael G ; Bleisch, Thomas J ; Castaño, Ana M ; Clemens-Smith, Amy ; del Prado, Miriam ; Dieckman, Donna K ; Dominguez, Esteban ; Escribano, Ana ; Ho, Ken H ; Hudziak, Kevin J ; Katofiasc, Mary A ; Martinez-Perez, Jose A ; Mateo, Ana ; Mathes, Brian M ; Mattiuz, Edward L ; Ogden, Ann Marie L ; Phebus, Lee A ; Stack, Douglas R ; Stratford, Robert E ; Ornstein, Paul L

Journal of medicinal chemistry, 2002-09, Vol.45 (20), p.4383-4386 [Periódico revisado por pares]

United States: American Chemical Society

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6
Biarylpropylsulfonamides as Novel, Potent Potentiators of 2-Amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic Acid (AMPA) Receptors
Biarylpropylsulfonamides as Novel, Potent Potentiators of 2-Amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic Acid (AMPA) Receptors
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Biarylpropylsulfonamides as Novel, Potent Potentiators of 2-Amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic Acid (AMPA) Receptors

Ornstein, Paul L ; Zimmerman, Dennis M ; Arnold, M. Brian ; Bleisch, Thomas J ; Cantrell, Buddy ; Simon, Richard ; Zarrinmayeh, Hamideh ; Baker, S. Richard ; Gates, Mary ; Tizzano, Joseph P ; Bleakman, David ; Mandelzys, Allan ; Jarvie, Kieth R ; Ho, Ken ; Deverill, Michelle ; Kamboj, Rajender K

Journal of medicinal chemistry, 2000-11, Vol.43 (23), p.4354-4358 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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7
Synthesis and Evaluation of a Series of Novel 2-[(4-Chlorophenoxy)methyl]- benzimidazoles as Selective Neuropeptide Y Y1 Receptor Antagonists
Synthesis and Evaluation of a Series of Novel 2-[(4-Chlorophenoxy)methyl]- benzimidazoles as Selective Neuropeptide Y Y1 Receptor Antagonists
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Synthesis and Evaluation of a Series of Novel 2-[(4-Chlorophenoxy)methyl]- benzimidazoles as Selective Neuropeptide Y Y1 Receptor Antagonists

Zarrinmayeh, Hamideh ; Nunes, Anne M ; Ornstein, Paul L ; Zimmerman, Dennis M ; Arnold, M. Brian ; Schober, Douglas A ; Gackenheimer, Susan L ; Bruns, Robert F ; Hipskind, Philip A ; Britton, Thomas C ; Cantrell, Buddy E ; Gehlert, Donald R

Journal of medicinal chemistry, 1998-07, Vol.41 (15), p.2709-2719 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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8
2-Substituted (2SR)-2-Amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 1. Effects of Alkyl, Arylalkyl, and Diarylalkyl Substitution
2-Substituted (2SR)-2-Amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 1. Effects of Alkyl, Arylalkyl, and Diarylalkyl Substitution
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2-Substituted (2SR)-2-Amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 1. Effects of Alkyl, Arylalkyl, and Diarylalkyl Substitution

Ornstein, Paul L ; Bleisch, Thomas J ; Arnold, M. Brian ; Wright, Rebecca A ; Johnson, Bryan G ; Schoepp, Darryle D

Journal of medicinal chemistry, 1998-01, Vol.41 (3), p.346-357 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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9
2-Substituted (2SR)-2-Amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 2. Effects of Aromatic Substitution, Pharmacological Characterization, and Bioavailability
2-Substituted (2SR)-2-Amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 2. Effects of Aromatic Substitution, Pharmacological Characterization, and Bioavailability
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2-Substituted (2SR)-2-Amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 2. Effects of Aromatic Substitution, Pharmacological Characterization, and Bioavailability

Ornstein, Paul L ; Bleisch, Thomas J ; Arnold, M. Brian ; Kennedy, Joseph H ; Wright, Rebecca A ; Johnson, Bryan G ; Tizzano, Joseph P ; Helton, David R ; Kallman, Mary Jeanne ; Schoepp, Darryle D ; Hérin, Marc

Journal of medicinal chemistry, 1998-01, Vol.41 (3), p.358-378 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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10
Structure−Activity Studies of 6-Substituted Decahydroisoquinoline-3-carboxylic Acid AMPA Receptor Antagonists. 2. Effects of Distal Acid Bioisosteric Substitution, Absolute Stereochemical Preferences, and in Vivo Activity
Structure−Activity Studies of 6-Substituted Decahydroisoquinoline-3-carboxylic Acid AMPA Receptor Antagonists. 2. Effects of Distal Acid Bioisosteric Substitution, Absolute Stereochemical Preferences, and in Vivo Activity
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Structure−Activity Studies of 6-Substituted Decahydroisoquinoline-3-carboxylic Acid AMPA Receptor Antagonists. 2. Effects of Distal Acid Bioisosteric Substitution, Absolute Stereochemical Preferences, and in Vivo Activity

Ornstein, Paul L ; Arnold, M. Brian ; Allen, Nancy K ; Bleisch, Thomas ; Borromeo, Peter S ; Lugar, Charles W ; Leander, J. David ; Lodge, David ; Schoepp, Darryle D

Journal of medicinal chemistry, 1996-05, Vol.39 (11), p.2232-2244 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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